Prevalence of Human Papillomavirus (HPV) among Females in the General Population of the Split and Dalmatia County and Its Association with Genital Microbiota and Infections: A Prospective Study
We conducted a prospective study with the aim of determining HPV prevalence and type distribution in the general female population of Southern Croatia (SDC), and to detect the presence of other microorganisms in the lower part of the female reproductive system and their possible influence on the fre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/2/443 |
| _version_ | 1797617768605941760 |
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| author | Vanja Kaliterna Petar Kaliterna Lidija Pejkovic Robert Vulic Linda Zanchi Karmen Cerskov |
| author_facet | Vanja Kaliterna Petar Kaliterna Lidija Pejkovic Robert Vulic Linda Zanchi Karmen Cerskov |
| author_sort | Vanja Kaliterna |
| collection | DOAJ |
| description | We conducted a prospective study with the aim of determining HPV prevalence and type distribution in the general female population of Southern Croatia (SDC), and to detect the presence of other microorganisms in the lower part of the female reproductive system and their possible influence on the frequency of HPV infection. Data were collected during routine check-up exams. All participants were examined by a gynecologist, and cervico-vaginal scrapings/swabs were collected, for cytological (Pap smear) and microbiological (for bacterial growth, genital mycoplasmas, chlamydia, and HPV) analysis. Informed consent was obtained from all participants with accompanying questionnaire. A total of 1050 asymptomatic women living in SDC participated in the study during a one-year period, and 107 of them (10.2%) had HR-HPV infection. We found that the presence of some bacteria (<i>Ureaplasma</i>, <i>Chlamydia</i>, and <i>Gardnerella</i>) in the lower part of the female genital system has a positive correlation with the frequency of HPV infection and, consequently, a possible influence on faster progression to cervical dysplasia caused by HPV. We consider that inclusion of screening for sexually transmitted infections as monitoring in women with HPV infection could help to find women at risk of cervical cancer progression. |
| first_indexed | 2024-03-11T08:00:26Z |
| format | Article |
| id | doaj.art-25b583bf3bdb4f56a18567269d1c765e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T08:00:26Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-25b583bf3bdb4f56a18567269d1c765e2023-11-16T23:49:05ZengMDPI AGViruses1999-49152023-02-0115244310.3390/v15020443Prevalence of Human Papillomavirus (HPV) among Females in the General Population of the Split and Dalmatia County and Its Association with Genital Microbiota and Infections: A Prospective StudyVanja Kaliterna0Petar Kaliterna1Lidija Pejkovic2Robert Vulic3Linda Zanchi4Karmen Cerskov5Teaching Institute for Public Health of Split and Dalmatia County, 21000 Split, CroatiaSchool of Medicine, University of Split, 21000 Split, CroatiaGynecological Practice, 21210 Solin, CroatiaGynecological Practice, 21000 Split, CroatiaGynecological Practice, 21212 Kastel Sucurac, CroatiaGynecological Practice, 21212 Kastel Sucurac, CroatiaWe conducted a prospective study with the aim of determining HPV prevalence and type distribution in the general female population of Southern Croatia (SDC), and to detect the presence of other microorganisms in the lower part of the female reproductive system and their possible influence on the frequency of HPV infection. Data were collected during routine check-up exams. All participants were examined by a gynecologist, and cervico-vaginal scrapings/swabs were collected, for cytological (Pap smear) and microbiological (for bacterial growth, genital mycoplasmas, chlamydia, and HPV) analysis. Informed consent was obtained from all participants with accompanying questionnaire. A total of 1050 asymptomatic women living in SDC participated in the study during a one-year period, and 107 of them (10.2%) had HR-HPV infection. We found that the presence of some bacteria (<i>Ureaplasma</i>, <i>Chlamydia</i>, and <i>Gardnerella</i>) in the lower part of the female genital system has a positive correlation with the frequency of HPV infection and, consequently, a possible influence on faster progression to cervical dysplasia caused by HPV. We consider that inclusion of screening for sexually transmitted infections as monitoring in women with HPV infection could help to find women at risk of cervical cancer progression.https://www.mdpi.com/1999-4915/15/2/443HPV prevalenceCroatiacervicovaginal microbiota<i>Ureaplasma</i><i>Chlamydia</i><i>Gardnerela</i> |
| spellingShingle | Vanja Kaliterna Petar Kaliterna Lidija Pejkovic Robert Vulic Linda Zanchi Karmen Cerskov Prevalence of Human Papillomavirus (HPV) among Females in the General Population of the Split and Dalmatia County and Its Association with Genital Microbiota and Infections: A Prospective Study Viruses HPV prevalence Croatia cervicovaginal microbiota <i>Ureaplasma</i> <i>Chlamydia</i> <i>Gardnerela</i> |
| title | Prevalence of Human Papillomavirus (HPV) among Females in the General Population of the Split and Dalmatia County and Its Association with Genital Microbiota and Infections: A Prospective Study |
| title_full | Prevalence of Human Papillomavirus (HPV) among Females in the General Population of the Split and Dalmatia County and Its Association with Genital Microbiota and Infections: A Prospective Study |
| title_fullStr | Prevalence of Human Papillomavirus (HPV) among Females in the General Population of the Split and Dalmatia County and Its Association with Genital Microbiota and Infections: A Prospective Study |
| title_full_unstemmed | Prevalence of Human Papillomavirus (HPV) among Females in the General Population of the Split and Dalmatia County and Its Association with Genital Microbiota and Infections: A Prospective Study |
| title_short | Prevalence of Human Papillomavirus (HPV) among Females in the General Population of the Split and Dalmatia County and Its Association with Genital Microbiota and Infections: A Prospective Study |
| title_sort | prevalence of human papillomavirus hpv among females in the general population of the split and dalmatia county and its association with genital microbiota and infections a prospective study |
| topic | HPV prevalence Croatia cervicovaginal microbiota <i>Ureaplasma</i> <i>Chlamydia</i> <i>Gardnerela</i> |
| url | https://www.mdpi.com/1999-4915/15/2/443 |
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