Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder
ObjectiveStudies on alterations in the regional neural activity in the brain of patients with bipolar disorder (BD) have provided conflicting results because of different medications used and study designs. A low bone mineral density (BMD) is also observed in patients with BD. This study aimed to fu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00825/full |
| _version_ | 1818280779016306688 |
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| author | Xiaoxiao Shan Yan Qiu Pan Pan Ziwei Teng Sujuan Li Hui Tang Hui Xiang Chujun Wu Yuxi Tan Jindong Chen Wenbin Guo Wenbin Guo Bolun Wang Haishan Wu |
| author_facet | Xiaoxiao Shan Yan Qiu Pan Pan Ziwei Teng Sujuan Li Hui Tang Hui Xiang Chujun Wu Yuxi Tan Jindong Chen Wenbin Guo Wenbin Guo Bolun Wang Haishan Wu |
| author_sort | Xiaoxiao Shan |
| collection | DOAJ |
| description | ObjectiveStudies on alterations in the regional neural activity in the brain of patients with bipolar disorder (BD) have provided conflicting results because of different medications used and study designs. A low bone mineral density (BMD) is also observed in patients with BD. This study aimed to further explore regional neural activities in unmedicated patients with BD and their association with BMD.MethodsIn this study, 40 patients with BD and 42 healthy controls were scanned through resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with regional homogeneity (ReHo) and pattern classification. Pearson’s correlation analyses were performed to explore the correlations between abnormal ReHo and BMD.ResultsA significant increase in ReHo values in the left inferior frontal gyrus (IFG)/temporal pole, left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem, and right superior temporal gyrus (STG) and a decrease in ReHo in the occipital gyrus (OG; left middle OG/superior OG/bilateral cuneus) were found in the patients with BD (p < 0.05) compared with those in the healthy controls. No significant correlation was observed between the abnormal ReHo values in any of the brain regions of the patients with BMD.Support vector machine (SVM) analyses revealed that the ReHo values in the right STG for distinguishing patients from healthy controls showed an accuracy of 91.89%, a sensitivity of 75.68%, and a specificity of 83.78%. The ReHo values in the left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem indicated an accuracy of 78.38%, a sensitivity of 75.68%, and a specificity of 81.08%.ConclusionThis study further confirms the abnormal brain activities in extensive regions, and these brain regions are primarily located in the fronto–temporal–occipital circuit and the cerebellum vermis of patients with BD. The regional neural activity in the right STG and the left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem may serve as potential imaging markers to distinguish patients with BD from healthy controls. |
| first_indexed | 2024-12-12T23:54:38Z |
| format | Article |
| id | doaj.art-25b5f865d84f45a3a76afc04d8c815e2 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-12T23:54:38Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-25b5f865d84f45a3a76afc04d8c815e22022-12-22T00:06:36ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-08-011110.3389/fpsyt.2020.00825558103Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar DisorderXiaoxiao Shan0Yan Qiu1Pan Pan2Ziwei Teng3Sujuan Li4Hui Tang5Hui Xiang6Chujun Wu7Yuxi Tan8Jindong Chen9Wenbin Guo10Wenbin Guo11Bolun Wang12Haishan Wu13National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, The Third People’s Hospital of Foshan, Foshan, ChinaDepartment of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, ChinaObjectiveStudies on alterations in the regional neural activity in the brain of patients with bipolar disorder (BD) have provided conflicting results because of different medications used and study designs. A low bone mineral density (BMD) is also observed in patients with BD. This study aimed to further explore regional neural activities in unmedicated patients with BD and their association with BMD.MethodsIn this study, 40 patients with BD and 42 healthy controls were scanned through resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with regional homogeneity (ReHo) and pattern classification. Pearson’s correlation analyses were performed to explore the correlations between abnormal ReHo and BMD.ResultsA significant increase in ReHo values in the left inferior frontal gyrus (IFG)/temporal pole, left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem, and right superior temporal gyrus (STG) and a decrease in ReHo in the occipital gyrus (OG; left middle OG/superior OG/bilateral cuneus) were found in the patients with BD (p < 0.05) compared with those in the healthy controls. No significant correlation was observed between the abnormal ReHo values in any of the brain regions of the patients with BMD.Support vector machine (SVM) analyses revealed that the ReHo values in the right STG for distinguishing patients from healthy controls showed an accuracy of 91.89%, a sensitivity of 75.68%, and a specificity of 83.78%. The ReHo values in the left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem indicated an accuracy of 78.38%, a sensitivity of 75.68%, and a specificity of 81.08%.ConclusionThis study further confirms the abnormal brain activities in extensive regions, and these brain regions are primarily located in the fronto–temporal–occipital circuit and the cerebellum vermis of patients with BD. The regional neural activity in the right STG and the left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem may serve as potential imaging markers to distinguish patients with BD from healthy controls.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00825/fullbipolar disorderregional homogeneitysupport vector regressionmagnetic resonance imagingbone mineral density |
| spellingShingle | Xiaoxiao Shan Yan Qiu Pan Pan Ziwei Teng Sujuan Li Hui Tang Hui Xiang Chujun Wu Yuxi Tan Jindong Chen Wenbin Guo Wenbin Guo Bolun Wang Haishan Wu Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder Frontiers in Psychiatry bipolar disorder regional homogeneity support vector regression magnetic resonance imaging bone mineral density |
| title | Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder |
| title_full | Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder |
| title_fullStr | Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder |
| title_full_unstemmed | Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder |
| title_short | Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder |
| title_sort | disrupted regional homogeneity in drug naive patients with bipolar disorder |
| topic | bipolar disorder regional homogeneity support vector regression magnetic resonance imaging bone mineral density |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00825/full |
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