Drug Use Evaluation of Ceftriaxone in Ras-Desta Memorial General Hospital, Ethiopia
Oumer Sada Muhammed, Beshir Bedru Nasir Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Beshir Bedru Nasir Department of Pharmacology and Clinical PharmacySchool of Pharmacy, College of Hea...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Drug, Healthcare and Patient Safety |
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| Online Access: | https://www.dovepress.com/drug-use-evaluation-of-ceftriaxone-in-ras-desta-memorial-general-hospi-peer-reviewed-article-DHPS |
| _version_ | 1819266145833713664 |
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| author | Muhammed OS Nasir BB |
| author_facet | Muhammed OS Nasir BB |
| author_sort | Muhammed OS |
| collection | DOAJ |
| description | Oumer Sada Muhammed, Beshir Bedru Nasir Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Beshir Bedru Nasir Department of Pharmacology and Clinical PharmacySchool of Pharmacy, College of Health Sciences, Addis Ababa University, Churchill Avenue, P.O. Box 1176, Addis Ababa, EthiopiaEmail beshir.bedru@aau.edu.etBackground: Ceftriaxone is one of the most commonly used antibiotics due to its availability, wide spectrum of activity and low toxicity. However, irrational use of ceftriaxone is one of the current issues in most countries, especially developing ones.Objective: The aim of this study was to evaluate ceftriaxone utilization in different wards of Ras-Desta Memorial General Hospital (RDMGH) in Ethiopia.Methods: An institution-based retrospective cross-sectional study was conducted on randomly selected 1,079 patients who were admitted to RDMGH from May 2017 to April 2018. A structured data abstraction format was used to collect data from patients’ medical chart. Micromedex® drug interaction checker was used to identify significant drug–drug interactions, and national and international guidelines were used to evaluate the appropriateness of ceftriaxone use. The data were analyzed by using SPSS version 20.0.Results: Among the 1,079 patients enrolled, ceftriaxone was utilized by 601 (55.7%) patients, and these patients were considered for evaluation of appropriateness and subsequent analysis. Among 601 patients, ceftriaxone was used for therapeutic purpose in 362 (60.2%) patients; of which, 359 (99.2%) were for empiric therapy and the rest 239 (39.8%) were for prophylaxis. In the majority of the patients, the dose of ceftriaxone was 2g/day 472 (78.6%) and for a duration of 2– 7 days 409 (68.1%). Inappropriate use of ceftriaxone was observed among 237 (39.4%) patients with regard to indication, dose/frequency and duration. About half (49.3%) of the deviation from the guidelines was observed from surgical and gynecologic/obstetrics wards. Among the co-prescribed medications with ceftriaxone, ringer lactate, warfarin and heparin were found to have a significant drug–drug interaction.Conclusion: This study revealed that inappropriate use of ceftriaxone was high in RDMGH. This may increase the emergence of resistant pathogens which may lead to treatment failure and increase cost of therapy. Therefore, adherence to current evidence-based guidelines is recommended.Keywords: antimicrobials, ceftriaxone, drug use evaluation; DUE, Ethiopia |
| first_indexed | 2024-12-23T20:56:37Z |
| format | Article |
| id | doaj.art-25af51562cb24ae7b676b81498ca6457 |
| institution | Directory Open Access Journal |
| issn | 1179-1365 |
| language | English |
| last_indexed | 2024-12-23T20:56:37Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug, Healthcare and Patient Safety |
| spelling | doaj.art-25af51562cb24ae7b676b81498ca64572022-12-21T17:31:30ZengDove Medical PressDrug, Healthcare and Patient Safety1179-13652020-09-01Volume 1216116856900Drug Use Evaluation of Ceftriaxone in Ras-Desta Memorial General Hospital, EthiopiaMuhammed OSNasir BBOumer Sada Muhammed, Beshir Bedru Nasir Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Beshir Bedru Nasir Department of Pharmacology and Clinical PharmacySchool of Pharmacy, College of Health Sciences, Addis Ababa University, Churchill Avenue, P.O. Box 1176, Addis Ababa, EthiopiaEmail beshir.bedru@aau.edu.etBackground: Ceftriaxone is one of the most commonly used antibiotics due to its availability, wide spectrum of activity and low toxicity. However, irrational use of ceftriaxone is one of the current issues in most countries, especially developing ones.Objective: The aim of this study was to evaluate ceftriaxone utilization in different wards of Ras-Desta Memorial General Hospital (RDMGH) in Ethiopia.Methods: An institution-based retrospective cross-sectional study was conducted on randomly selected 1,079 patients who were admitted to RDMGH from May 2017 to April 2018. A structured data abstraction format was used to collect data from patients’ medical chart. Micromedex® drug interaction checker was used to identify significant drug–drug interactions, and national and international guidelines were used to evaluate the appropriateness of ceftriaxone use. The data were analyzed by using SPSS version 20.0.Results: Among the 1,079 patients enrolled, ceftriaxone was utilized by 601 (55.7%) patients, and these patients were considered for evaluation of appropriateness and subsequent analysis. Among 601 patients, ceftriaxone was used for therapeutic purpose in 362 (60.2%) patients; of which, 359 (99.2%) were for empiric therapy and the rest 239 (39.8%) were for prophylaxis. In the majority of the patients, the dose of ceftriaxone was 2g/day 472 (78.6%) and for a duration of 2– 7 days 409 (68.1%). Inappropriate use of ceftriaxone was observed among 237 (39.4%) patients with regard to indication, dose/frequency and duration. About half (49.3%) of the deviation from the guidelines was observed from surgical and gynecologic/obstetrics wards. Among the co-prescribed medications with ceftriaxone, ringer lactate, warfarin and heparin were found to have a significant drug–drug interaction.Conclusion: This study revealed that inappropriate use of ceftriaxone was high in RDMGH. This may increase the emergence of resistant pathogens which may lead to treatment failure and increase cost of therapy. Therefore, adherence to current evidence-based guidelines is recommended.Keywords: antimicrobials, ceftriaxone, drug use evaluation; DUE, Ethiopiahttps://www.dovepress.com/drug-use-evaluation-of-ceftriaxone-in-ras-desta-memorial-general-hospi-peer-reviewed-article-DHPSantimicrobialsceftriaxonedrug use evaluationethiopia |
| spellingShingle | Muhammed OS Nasir BB Drug Use Evaluation of Ceftriaxone in Ras-Desta Memorial General Hospital, Ethiopia Drug, Healthcare and Patient Safety antimicrobials ceftriaxone drug use evaluation ethiopia |
| title | Drug Use Evaluation of Ceftriaxone in Ras-Desta Memorial General Hospital, Ethiopia |
| title_full | Drug Use Evaluation of Ceftriaxone in Ras-Desta Memorial General Hospital, Ethiopia |
| title_fullStr | Drug Use Evaluation of Ceftriaxone in Ras-Desta Memorial General Hospital, Ethiopia |
| title_full_unstemmed | Drug Use Evaluation of Ceftriaxone in Ras-Desta Memorial General Hospital, Ethiopia |
| title_short | Drug Use Evaluation of Ceftriaxone in Ras-Desta Memorial General Hospital, Ethiopia |
| title_sort | drug use evaluation of ceftriaxone in ras desta memorial general hospital ethiopia |
| topic | antimicrobials ceftriaxone drug use evaluation ethiopia |
| url | https://www.dovepress.com/drug-use-evaluation-of-ceftriaxone-in-ras-desta-memorial-general-hospi-peer-reviewed-article-DHPS |
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