Nano‐liposomal encapsulation of Artemisia aucheri phenolics as a potential phytobiotic against Campylobacter jejuni infection in mice
Abstract Background Artemisia aucheri contains antibacterial phenolic compounds. The current work was implemented to evaluate the effectiveness of a nanoliposome‐encapsulated phenolic‐rich fraction (PRF‐NLs), as a dietary phytobiotic derived from Artemisia aucheri's areal parts, on the inhibiti...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
|
| Series: | Food Science & Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fsn3.2921 |
| _version_ | 1797996128419971072 |
|---|---|
| author | Asmae Mehdizadeh Ehsan Karimi Ehsan Oskoueian |
| author_facet | Asmae Mehdizadeh Ehsan Karimi Ehsan Oskoueian |
| author_sort | Asmae Mehdizadeh |
| collection | DOAJ |
| description | Abstract Background Artemisia aucheri contains antibacterial phenolic compounds. The current work was implemented to evaluate the effectiveness of a nanoliposome‐encapsulated phenolic‐rich fraction (PRF‐NLs), as a dietary phytobiotic derived from Artemisia aucheri's areal parts, on the inhibition of enteropathogenic Campylobacter jejuni (C. jejuni) infection in mice. Methods The phenolic‐rich fraction was loaded into the nanoliposome structure to obtain a nanometer‐scale size liposome with homogenous dispersion. Next, 40 white male balb/c mice were assigned to 4 treatment groups. The PRF‐NLs antibacterial potential was evaluated by evaluating the blood parameters, liver lipid peroxidation, and gene expression profiling in the mice challenged by C. jejuni infection. Results Mice infected by C. jejuni showed impairment in food intake, weight gain, liver function, ileum morphometric features, and ileum tissue inflammation. The diet of fortified food with the nonencapsulated and nanoliposome‐encapsulated phenolic compounds was found to improve these parameters at 10 mg TPC/kg BW/day concentration. Our data indicated that the nanoliposome‐encapsulated PRF was more effective in promoting the health parameters in mice as compared to nonencapsulated PRF. Conclusion It could be concluded that the liposomal encapsulation can promote the solubility, availability, and effectiveness of Artemisia aucheri phenolic compounds playing a key role as phytobiotic in mice intervened by enteropathogenic C. jejuni. |
| first_indexed | 2024-04-11T10:12:37Z |
| format | Article |
| id | doaj.art-25c1a5d115b647d0b63f6b9a3ab0c070 |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-04-11T10:12:37Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-25c1a5d115b647d0b63f6b9a3ab0c0702022-12-22T04:30:04ZengWileyFood Science & Nutrition2048-71772022-10-0110103314332210.1002/fsn3.2921Nano‐liposomal encapsulation of Artemisia aucheri phenolics as a potential phytobiotic against Campylobacter jejuni infection in miceAsmae Mehdizadeh0Ehsan Karimi1Ehsan Oskoueian2Department of Biology Mashhad Branch Islamic Azad University Mashhad IranDepartment of Biology Mashhad Branch Islamic Azad University Mashhad IranDepartment of Research and Development Arka Industrial Cluster Mashhad IranAbstract Background Artemisia aucheri contains antibacterial phenolic compounds. The current work was implemented to evaluate the effectiveness of a nanoliposome‐encapsulated phenolic‐rich fraction (PRF‐NLs), as a dietary phytobiotic derived from Artemisia aucheri's areal parts, on the inhibition of enteropathogenic Campylobacter jejuni (C. jejuni) infection in mice. Methods The phenolic‐rich fraction was loaded into the nanoliposome structure to obtain a nanometer‐scale size liposome with homogenous dispersion. Next, 40 white male balb/c mice were assigned to 4 treatment groups. The PRF‐NLs antibacterial potential was evaluated by evaluating the blood parameters, liver lipid peroxidation, and gene expression profiling in the mice challenged by C. jejuni infection. Results Mice infected by C. jejuni showed impairment in food intake, weight gain, liver function, ileum morphometric features, and ileum tissue inflammation. The diet of fortified food with the nonencapsulated and nanoliposome‐encapsulated phenolic compounds was found to improve these parameters at 10 mg TPC/kg BW/day concentration. Our data indicated that the nanoliposome‐encapsulated PRF was more effective in promoting the health parameters in mice as compared to nonencapsulated PRF. Conclusion It could be concluded that the liposomal encapsulation can promote the solubility, availability, and effectiveness of Artemisia aucheri phenolic compounds playing a key role as phytobiotic in mice intervened by enteropathogenic C. jejuni.https://doi.org/10.1002/fsn3.2921antibiotic alternativesdrug deliverynanoliposomenatural productsphytogenic |
| spellingShingle | Asmae Mehdizadeh Ehsan Karimi Ehsan Oskoueian Nano‐liposomal encapsulation of Artemisia aucheri phenolics as a potential phytobiotic against Campylobacter jejuni infection in mice Food Science & Nutrition antibiotic alternatives drug delivery nanoliposome natural products phytogenic |
| title | Nano‐liposomal encapsulation of Artemisia aucheri phenolics as a potential phytobiotic against Campylobacter jejuni infection in mice |
| title_full | Nano‐liposomal encapsulation of Artemisia aucheri phenolics as a potential phytobiotic against Campylobacter jejuni infection in mice |
| title_fullStr | Nano‐liposomal encapsulation of Artemisia aucheri phenolics as a potential phytobiotic against Campylobacter jejuni infection in mice |
| title_full_unstemmed | Nano‐liposomal encapsulation of Artemisia aucheri phenolics as a potential phytobiotic against Campylobacter jejuni infection in mice |
| title_short | Nano‐liposomal encapsulation of Artemisia aucheri phenolics as a potential phytobiotic against Campylobacter jejuni infection in mice |
| title_sort | nano liposomal encapsulation of artemisia aucheri phenolics as a potential phytobiotic against campylobacter jejuni infection in mice |
| topic | antibiotic alternatives drug delivery nanoliposome natural products phytogenic |
| url | https://doi.org/10.1002/fsn3.2921 |
| work_keys_str_mv | AT asmaemehdizadeh nanoliposomalencapsulationofartemisiaaucheriphenolicsasapotentialphytobioticagainstcampylobacterjejuniinfectioninmice AT ehsankarimi nanoliposomalencapsulationofartemisiaaucheriphenolicsasapotentialphytobioticagainstcampylobacterjejuniinfectioninmice AT ehsanoskoueian nanoliposomalencapsulationofartemisiaaucheriphenolicsasapotentialphytobioticagainstcampylobacterjejuniinfectioninmice |