Polyhydroxyalkanoate Production by <i>Caenibius tardaugens</i> from Steroidal Endocrine Disruptors
The α-proteobacterium <i>Caenibius tardaugens</i> can use estrogens and androgens as the sole carbon source. These compounds are steroidal endocrine disruptors that are found contaminating soil and aquatic ecosystems. Here, we show that <i>C. tardaugens</i>, which has been co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/10/4/706 |
| _version_ | 1827599819378524160 |
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| author | Juan Ibero Virginia Rivero-Buceta José Luis García Beatriz Galán |
| author_facet | Juan Ibero Virginia Rivero-Buceta José Luis García Beatriz Galán |
| author_sort | Juan Ibero |
| collection | DOAJ |
| description | The α-proteobacterium <i>Caenibius tardaugens</i> can use estrogens and androgens as the sole carbon source. These compounds are steroidal endocrine disruptors that are found contaminating soil and aquatic ecosystems. Here, we show that <i>C. tardaugens</i>, which has been considered as a valuable biocatalyst for aerobic steroidal hormone decontamination, is also able to produce polyhydroxyalkanoates (PHA), biodegradable and biocompatible polyesters of increasing biotechnological interest as a sustainable alternative to classical oil-derived polymers. Steroid catabolism yields a significant amount of propionyl-CoA that is metabolically directed towards PHA production through condensation into 3-ketovaleryl-CoA, rendering a PHA rich in 3-hydroxyvalerate. To the best of our knowledge, this is the first report where PHAs are produced from steroids as carbon sources. |
| first_indexed | 2024-03-09T04:22:41Z |
| format | Article |
| id | doaj.art-25bc7f69e76c4486b50b5d75e55d0ee1 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T04:22:41Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-25bc7f69e76c4486b50b5d75e55d0ee12023-12-03T13:44:43ZengMDPI AGMicroorganisms2076-26072022-03-0110470610.3390/microorganisms10040706Polyhydroxyalkanoate Production by <i>Caenibius tardaugens</i> from Steroidal Endocrine DisruptorsJuan Ibero0Virginia Rivero-Buceta1José Luis García2Beatriz Galán3Centro de Investigaciones Biológicas Margarita Salas, 28040 Madrid, SpainCentro de Investigaciones Biológicas Margarita Salas, 28040 Madrid, SpainCentro de Investigaciones Biológicas Margarita Salas, 28040 Madrid, SpainCentro de Investigaciones Biológicas Margarita Salas, 28040 Madrid, SpainThe α-proteobacterium <i>Caenibius tardaugens</i> can use estrogens and androgens as the sole carbon source. These compounds are steroidal endocrine disruptors that are found contaminating soil and aquatic ecosystems. Here, we show that <i>C. tardaugens</i>, which has been considered as a valuable biocatalyst for aerobic steroidal hormone decontamination, is also able to produce polyhydroxyalkanoates (PHA), biodegradable and biocompatible polyesters of increasing biotechnological interest as a sustainable alternative to classical oil-derived polymers. Steroid catabolism yields a significant amount of propionyl-CoA that is metabolically directed towards PHA production through condensation into 3-ketovaleryl-CoA, rendering a PHA rich in 3-hydroxyvalerate. To the best of our knowledge, this is the first report where PHAs are produced from steroids as carbon sources.https://www.mdpi.com/2076-2607/10/4/706steroidsestrogenandrogen<i>C. tardaugens</i>polyhydroxyalkanoatespolyhydroxyvalerate |
| spellingShingle | Juan Ibero Virginia Rivero-Buceta José Luis García Beatriz Galán Polyhydroxyalkanoate Production by <i>Caenibius tardaugens</i> from Steroidal Endocrine Disruptors Microorganisms steroids estrogen androgen <i>C. tardaugens</i> polyhydroxyalkanoates polyhydroxyvalerate |
| title | Polyhydroxyalkanoate Production by <i>Caenibius tardaugens</i> from Steroidal Endocrine Disruptors |
| title_full | Polyhydroxyalkanoate Production by <i>Caenibius tardaugens</i> from Steroidal Endocrine Disruptors |
| title_fullStr | Polyhydroxyalkanoate Production by <i>Caenibius tardaugens</i> from Steroidal Endocrine Disruptors |
| title_full_unstemmed | Polyhydroxyalkanoate Production by <i>Caenibius tardaugens</i> from Steroidal Endocrine Disruptors |
| title_short | Polyhydroxyalkanoate Production by <i>Caenibius tardaugens</i> from Steroidal Endocrine Disruptors |
| title_sort | polyhydroxyalkanoate production by i caenibius tardaugens i from steroidal endocrine disruptors |
| topic | steroids estrogen androgen <i>C. tardaugens</i> polyhydroxyalkanoates polyhydroxyvalerate |
| url | https://www.mdpi.com/2076-2607/10/4/706 |
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