Patient survival after surgical resection of pelvic bone sarcomas: A nationwide cohort study
Background: Pelvic bone sarcomas are extremely rare malignant tumours. Patients require a multidisciplinary approach to plan the treatment and complex surgical resections and limb-sparing reconstructions associated with complications, revisions, and functional limitations. The presented nationwide s...
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| Format: | Article |
| Language: | English |
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Slovenian Medical Association
2022-12-01
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| Series: | Zdravniški Vestnik |
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| Online Access: | https://vestnik.szd.si/index.php/ZdravVest/article/view/3368 |
| _version_ | 1828083986295947264 |
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| author | Aljaž Merčun David Martinčič Marko Špiler Blaž Mavčič |
| author_facet | Aljaž Merčun David Martinčič Marko Špiler Blaž Mavčič |
| author_sort | Aljaž Merčun |
| collection | DOAJ |
| description | Background: Pelvic bone sarcomas are extremely rare malignant tumours. Patients require a multidisciplinary approach to plan the treatment and complex surgical resections and limb-sparing reconstructions associated with complications, revisions, and functional limitations. The presented nationwide study in the Republic of Slovenia aims to analyse the oncological survival and functional outcomes of patients after primary resection of pelvic bone sarcomas.
Methods: The retrospective observational cohort included 21 consecutive patients who underwent limb-sparing pelvic resection at a specialized orthopaedic oncology centre in the Republic of Slovenia between 2004-2022. Patient survival, complication rates, and functional outcomes were analysed according to to the primary diagnosis.
Results: Wide margins with R0 resection were achieved in 16 (76%) cases. After a median follow-up of 5.7 (0.6-18.1) years, 7 (33%) patients died of oncological disease, 3 (14%) patients were alive with oncological disease, and 11 (53%) patients were alive with no evidence of disease. The estimated Kaplan-Meier survival probability at 2 years, 5 years, and 10 years after pelvic resection was 85%, 73%, and 45%, respectively. The major complication rate was 29%. The mean Musculoskeletal Tumour Society Score was 17.5 (range 2-29).
Conclusions: Patient survival after resection of pelvic bone sarcomas in Slovenia between 2004-2022 is comparable to previously published reports of European and North American countries. Wide resection of tumours with reconstruction provides a relatively good survival rate, although complications are common and functional outcomes are often poor. |
| first_indexed | 2024-04-11T04:18:10Z |
| format | Article |
| id | doaj.art-25ba6bc53dbd448e992b81ffd4c0c9b8 |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-04-11T04:18:10Z |
| publishDate | 2022-12-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-25ba6bc53dbd448e992b81ffd4c0c9b82022-12-31T08:12:37ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242022-12-019111-1247448210.6016/ZdravVestn.33683368Patient survival after surgical resection of pelvic bone sarcomas: A nationwide cohort studyAljaž Merčun0David Martinčič1Marko Špiler2Blaž Mavčič3Department of Orthopaedic Surgery, University Medical Centre Ljubljana, SloveniaDepartment of Orthopaedic Surgery, University Medical Centre Ljubljana; Faculty of Medicine, University of Ljubljana, SloveniaDepartment of Orthopaedic Surgery, University Medical Centre Ljubljana, SloveniaDepartment of Orthopaedic Surgery, University Medical Centre Ljubljana; Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaBackground: Pelvic bone sarcomas are extremely rare malignant tumours. Patients require a multidisciplinary approach to plan the treatment and complex surgical resections and limb-sparing reconstructions associated with complications, revisions, and functional limitations. The presented nationwide study in the Republic of Slovenia aims to analyse the oncological survival and functional outcomes of patients after primary resection of pelvic bone sarcomas. Methods: The retrospective observational cohort included 21 consecutive patients who underwent limb-sparing pelvic resection at a specialized orthopaedic oncology centre in the Republic of Slovenia between 2004-2022. Patient survival, complication rates, and functional outcomes were analysed according to to the primary diagnosis. Results: Wide margins with R0 resection were achieved in 16 (76%) cases. After a median follow-up of 5.7 (0.6-18.1) years, 7 (33%) patients died of oncological disease, 3 (14%) patients were alive with oncological disease, and 11 (53%) patients were alive with no evidence of disease. The estimated Kaplan-Meier survival probability at 2 years, 5 years, and 10 years after pelvic resection was 85%, 73%, and 45%, respectively. The major complication rate was 29%. The mean Musculoskeletal Tumour Society Score was 17.5 (range 2-29). Conclusions: Patient survival after resection of pelvic bone sarcomas in Slovenia between 2004-2022 is comparable to previously published reports of European and North American countries. Wide resection of tumours with reconstruction provides a relatively good survival rate, although complications are common and functional outcomes are often poor.https://vestnik.szd.si/index.php/ZdravVest/article/view/3368bone sarcomapelvic resectionendoprosthesisreconstruction |
| spellingShingle | Aljaž Merčun David Martinčič Marko Špiler Blaž Mavčič Patient survival after surgical resection of pelvic bone sarcomas: A nationwide cohort study Zdravniški Vestnik bone sarcoma pelvic resection endoprosthesis reconstruction |
| title | Patient survival after surgical resection of pelvic bone sarcomas: A nationwide cohort study |
| title_full | Patient survival after surgical resection of pelvic bone sarcomas: A nationwide cohort study |
| title_fullStr | Patient survival after surgical resection of pelvic bone sarcomas: A nationwide cohort study |
| title_full_unstemmed | Patient survival after surgical resection of pelvic bone sarcomas: A nationwide cohort study |
| title_short | Patient survival after surgical resection of pelvic bone sarcomas: A nationwide cohort study |
| title_sort | patient survival after surgical resection of pelvic bone sarcomas a nationwide cohort study |
| topic | bone sarcoma pelvic resection endoprosthesis reconstruction |
| url | https://vestnik.szd.si/index.php/ZdravVest/article/view/3368 |
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