Dextran-Cholesterol Carrier Encapsulated Efficient Photosensitizer for the Photodynamic Killing of Cancer Cells
Selective photodynamic therapy (PDT) for cancer cells is more efficient and much safer. Most selective PDTs are realized by antigene-biomarker or peptide-biomarker interactions. Here, we modified dextran with hydrophobic cholesterol as a photosensitizer carrier to selectively target cancer cells, in...
| Main Authors: | , , , , , , |
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MDPI AG
2023-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/11/4404 |
| _version_ | 1827739339252039680 |
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| author | Biru Wu Zhuoheng Gan Shengchang Tao Qiang Wang Yuchen Song Hua Zhong Fang Hu |
| author_facet | Biru Wu Zhuoheng Gan Shengchang Tao Qiang Wang Yuchen Song Hua Zhong Fang Hu |
| author_sort | Biru Wu |
| collection | DOAJ |
| description | Selective photodynamic therapy (PDT) for cancer cells is more efficient and much safer. Most selective PDTs are realized by antigene-biomarker or peptide-biomarker interactions. Here, we modified dextran with hydrophobic cholesterol as a photosensitizer carrier to selectively target cancer cells, including colon cancer cells, and fulfilled selective PDT. The photosensitizer was designed with regular Aggregation-Induced Emission (AIE) units, including triphenylamine and 2-(3-cyano-4,5,5-trimethylfuran-2-ylidene)propanedinitrile. The AIE units can help to decrease the quenching effect in the aggregate state. The efficiency of the photosensitizer is further improved via the heavy atom effect after bromination modification. We found that the obtained photosensitizer nanoparticles could selectively target and ablate cancer cells after encapsulation into the dextran-cholesterol carrier. This study indicates that the polysaccharide-based carrier may have potential for cancer-targeting therapy beyond expectations. |
| first_indexed | 2024-03-11T03:01:22Z |
| format | Article |
| id | doaj.art-25c2c7fd7ecd4f8ba16150a621314b71 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T03:01:22Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-25c2c7fd7ecd4f8ba16150a621314b712023-11-18T08:16:07ZengMDPI AGMolecules1420-30492023-05-012811440410.3390/molecules28114404Dextran-Cholesterol Carrier Encapsulated Efficient Photosensitizer for the Photodynamic Killing of Cancer CellsBiru Wu0Zhuoheng Gan1Shengchang Tao2Qiang Wang3Yuchen Song4Hua Zhong5Fang Hu6Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, ChinaBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, ChinaDepartment of Pharmacy, Affiliated Dongguan Hospital, Southern Medical University, Dongguan 523059, ChinaBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, ChinaBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, ChinaDepartment of Orthopaedics, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510900, ChinaBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, ChinaSelective photodynamic therapy (PDT) for cancer cells is more efficient and much safer. Most selective PDTs are realized by antigene-biomarker or peptide-biomarker interactions. Here, we modified dextran with hydrophobic cholesterol as a photosensitizer carrier to selectively target cancer cells, including colon cancer cells, and fulfilled selective PDT. The photosensitizer was designed with regular Aggregation-Induced Emission (AIE) units, including triphenylamine and 2-(3-cyano-4,5,5-trimethylfuran-2-ylidene)propanedinitrile. The AIE units can help to decrease the quenching effect in the aggregate state. The efficiency of the photosensitizer is further improved via the heavy atom effect after bromination modification. We found that the obtained photosensitizer nanoparticles could selectively target and ablate cancer cells after encapsulation into the dextran-cholesterol carrier. This study indicates that the polysaccharide-based carrier may have potential for cancer-targeting therapy beyond expectations.https://www.mdpi.com/1420-3049/28/11/4404PDTdextranheavy atom |
| spellingShingle | Biru Wu Zhuoheng Gan Shengchang Tao Qiang Wang Yuchen Song Hua Zhong Fang Hu Dextran-Cholesterol Carrier Encapsulated Efficient Photosensitizer for the Photodynamic Killing of Cancer Cells Molecules PDT dextran heavy atom |
| title | Dextran-Cholesterol Carrier Encapsulated Efficient Photosensitizer for the Photodynamic Killing of Cancer Cells |
| title_full | Dextran-Cholesterol Carrier Encapsulated Efficient Photosensitizer for the Photodynamic Killing of Cancer Cells |
| title_fullStr | Dextran-Cholesterol Carrier Encapsulated Efficient Photosensitizer for the Photodynamic Killing of Cancer Cells |
| title_full_unstemmed | Dextran-Cholesterol Carrier Encapsulated Efficient Photosensitizer for the Photodynamic Killing of Cancer Cells |
| title_short | Dextran-Cholesterol Carrier Encapsulated Efficient Photosensitizer for the Photodynamic Killing of Cancer Cells |
| title_sort | dextran cholesterol carrier encapsulated efficient photosensitizer for the photodynamic killing of cancer cells |
| topic | PDT dextran heavy atom |
| url | https://www.mdpi.com/1420-3049/28/11/4404 |
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