Health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in China based on epidemiological data
Background: Health risk assessment based on epidemiological data for perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are evidenced. Whereas information about health-based guidance values (HBGVs) and health risk for Chinese population related to PFOS and PFOA is scarce. Objectives:...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Hygiene and Environmental Health Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773049223000223 |
| _version_ | 1797706837942861824 |
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| author | Yun-Ting Zhang Huihui Bao Lei Zhang Sheng Wen Weihong Tan Mohammed Zeeshan Ming-Kun Sun Chu Chu Zhao-Huan Gui Li-Zi Lin Ru-Qing Liu Xiao-Wen Zeng Yunjiang Yu Guang-Hui Dong |
| author_facet | Yun-Ting Zhang Huihui Bao Lei Zhang Sheng Wen Weihong Tan Mohammed Zeeshan Ming-Kun Sun Chu Chu Zhao-Huan Gui Li-Zi Lin Ru-Qing Liu Xiao-Wen Zeng Yunjiang Yu Guang-Hui Dong |
| author_sort | Yun-Ting Zhang |
| collection | DOAJ |
| description | Background: Health risk assessment based on epidemiological data for perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are evidenced. Whereas information about health-based guidance values (HBGVs) and health risk for Chinese population related to PFOS and PFOA is scarce. Objectives: To provide candidate HBGVs for PFOS and PFOA based on Chinese epidemiological data and assess the health risk related to excessive exposure. Methods: We reviewed scientific literature and collected available original data from epidemiological studies conducted in China. Critical endpoints and data were selected and used in benchmark dose (BMD) analysis to obtain lower confidence limits of BMD (BMDLs) of PFOS and PFOA. Physiologically based pharmacokinetic (PBPK) models were applied to calculate the point of departure (PODs) for PFOS and PFOA, which led to the determination of the HBGVs for the said chemicals. Margin of exposure (MOE) method was used to evaluate the health risk of population based on exposure data among Chinese and HBGVs. Results: Alanine aminotransferase (ALT), total cholesterol (TC) and birth weight (BW) were selected as critical endpoints. Epidemiological data from 4,224 adults, 2,153 paired mother-newborn, 2,518 newborns, 439 pregnant women and 733 children in China were included in this study. BMDLs and PODs for PFOS are varied while BMDLs for PFOA were similar. PODs for PFOS (1.56 ng/kg/day) and PFOA (1.52 ng/kg/day) based on BW using National Birth Cohort Study were selected as HBGVs. Most MOEs for PFOS and PFOA among Chinese population were larger than 1 and smaller than 100, indicating moderate concern. Around 16% MOEs for PFOS were smaller than 1, implying high concern. Conclusion: The HBGVs for PFOS and PFOA were 1.56 ng/kg/day and 1.52 ng/kg/day, respectively. Health risk of Chinese population related to PFOS and PFOA exposure should be concerned and more studies should be conducted to evaluate the risk of the chemicals. |
| first_indexed | 2024-03-12T05:57:13Z |
| format | Article |
| id | doaj.art-25b2744b23fa4bccac819c79e406ef6b |
| institution | Directory Open Access Journal |
| issn | 2773-0492 |
| language | English |
| last_indexed | 2024-03-12T05:57:13Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hygiene and Environmental Health Advances |
| spelling | doaj.art-25b2744b23fa4bccac819c79e406ef6b2023-09-03T04:24:41ZengElsevierHygiene and Environmental Health Advances2773-04922023-09-017100066Health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in China based on epidemiological dataYun-Ting Zhang0Huihui Bao1Lei Zhang2Sheng Wen3Weihong Tan4Mohammed Zeeshan5Ming-Kun Sun6Chu Chu7Zhao-Huan Gui8Li-Zi Lin9Ru-Qing Liu10Xiao-Wen Zeng11Yunjiang Yu12Guang-Hui Dong13Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaNHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit, China National Center for Food Safety Risk Assessment, Beijing 100022, ChinaNHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit, China National Center for Food Safety Risk Assessment, Beijing 100022, ChinaDepartment of Environmental Health, Center for Disease Control and Prevention of Hubei Province, Wuhan 430079, ChinaDepartment of Reproductive Medicine and Genetics Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; Corresponding author at: Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China.State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou, China; Corresponding author at: State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China.Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; Corresponding author at: Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China.Background: Health risk assessment based on epidemiological data for perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are evidenced. Whereas information about health-based guidance values (HBGVs) and health risk for Chinese population related to PFOS and PFOA is scarce. Objectives: To provide candidate HBGVs for PFOS and PFOA based on Chinese epidemiological data and assess the health risk related to excessive exposure. Methods: We reviewed scientific literature and collected available original data from epidemiological studies conducted in China. Critical endpoints and data were selected and used in benchmark dose (BMD) analysis to obtain lower confidence limits of BMD (BMDLs) of PFOS and PFOA. Physiologically based pharmacokinetic (PBPK) models were applied to calculate the point of departure (PODs) for PFOS and PFOA, which led to the determination of the HBGVs for the said chemicals. Margin of exposure (MOE) method was used to evaluate the health risk of population based on exposure data among Chinese and HBGVs. Results: Alanine aminotransferase (ALT), total cholesterol (TC) and birth weight (BW) were selected as critical endpoints. Epidemiological data from 4,224 adults, 2,153 paired mother-newborn, 2,518 newborns, 439 pregnant women and 733 children in China were included in this study. BMDLs and PODs for PFOS are varied while BMDLs for PFOA were similar. PODs for PFOS (1.56 ng/kg/day) and PFOA (1.52 ng/kg/day) based on BW using National Birth Cohort Study were selected as HBGVs. Most MOEs for PFOS and PFOA among Chinese population were larger than 1 and smaller than 100, indicating moderate concern. Around 16% MOEs for PFOS were smaller than 1, implying high concern. Conclusion: The HBGVs for PFOS and PFOA were 1.56 ng/kg/day and 1.52 ng/kg/day, respectively. Health risk of Chinese population related to PFOS and PFOA exposure should be concerned and more studies should be conducted to evaluate the risk of the chemicals.http://www.sciencedirect.com/science/article/pii/S2773049223000223Perfluorooctane sulfonatePerfluorooctanoic acidHealth risk assessmentBenchmark dosePhysiologically based pharmacokinetic model |
| spellingShingle | Yun-Ting Zhang Huihui Bao Lei Zhang Sheng Wen Weihong Tan Mohammed Zeeshan Ming-Kun Sun Chu Chu Zhao-Huan Gui Li-Zi Lin Ru-Qing Liu Xiao-Wen Zeng Yunjiang Yu Guang-Hui Dong Health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in China based on epidemiological data Hygiene and Environmental Health Advances Perfluorooctane sulfonate Perfluorooctanoic acid Health risk assessment Benchmark dose Physiologically based pharmacokinetic model |
| title | Health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in China based on epidemiological data |
| title_full | Health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in China based on epidemiological data |
| title_fullStr | Health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in China based on epidemiological data |
| title_full_unstemmed | Health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in China based on epidemiological data |
| title_short | Health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in China based on epidemiological data |
| title_sort | health risk assessment of perfluorooctane sulfonate and perfluorooctanoic acid exposure in china based on epidemiological data |
| topic | Perfluorooctane sulfonate Perfluorooctanoic acid Health risk assessment Benchmark dose Physiologically based pharmacokinetic model |
| url | http://www.sciencedirect.com/science/article/pii/S2773049223000223 |
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