Expression of CD markers in JAK2V617F positive myeloproliferative neoplasms: Prognostic significance
Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by the presence of JAK2V617F mutation. Thrombohemorrhagic as well as autoimmune or inflammatory phenomena are common clinical outcomes of these disorders. Recent studies have shown that abnormality in frequency and func...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Oncology Reviews |
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| Online Access: | https://oncologyreviews.org/index.php/or/article/view/373 |
| _version_ | 1797963763252461568 |
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| author | Saeid Shahrabi Ali Ehsanpour Somayyeh Heidary Mohammad Shahjahani Masumeh Maleki Behzad |
| author_facet | Saeid Shahrabi Ali Ehsanpour Somayyeh Heidary Mohammad Shahjahani Masumeh Maleki Behzad |
| author_sort | Saeid Shahrabi |
| collection | DOAJ |
| description | Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by the presence of JAK2V617F mutation. Thrombohemorrhagic as well as autoimmune or inflammatory phenomena are common clinical outcomes of these disorders. Recent studies have shown that abnormality in frequency and function of blood cells manifested by an alteration in CD markers’ expression patterns play a key role in these complications. So, there may be a relationship between CD markers’ expressions and prognosis of JAK2V617F positive MPNs. Therefore, in this review, we have focused on these abnormalities from the perspective of changing expressions of CD markers and assessment of the relationship between these changes with prognosis of JAK2V617F positive MPNs. It can be stated that the abnormal expression of a large number of CD markers can be used as a prognostic biomarker for clinical outcomes including thrombohememorrhagic events, as well as autoimmune and leukemic transformation in JAK2V617F positive MPNs. Considering the possible role of CD markers’ expressions in JAK2V617F MPNs prognosis, further studies are needed to confirm the relationship between the expression of CD markers with prognosis to be able to find an appropriate therapeutic approach via targeting CD markers. |
| first_indexed | 2024-04-11T01:34:26Z |
| format | Article |
| id | doaj.art-25adac0ad0a946aa90fd66c86e16a418 |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T01:34:26Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-25adac0ad0a946aa90fd66c86e16a4182023-01-03T09:04:33ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652018-10-0112210.4081/oncol.2018.373Expression of CD markers in JAK2V617F positive myeloproliferative neoplasms: Prognostic significanceSaeid Shahrabi0Ali Ehsanpour1Somayyeh Heidary2Mohammad Shahjahani3Masumeh Maleki Behzad4Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, SemnanThalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, AhvazThalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, AhvazThalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, AhvazThalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, AhvazMyeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by the presence of JAK2V617F mutation. Thrombohemorrhagic as well as autoimmune or inflammatory phenomena are common clinical outcomes of these disorders. Recent studies have shown that abnormality in frequency and function of blood cells manifested by an alteration in CD markers’ expression patterns play a key role in these complications. So, there may be a relationship between CD markers’ expressions and prognosis of JAK2V617F positive MPNs. Therefore, in this review, we have focused on these abnormalities from the perspective of changing expressions of CD markers and assessment of the relationship between these changes with prognosis of JAK2V617F positive MPNs. It can be stated that the abnormal expression of a large number of CD markers can be used as a prognostic biomarker for clinical outcomes including thrombohememorrhagic events, as well as autoimmune and leukemic transformation in JAK2V617F positive MPNs. Considering the possible role of CD markers’ expressions in JAK2V617F MPNs prognosis, further studies are needed to confirm the relationship between the expression of CD markers with prognosis to be able to find an appropriate therapeutic approach via targeting CD markers.https://oncologyreviews.org/index.php/or/article/view/373JAK2V617FCD markerspolycythemia veraessential thrombocythemiaprimary myelofibrosisprognosis. |
| spellingShingle | Saeid Shahrabi Ali Ehsanpour Somayyeh Heidary Mohammad Shahjahani Masumeh Maleki Behzad Expression of CD markers in JAK2V617F positive myeloproliferative neoplasms: Prognostic significance Oncology Reviews JAK2V617F CD markers polycythemia vera essential thrombocythemia primary myelofibrosis prognosis. |
| title | Expression of CD markers in JAK2V617F positive myeloproliferative neoplasms: Prognostic significance |
| title_full | Expression of CD markers in JAK2V617F positive myeloproliferative neoplasms: Prognostic significance |
| title_fullStr | Expression of CD markers in JAK2V617F positive myeloproliferative neoplasms: Prognostic significance |
| title_full_unstemmed | Expression of CD markers in JAK2V617F positive myeloproliferative neoplasms: Prognostic significance |
| title_short | Expression of CD markers in JAK2V617F positive myeloproliferative neoplasms: Prognostic significance |
| title_sort | expression of cd markers in jak2v617f positive myeloproliferative neoplasms prognostic significance |
| topic | JAK2V617F CD markers polycythemia vera essential thrombocythemia primary myelofibrosis prognosis. |
| url | https://oncologyreviews.org/index.php/or/article/view/373 |
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