Friends in need: How chaperonins recognize and remodel proteins that require folding assistance
Chaperonins are biological nanomachines that help newly translated proteins to fold by rescuing them from kinetically trapped misfolded states. Protein folding assistance by the chaperonin machinery is obligatory in vivo for a subset of proteins in the bacterial proteome. Chaperonins are large oligo...
Main Authors: | George Stan, George H. Lorimer, D. Thirumalai |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-11-01
|
Series: | Frontiers in Molecular Biosciences |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.1071168/full |
Similar Items
-
In vivo client proteins of the chaperonin GroEL-GroES provide insight into the role of chaperones in protein evolution
by: Hideki Taguchi, et al.
Published: (2023-02-01) -
A Glimpse Into the Structure and Function of Atypical Type I Chaperonins
by: Mohammed Y. Ansari, et al.
Published: (2018-04-01) -
Conversion of an inactive xylose isomerase into a functional enzyme by co-expression of GroEL-GroES chaperonins in Saccharomyces cerevisiae
by: Beatriz Temer, et al.
Published: (2017-09-01) -
Dynamic complexes in the chaperonin-mediated protein folding cycle
by: Celeste Weiss, et al.
Published: (2016-12-01) -
Toward Developing Chemical Modulators of Hsp60 as Potential Therapeutics
by: Qianli Meng, et al.
Published: (2018-04-01)