Cyclooxygenase-2 (COX-2) as a Target of Anticancer Agents: A Review of Novel Synthesized Scaffolds Having Anticancer and COX-2 Inhibitory Potentialities
Cancer is a serious threat to human beings and is the second-largest cause of death all over the globe. Chemotherapy is one of the most common treatments for cancer; however, drug resistance and severe adverse effects are major problems associated with anticancer therapy. New compounds with multi-ta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/12/1471 |
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| author | Noor ul Amin Mohsin Sana Aslam Matloob Ahmad Muhammad Irfan Sami A. Al-Hussain Magdi E. A. Zaki |
| author_facet | Noor ul Amin Mohsin Sana Aslam Matloob Ahmad Muhammad Irfan Sami A. Al-Hussain Magdi E. A. Zaki |
| author_sort | Noor ul Amin Mohsin |
| collection | DOAJ |
| description | Cancer is a serious threat to human beings and is the second-largest cause of death all over the globe. Chemotherapy is one of the most common treatments for cancer; however, drug resistance and severe adverse effects are major problems associated with anticancer therapy. New compounds with multi-target inhibitory properties are targeted to surmount these challenges. Cyclooxygenase-2 (COX-2) is overexpressed in cancers of the pancreas, breast, colorectal, stomach, and lung carcinoma. Therefore, COX-2 is considered a significant target for the synthesis of new anticancer agents. This review discusses the biological activity of recently prepared dual anticancer and COX-2 inhibitory agents. The most important intermolecular interactions with the COX-2 enzyme have also been presented. Analysis of these agents in the active area of the COX-2 enzyme could guide the introduction of new lead compounds with extreme selectivity and minor side effects. |
| first_indexed | 2024-03-09T15:59:05Z |
| format | Article |
| id | doaj.art-25bce8b65f8e44bd82dd6f2c7741a1e3 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T15:59:05Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-25bce8b65f8e44bd82dd6f2c7741a1e32023-11-24T17:15:43ZengMDPI AGPharmaceuticals1424-82472022-11-011512147110.3390/ph15121471Cyclooxygenase-2 (COX-2) as a Target of Anticancer Agents: A Review of Novel Synthesized Scaffolds Having Anticancer and COX-2 Inhibitory PotentialitiesNoor ul Amin Mohsin0Sana Aslam1Matloob Ahmad2Muhammad Irfan3Sami A. Al-Hussain4Magdi E. A. Zaki5Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Chemistry, Government College Women University, Faisalabad 38000, PakistanDepartment of Chemistry, Government College University, Faisalabad 38000, PakistanDepartment of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaCancer is a serious threat to human beings and is the second-largest cause of death all over the globe. Chemotherapy is one of the most common treatments for cancer; however, drug resistance and severe adverse effects are major problems associated with anticancer therapy. New compounds with multi-target inhibitory properties are targeted to surmount these challenges. Cyclooxygenase-2 (COX-2) is overexpressed in cancers of the pancreas, breast, colorectal, stomach, and lung carcinoma. Therefore, COX-2 is considered a significant target for the synthesis of new anticancer agents. This review discusses the biological activity of recently prepared dual anticancer and COX-2 inhibitory agents. The most important intermolecular interactions with the COX-2 enzyme have also been presented. Analysis of these agents in the active area of the COX-2 enzyme could guide the introduction of new lead compounds with extreme selectivity and minor side effects.https://www.mdpi.com/1424-8247/15/12/1471drug designhybrid moleculescancer cell linesmolecular dockingCOX-2 |
| spellingShingle | Noor ul Amin Mohsin Sana Aslam Matloob Ahmad Muhammad Irfan Sami A. Al-Hussain Magdi E. A. Zaki Cyclooxygenase-2 (COX-2) as a Target of Anticancer Agents: A Review of Novel Synthesized Scaffolds Having Anticancer and COX-2 Inhibitory Potentialities Pharmaceuticals drug design hybrid molecules cancer cell lines molecular docking COX-2 |
| title | Cyclooxygenase-2 (COX-2) as a Target of Anticancer Agents: A Review of Novel Synthesized Scaffolds Having Anticancer and COX-2 Inhibitory Potentialities |
| title_full | Cyclooxygenase-2 (COX-2) as a Target of Anticancer Agents: A Review of Novel Synthesized Scaffolds Having Anticancer and COX-2 Inhibitory Potentialities |
| title_fullStr | Cyclooxygenase-2 (COX-2) as a Target of Anticancer Agents: A Review of Novel Synthesized Scaffolds Having Anticancer and COX-2 Inhibitory Potentialities |
| title_full_unstemmed | Cyclooxygenase-2 (COX-2) as a Target of Anticancer Agents: A Review of Novel Synthesized Scaffolds Having Anticancer and COX-2 Inhibitory Potentialities |
| title_short | Cyclooxygenase-2 (COX-2) as a Target of Anticancer Agents: A Review of Novel Synthesized Scaffolds Having Anticancer and COX-2 Inhibitory Potentialities |
| title_sort | cyclooxygenase 2 cox 2 as a target of anticancer agents a review of novel synthesized scaffolds having anticancer and cox 2 inhibitory potentialities |
| topic | drug design hybrid molecules cancer cell lines molecular docking COX-2 |
| url | https://www.mdpi.com/1424-8247/15/12/1471 |
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