Reactive oxygen species and nitric oxide imbalances lead to in vivo and in vitro arrhythmogenic phenotype in acute phase of experimental Chagas disease.

Reactive oxygen species and nitric oxide imbalances lead to in vivo and in vitro arrhythmogenic phenotype in acute phase of experimental Chagas disease.

Chagas Disease (CD) is one of the leading causes of heart failure and sudden death in Latin America. Treatments with antioxidants have provided promising alternatives to ameliorate CD. However, the specific roles of major reactive oxygen species (ROS) sources, including NADPH-oxidase 2 (NOX2), mitoc...

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Bibliographic Details
Main Authors:	Artur Santos-Miranda, Julliane Vasconcelos Joviano-Santos, Grazielle Alves Ribeiro, Ana Flávia M Botelho, Peter Rocha, Leda Quercia Vieira, Jader Santos Cruz, Danilo Roman-Campos
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2020-03-01
Series:	PLoS Pathogens
Online Access:	https://doi.org/10.1371/journal.ppat.1008379

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