An international, prospective observational study on traumatic brain injury epidemiology study protocol: GEO-TBI: Incidence [version 1; peer review: 2 approved]
Background: The epidemiology of traumatic brain injury (TBI) is unclear – it is estimated to affect 27–69 million individuals yearly with the bulk of the TBI burden in low-to-middle income countries (LMICs). Research has highlighted significant between-hospital variability in TBI outcomes following...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2023-06-01
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| Series: | NIHR Open Research |
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| Online Access: | https://openresearch.nihr.ac.uk/articles/3-34/v1 |
| _version_ | 1797690255031140352 |
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| author | David Clark Tommi Kalevi Korhonen Sara Venturini Sujit Gnanakumar Thomas Bashford Midhun Mohan Indira Devi Bhagavatula Ronnie Baticulon Rocío Fernández-Méndez Ignatius Esene Deepak Gupta Anthony Figaji Tsegazeab Laeke Tariq Khan David Menon Michael Martin Kee B. Park Wellingson Paiva Andres M. Rubiano Jogi V. Pattisapu Hamisi Shabani Vijaya Sekhar Davi Solla Kachinga Sichizya Manjul Tripathi Abenezer Tirsit Bart Depreitere Carole Turner Laura Lippa Corrado Iaccarino Gail Rosseau Andrew Reisner Rikin Trivedi Franco Servadei Angelos Kolias Vicknes Waran Peter Hutchinson Alexis Joannides |
| author_facet | David Clark Tommi Kalevi Korhonen Sara Venturini Sujit Gnanakumar Thomas Bashford Midhun Mohan Indira Devi Bhagavatula Ronnie Baticulon Rocío Fernández-Méndez Ignatius Esene Deepak Gupta Anthony Figaji Tsegazeab Laeke Tariq Khan David Menon Michael Martin Kee B. Park Wellingson Paiva Andres M. Rubiano Jogi V. Pattisapu Hamisi Shabani Vijaya Sekhar Davi Solla Kachinga Sichizya Manjul Tripathi Abenezer Tirsit Bart Depreitere Carole Turner Laura Lippa Corrado Iaccarino Gail Rosseau Andrew Reisner Rikin Trivedi Franco Servadei Angelos Kolias Vicknes Waran Peter Hutchinson Alexis Joannides |
| author_sort | David Clark |
| collection | DOAJ |
| description | Background: The epidemiology of traumatic brain injury (TBI) is unclear – it is estimated to affect 27–69 million individuals yearly with the bulk of the TBI burden in low-to-middle income countries (LMICs). Research has highlighted significant between-hospital variability in TBI outcomes following emergency surgery, but the overall incidence and epidemiology of TBI remains unclear. To address this need, we established the Global Epidemiology and Outcomes following Traumatic Brain Injury (GEO-TBI) registry, enabling recording of all TBI cases requiring admission irrespective of surgical treatment. Objective: The GEO-TBI: Incidence study aims to describe TBI epidemiology and outcomes according to development indices, and to highlight best practices to facilitate further comparative research. Design: Multi-centre, international, registry-based, prospective cohort study. Subjects: Any unit managing TBI and participating in the GEO-TBI registry will be eligible to join the study. Each unit will select a 90-day study period. All TBI patients meeting the registry inclusion criteria (neurosurgical/ICU admission or neurosurgical operation) during the selected study period will be included in the GEO-TBI: Incidence. Methods: All units will form a study team, that will gain local approval, identify eligible patients and input data. Data will be collected via the secure registry platform and validated after collection. Identifiers may be collected if required for local utility in accordance with the GEO-TBI protocol. Data: Data related to initial presentation, interventions and short-term outcomes will be collected in line with the GEO-TBI core dataset, developed following consensus from an iterative survey and feedback process. Patient demographics, injury details, timing and nature of interventions and post-injury care will be collected alongside associated complications. The primary outcome measures for the study will be the Glasgow Outcome at Discharge Scale (GODS) and 14-day mortality. Secondary outcome measures will be mortality and extended Glasgow Outcome Scale (GOSE) at the most recent follow-up timepoint. |
| first_indexed | 2024-03-12T01:56:55Z |
| format | Article |
| id | doaj.art-25afbba7c0d5422db3762b8f7b702fc8 |
| institution | Directory Open Access Journal |
| issn | 2633-4402 |
