Salvage Surgery of Local Recurrent Nasopharyngeal Carcinoma
There are 10%-36% of nasopharyngeal carcinoma patients suffering from local and/or regional recurrence after primary treatment. The efficacy of re-irradiation to recurrent NPC (rNPC) has been suboptimal. Moreover, the adjacent sensitive organs had already received a high dose of radiation, thus the...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2020-04-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2020.20.0173.htm |
| _version_ | 1818790526375165952 |
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| author | DING Xi CHEN Mingyuan |
| author_facet | DING Xi CHEN Mingyuan |
| author_sort | DING Xi |
| collection | DOAJ |
| description | There are 10%-36% of nasopharyngeal carcinoma patients suffering from local and/or regional recurrence after primary treatment. The efficacy of re-irradiation to recurrent NPC (rNPC) has been suboptimal. Moreover, the adjacent sensitive organs had already received a high dose of radiation, thus the re-irradiation could result in severe radiation-related complications. Surgery could remove the radiation-resistant lesion directly and avoid complications of re-irradiation, therefore, salvage surgery has been well established and become the first-line treatment for rNPC. Various open surgical approaches had been devised for nasopharyngectomy but presented many surgical complications. In recent decade, the endoscopic nasopharyngectomy (ENPG) had gained popularity for rT1-2 and selected rT3 patients with its minimal invasiveness and the resection range is similar to most open surgeries. Additionally, a new Surgical Staging System established to aid clinicians in choosing the most suitable treatment for rNPC patients. Nowadays, the utilization of extracranial/intracranial vascular bypass and internal carotid artery embolization is widening the indications of salvage surgery, while whether the extended resection exhibits better survival than re-irradiation needs further clinical evidence. |
| first_indexed | 2024-12-18T14:56:51Z |
| format | Article |
| id | doaj.art-25b2d86675b6428d8d62feb59f4786e9 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-18T14:56:51Z |
| publishDate | 2020-04-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-25b2d86675b6428d8d62feb59f4786e92022-12-21T21:04:01ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782020-04-0147423524210.3971/j.issn.1000-8578.2020.20.01738578.2020.20.0173Salvage Surgery of Local Recurrent Nasopharyngeal CarcinomaDING Xi0CHEN Mingyuan1Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou 510060, ChinaDepartment of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou 510060, ChinaThere are 10%-36% of nasopharyngeal carcinoma patients suffering from local and/or regional recurrence after primary treatment. The efficacy of re-irradiation to recurrent NPC (rNPC) has been suboptimal. Moreover, the adjacent sensitive organs had already received a high dose of radiation, thus the re-irradiation could result in severe radiation-related complications. Surgery could remove the radiation-resistant lesion directly and avoid complications of re-irradiation, therefore, salvage surgery has been well established and become the first-line treatment for rNPC. Various open surgical approaches had been devised for nasopharyngectomy but presented many surgical complications. In recent decade, the endoscopic nasopharyngectomy (ENPG) had gained popularity for rT1-2 and selected rT3 patients with its minimal invasiveness and the resection range is similar to most open surgeries. Additionally, a new Surgical Staging System established to aid clinicians in choosing the most suitable treatment for rNPC patients. Nowadays, the utilization of extracranial/intracranial vascular bypass and internal carotid artery embolization is widening the indications of salvage surgery, while whether the extended resection exhibits better survival than re-irradiation needs further clinical evidence.http://html.rhhz.net/ZLFZYJ/html/8578.2020.20.0173.htmrecurrentnasopharyngeal carcinomasalvage surgerynasopharyngectomyendoscopic surgery |
| spellingShingle | DING Xi CHEN Mingyuan Salvage Surgery of Local Recurrent Nasopharyngeal Carcinoma Zhongliu Fangzhi Yanjiu recurrent nasopharyngeal carcinoma salvage surgery nasopharyngectomy endoscopic surgery |
| title | Salvage Surgery of Local Recurrent Nasopharyngeal Carcinoma |
| title_full | Salvage Surgery of Local Recurrent Nasopharyngeal Carcinoma |
| title_fullStr | Salvage Surgery of Local Recurrent Nasopharyngeal Carcinoma |
| title_full_unstemmed | Salvage Surgery of Local Recurrent Nasopharyngeal Carcinoma |
| title_short | Salvage Surgery of Local Recurrent Nasopharyngeal Carcinoma |
| title_sort | salvage surgery of local recurrent nasopharyngeal carcinoma |
| topic | recurrent nasopharyngeal carcinoma salvage surgery nasopharyngectomy endoscopic surgery |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2020.20.0173.htm |
| work_keys_str_mv | AT dingxi salvagesurgeryoflocalrecurrentnasopharyngealcarcinoma AT chenmingyuan salvagesurgeryoflocalrecurrentnasopharyngealcarcinoma |