| Summary: | LncRNAs are involved in the occurrence and progressions of multiple cancers. Emerging evidence has shown that <i>PCAT6</i>, a newly discovered carcinogenic lncRNA, is abnormally elevated in various human malignant tumors. Until now, <i>PCAT6</i> has been found to sponge various miRNAs to activate the signaling pathways, which further affects tumor cell proliferation, migration, invasion, cycle, apoptosis, radioresistance, and chemoresistance. Moreover, <i>PCAT6</i> has been shown to exert biological functions beyond ceRNAs. In this review, we summarize the biological characteristics of <i>PCAT6</i> in a variety of human malignancies and describe the biological mechanisms by which <i>PCAT6</i> can facilitate tumor progression. Finally, we discuss its diagnostic and prognostic values and clinical applications in various human malignancies.
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