| language | English |
| last_indexed | 2024-03-12T01:56:55Z |
| publishDate | 2023-06-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | NIHR Open Research |
| spelling | doaj.art-25afbba7c0d5422db3762b8f7b702fc82023-09-08T00:00:01ZengF1000 Research LtdNIHR Open Research2633-44022023-06-01314508An international, prospective observational study on traumatic brain injury epidemiology study protocol: GEO-TBI: Incidence [version 1; peer review: 2 approved]David Clark0Tommi Kalevi Korhonen1https://orcid.org/0000-0002-5500-9200Sara Venturini2Sujit Gnanakumar3Thomas Bashford4https://orcid.org/0000-0003-0228-9779Midhun Mohan5Indira Devi Bhagavatula6https://orcid.org/0000-0003-3272-2465Ronnie Baticulon7Rocío Fernández-Méndez8Ignatius Esene9Deepak Gupta10Anthony Figaji11Tsegazeab Laeke12Tariq Khan13David Menon14Michael Martin15https://orcid.org/0000-0002-9310-724XKee B. Park16Wellingson Paiva17Andres M. Rubiano18Jogi V. Pattisapu19Hamisi Shabani20https://orcid.org/0000-0002-0966-1062Vijaya Sekhar21Davi Solla22Kachinga Sichizya23Manjul Tripathi24Abenezer Tirsit25Bart Depreitere26Carole Turner27Laura Lippa28https://orcid.org/0000-0001-9920-430XCorrado Iaccarino29Gail Rosseau30Andrew Reisner31https://orcid.org/0000-0001-5303-3752Rikin Trivedi32Franco Servadei33Angelos Kolias34Vicknes Waran35Peter Hutchinson36Alexis Joannides37NIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKNIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKNIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKNIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKDivision of Anaesthesia, Department of Medicine, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UKNIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKDepartment of Neurosurgery, National Institute of Mental Health and Neuro Sciences, NIMHANS, Bengaluru, Karnataka, IndiaDivision of Neurosurgery, Department of Neurosciences, Philippine General Hospital & University of the Philippines Manila, Manila, PhilippinesNIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKDivision of Neurosurgery, Faculty of Health Sciences, The University of Bamenda, Bambili, CameroonDepartment of neurosurgery, All India Institute of Medical Sciences, New Delhi, IndiaDivision of Neurosurgery and Neurosciences Institute, University of Cape Town, Cape Town, South AfricaDivision of Neurosurgery, Department of Surgery, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaDepartment of Neurosurgery, North Western General and Research Hospital, Peshawar, PakistanDivision of Anaesthesia, Department of Medicine, University of Cambridge & Cambridge University Hospitals NHS Foundation Trust, Cambridge, UKOrion MedTech Ltd. CIC, Cambridge, UKGlobal Neurosurgery Initiative-Program in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USADivision of Neurosurgery, Department of Neurology, School of Medicine, University of Sao Paulo, São Paulo, BrazilNeurosciences Institute, El Bosque University, Bogotá, ColombiaUniversity of Central Florida College of Medicine, Orlando, Florida, USADepartment of Neurosurgery, Muhimbili Orthopaedic Institute, Dar es Salaam, TanzaniaDepartment of Neurosurgery, King George Hospital, Visakhapatnam, Andra Pradesh, IndiaDivision of Neurosurgery, Department of Neurology, School of Medicine, University of Sao Paulo, São Paulo, BrazilDepartment of Neurosurgery, University Teaching Hospital, Lusaka, ZambiaDepartment of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, Chandigarh, IndiaDivision of Neurosurgery, Department of Surgery, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaDepartment of Neurosciences, University Hospital Leuven, UZ, Leuven, BelgiumNIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKDepartment of Neurosurgery, Ospedale Niguarda, Milan, ItalySchool of Neurosurgery, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, ItalyBarrow Global, Barrow Neurosurgical Institute, Phoenix, Arizona, USADepartments of Neurosurgery and Pediatrics, Children's Healthcare of Atlanta & Emory University School of Medicine, Atlanta, Georgia, USANIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKDepartment of Neurosurgery, Humanitas Research Hospital-IRCCS & Humanitas University, Rozzano, Milan, ItalyNIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKDivision of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaNIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKNIHR Global Health