The prevalence of isolated hepatitis B core antibody and its related risk factors among male injected drug users in Isfahan prisons
Background: The prevalence of isolated hepatitis B core antibody (anti-HBc) varies between 1% and 30% in different populations. Isolated anti-HBc-positive patients who suffer from occult hepatitis B virus (HBV) infection have the potential to transmit HBV infection. So isolated anti-HBc screening is...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Advanced Biomedical Research |
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| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=17;epage=17;aulast=Shirani |
| _version_ | 1811210364136718336 |
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| author | Kiana Shirani Zary Nokhodian Nazila Kassaian Peyman Adibi Alireza Emami Naeini Behrooz Ataei |
| author_facet | Kiana Shirani Zary Nokhodian Nazila Kassaian Peyman Adibi Alireza Emami Naeini Behrooz Ataei |
| author_sort | Kiana Shirani |
| collection | DOAJ |
| description | Background: The prevalence of isolated hepatitis B core antibody (anti-HBc) varies between 1% and 30% in different populations. Isolated anti-HBc-positive patients who suffer from occult hepatitis B virus (HBV) infection have the potential to transmit HBV infection. So isolated anti-HBc screening is a valuable tool to prevent HBV transmission. Considering the importance of isolated anti-HBc screening and high prevalence of HBV among injected drug users (IDU) prisoners, we designed this study to evaluate the isolated anti-HBc positivity among inmates with the history of IDU in our area.
Materials and Methods: We did this cross-sectional study from September 2009 to March 2010 among volunteer male IDU prisoners in Isfahan. Blood samples were taken from all of subjects and tested for HBV markers. Then a questionnaire containing socio-demographic, drug histories and high risk behaviors information was completed for all participants. Data analysis was done utilizing univariate analysis and multiple logistic regressions. A P < 0.05 was considered significant.
Results: Totally 970 male IDU prisoners (mean age 32.6 ± 8.1) were included in our study. The prevalence of isolated HBc Ab was 4.5%. Isolated anti-HBc significantly was related to tooth filling (OR: 2.62, CI: 1.20-7.14) and imprisonment (OR: 3.95, CI: 1.39-11.18 ) . We couldn′t find any relationship between isolated anti-HBc positivity and addiction duration, incarceration frequency, recent incarceration duration or number of injection per month.
Conclusion: For screening high risk groups in parallel with hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb) and other viral markers, maybe it is better to check HBcAb too, because isolated HBcAb-positive patients may have occult hepatitis B infection which could transfer the infection to others. |
| first_indexed | 2024-04-12T04:54:22Z |
| format | Article |
| id | doaj.art-25b366478b2b4a2aa4edbd8110a5efc8 |
| institution | Directory Open Access Journal |
| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-04-12T04:54:22Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-25b366478b2b4a2aa4edbd8110a5efc82022-12-22T03:47:11ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752015-01-0141171710.4103/2277-9175.148675The prevalence of isolated hepatitis B core antibody and its related risk factors among male injected drug users in Isfahan prisonsKiana ShiraniZary NokhodianNazila KassaianPeyman AdibiAlireza Emami NaeiniBehrooz AtaeiBackground: The prevalence of isolated hepatitis B core antibody (anti-HBc) varies between 1% and 30% in different populations. Isolated anti-HBc-positive patients who suffer from occult hepatitis B virus (HBV) infection have the potential to transmit HBV infection. So isolated anti-HBc screening is a valuable tool to prevent HBV transmission. Considering the importance of isolated anti-HBc screening and high prevalence of HBV among injected drug users (IDU) prisoners, we designed this study to evaluate the isolated anti-HBc positivity among inmates with the history of IDU in our area. Materials and Methods: We did this cross-sectional study from September 2009 to March 2010 among volunteer male IDU prisoners in Isfahan. Blood samples were taken from all of subjects and tested for HBV markers. Then a questionnaire containing socio-demographic, drug histories and high risk behaviors information was completed for all participants. Data analysis was done utilizing univariate analysis and multiple logistic regressions. A P < 0.05 was considered significant. Results: Totally 970 male IDU prisoners (mean age 32.6 ± 8.1) were included in our study. The prevalence of isolated HBc Ab was 4.5%. Isolated anti-HBc significantly was related to tooth filling (OR: 2.62, CI: 1.20-7.14) and imprisonment (OR: 3.95, CI: 1.39-11.18 ) . We couldn′t find any relationship between isolated anti-HBc positivity and addiction duration, incarceration frequency, recent incarceration duration or number of injection per month. Conclusion: For screening high risk groups in parallel with hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb) and other viral markers, maybe it is better to check HBcAb too, because isolated HBcAb-positive patients may have occult hepatitis B infection which could transfer the infection to others.http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=17;epage=17;aulast=ShiraniInjected drug usersisolated anti hepatitis B coreprison |
| spellingShingle | Kiana Shirani Zary Nokhodian Nazila Kassaian Peyman Adibi Alireza Emami Naeini Behrooz Ataei The prevalence of isolated hepatitis B core antibody and its related risk factors among male injected drug users in Isfahan prisons Advanced Biomedical Research Injected drug users isolated anti hepatitis B core prison |
| title | The prevalence of isolated hepatitis B core antibody and its related risk factors among male injected drug users in Isfahan prisons |
| title_full | The prevalence of isolated hepatitis B core antibody and its related risk factors among male injected drug users in Isfahan prisons |
| title_fullStr | The prevalence of isolated hepatitis B core antibody and its related risk factors among male injected drug users in Isfahan prisons |
| title_full_unstemmed | The prevalence of isolated hepatitis B core antibody and its related risk factors among male injected drug users in Isfahan prisons |
| title_short | The prevalence of isolated hepatitis B core antibody and its related risk factors among male injected drug users in Isfahan prisons |
| title_sort | prevalence of isolated hepatitis b core antibody and its related risk factors among male injected drug users in isfahan prisons |
| topic | Injected drug users isolated anti hepatitis B core prison |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=17;epage=17;aulast=Shirani |
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