A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice
The coordination of movement across the body is a fundamental, yet poorly understood aspect of motor control. Mutant mice with cerebellar circuit defects exhibit characteristic impairments in locomotor coordination; however, the fundamental features of this gait ataxia have not been effectively isol...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2015-10-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/07892 |
| _version_ | 1811227905198391296 |
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| author | Ana S Machado Dana M Darmohray João Fayad Hugo G Marques Megan R Carey |
| author_facet | Ana S Machado Dana M Darmohray João Fayad Hugo G Marques Megan R Carey |
| author_sort | Ana S Machado |
| collection | DOAJ |
| description | The coordination of movement across the body is a fundamental, yet poorly understood aspect of motor control. Mutant mice with cerebellar circuit defects exhibit characteristic impairments in locomotor coordination; however, the fundamental features of this gait ataxia have not been effectively isolated. Here we describe a novel system (LocoMouse) for analyzing limb, head, and tail kinematics of freely walking mice. Analysis of visibly ataxic Purkinje cell degeneration (pcd) mice reveals that while differences in the forward motion of individual paws are fully accounted for by changes in walking speed and body size, more complex 3D trajectories and, especially, inter-limb and whole-body coordination are specifically impaired. Moreover, the coordination deficits in pcd are consistent with a failure to predict and compensate for the consequences of movement across the body. These results isolate specific impairments in whole-body coordination in mice and provide a quantitative framework for understanding cerebellar contributions to coordinated locomotion. |
| first_indexed | 2024-04-12T09:49:37Z |
| format | Article |
| id | doaj.art-25af2af59bbf492a805c87829e01e761 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:49:37Z |
| publishDate | 2015-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-25af2af59bbf492a805c87829e01e7612022-12-22T03:37:52ZengeLife Sciences Publications LtdeLife2050-084X2015-10-01410.7554/eLife.07892A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic miceAna S Machado0Dana M Darmohray1João Fayad2Hugo G Marques3Megan R Carey4https://orcid.org/0000-0002-4499-1657Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Champalimaud Foundation, Lisbon, PortugalChampalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Champalimaud Foundation, Lisbon, PortugalChampalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Champalimaud Foundation, Lisbon, PortugalChampalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Champalimaud Foundation, Lisbon, PortugalChampalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Champalimaud Foundation, Lisbon, PortugalThe coordination of movement across the body is a fundamental, yet poorly understood aspect of motor control. Mutant mice with cerebellar circuit defects exhibit characteristic impairments in locomotor coordination; however, the fundamental features of this gait ataxia have not been effectively isolated. Here we describe a novel system (LocoMouse) for analyzing limb, head, and tail kinematics of freely walking mice. Analysis of visibly ataxic Purkinje cell degeneration (pcd) mice reveals that while differences in the forward motion of individual paws are fully accounted for by changes in walking speed and body size, more complex 3D trajectories and, especially, inter-limb and whole-body coordination are specifically impaired. Moreover, the coordination deficits in pcd are consistent with a failure to predict and compensate for the consequences of movement across the body. These results isolate specific impairments in whole-body coordination in mice and provide a quantitative framework for understanding cerebellar contributions to coordinated locomotion.https://elifesciences.org/articles/07892locomotionataxiacerebellumPurkinje cell |
| spellingShingle | Ana S Machado Dana M Darmohray João Fayad Hugo G Marques Megan R Carey A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice eLife locomotion ataxia cerebellum Purkinje cell |
| title | A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice |
| title_full | A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice |
| title_fullStr | A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice |
| title_full_unstemmed | A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice |
| title_short | A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice |
| title_sort | quantitative framework for whole body coordination reveals specific deficits in freely walking ataxic mice |
| topic | locomotion ataxia cerebellum Purkinje cell |
| url | https://elifesciences.org/articles/07892 |
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