Research Group on Acquired Brain & Spine Injury, University of Cambridge, Cambridge, UKBackground: The epidemiology of traumatic brain injury (TBI) is unclear – it is estimated to affect 27–69 million individuals yearly with the bulk of the TBI burden in low-to-middle income countries (LMICs). Research has highlighted significant between-hospital variability in TBI outcomes following emergency surgery, but the overall incidence and epidemiology of TBI remains unclear. To address this need, we established the Global Epidemiology and Outcomes following Traumatic Brain Injury (GEO-TBI) registry, enabling recording of all TBI cases requiring admission irrespective of surgical treatment. Objective: The GEO-TBI: Incidence study aims to describe TBI epidemiology and outcomes according to development indices, and to highlight best practices to facilitate further comparative research. Design: Multi-centre, international, registry-based, prospective cohort study. Subjects: Any unit managing TBI and participating in the GEO-TBI registry will be eligible to join the study. Each unit will select a 90-day study period. All TBI patients meeting the registry inclusion criteria (neurosurgical/ICU admission or neurosurgical operation) during the selected study period will be included in the GEO-TBI: Incidence. Methods: All units will form a study team, that will gain local approval, identify eligible patients and input data. Data will be collected via the secure registry platform and validated after collection. Identifiers may be collected if required for local utility in accordance with the GEO-TBI protocol. Data: Data related to initial presentation, interventions and short-term outcomes will be collected in line with the GEO-TBI core dataset, developed following consensus from an iterative survey and feedback process. Patient demographics, injury details, timing and nature of interventions and post-injury care will be collected alongside associated complications. The primary outcome measures for the study will be the Glasgow Outcome at Discharge Scale (GODS) and 14-day mortality. Secondary outcome measures will be mortality and extended Glasgow Outcome Scale (GOSE) at the most recent follow-up timepoint.https://openresearch.nihr.ac.uk/articles/3-34/v1epidemiology global registry traumatic brain injuryeng |
| spellingShingle | David Clark Tommi Kalevi Korhonen Sara Venturini Sujit Gnanakumar Thomas Bashford Midhun Mohan Indira Devi Bhagavatula Ronnie Baticulon Rocío Fernández-Méndez Ignatius Esene Deepak Gupta Anthony Figaji Tsegazeab Laeke Tariq Khan David Menon Michael Martin Kee B. Park Wellingson Paiva Andres M. Rubiano Jogi V. Pattisapu Hamisi Shabani Vijaya Sekhar Davi Solla Kachinga Sichizya Manjul Tripathi Abenezer Tirsit Bart Depreitere Carole Turner Laura Lippa Corrado Iaccarino Gail Rosseau Andrew Reisner Rikin Trivedi Franco Servadei Angelos Kolias Vicknes Waran Peter Hutchinson Alexis Joannides An international, prospective observational study on traumatic brain injury epidemiology study protocol: GEO-TBI: Incidence [version 1; peer review: 2 approved] NIHR Open Research epidemiology global registry traumatic brain injury eng |
| title | An international, prospective observational study on traumatic brain injury epidemiology study protocol: GEO-TBI: Incidence [version 1; peer review: 2 approved] |
| title_full | An international, prospective observational study on traumatic brain injury epidemiology study protocol: GEO-TBI: Incidence [version 1; peer review: 2 approved] |
| title_fullStr | An international, prospective observational study on traumatic brain injury epidemiology study protocol: GEO-TBI: Incidence [version 1; peer review: 2 approved] |
| title_full_unstemmed | An international, prospective observational study on traumatic brain injury epidemiology study protocol: GEO-TBI: Incidence [version 1; peer review: 2 approved] |
| title_short | An international, prospective observational study on traumatic brain injury epidemiology study protocol: GEO-TBI: Incidence [version 1; peer review: 2 approved] |
| title_sort | international prospective observational study on traumatic brain injury epidemiology study protocol geo tbi incidence version 1 peer review 2 approved |
| topic | epidemiology global registry traumatic brain injury eng |
| url | https://openresearch.nihr.ac.uk/articles/3-34/v1 |
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