Are High Frequency Oscillations in Scalp EEG Related to Age?
BackgroundHigh-frequency oscillations (HFOs) have received much attention in recent years, particularly in the clinical context. In addition to their application as a marker for pathological changes in patients with epilepsy, HFOs have also been brought into context with several physiological mechan...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.722657/full |
| _version_ | 1818333506161344512 |
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| author | Philipp Franz Windhager Adrian V. Marcu Eugen Trinka Eugen Trinka Arne Bathke Yvonne Höller |
| author_facet | Philipp Franz Windhager Adrian V. Marcu Eugen Trinka Eugen Trinka Arne Bathke Yvonne Höller |
| author_sort | Philipp Franz Windhager |
| collection | DOAJ |
| description | BackgroundHigh-frequency oscillations (HFOs) have received much attention in recent years, particularly in the clinical context. In addition to their application as a marker for pathological changes in patients with epilepsy, HFOs have also been brought into context with several physiological mechanisms. Furthermore, recent studies reported a relation between an increase of HFO rate and age in invasive EEG recordings. The present study aimed to investigate whether this relation can be replicated in scalp-EEG.MethodsWe recorded high-density EEG from 11 epilepsy patients at rest as well as during motor performance. Manual detection of HFOs was performed by two independent raters following a standardized protocol. Patients were grouped by age into younger (<25 years) and older (>50 years) participants.ResultsNo significant difference of HFO-rates was found between groups [U = 10.5, p = 0.429, r = 0.3].ConclusionsLack of replicability of the age effect of HFOs may be due to the local propagation patterns of age-related HFOs occurring in deep structures. However, limitations such as small sample size, decreased signal-to-noise ratio as compared to invasive recordings, as well as HFO-mimicking artifacts must be considered. |
| first_indexed | 2024-12-13T13:52:43Z |
| format | Article |
| id | doaj.art-25c36627eabe4bf885d963dcba2622eb |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-13T13:52:43Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-25c36627eabe4bf885d963dcba2622eb2022-12-21T23:43:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-01-011210.3389/fneur.2021.722657722657Are High Frequency Oscillations in Scalp EEG Related to Age?Philipp Franz Windhager0Adrian V. Marcu1Eugen Trinka2Eugen Trinka3Arne Bathke4Yvonne Höller5Department of Neurology, Christian-Doppler Medical Centre and Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, AustriaDepartment of Neurology, Christian-Doppler Medical Centre and Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, AustriaDepartment of Neurology, Christian-Doppler Medical Centre and Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, AustriaNeuroscience Institute, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, AustriaDepartment of Mathematics, Paris Lodron University Salzburg, Salzburg, AustriaFaculty of Psychology, University of Akureyri, Akureyri, IcelandBackgroundHigh-frequency oscillations (HFOs) have received much attention in recent years, particularly in the clinical context. In addition to their application as a marker for pathological changes in patients with epilepsy, HFOs have also been brought into context with several physiological mechanisms. Furthermore, recent studies reported a relation between an increase of HFO rate and age in invasive EEG recordings. The present study aimed to investigate whether this relation can be replicated in scalp-EEG.MethodsWe recorded high-density EEG from 11 epilepsy patients at rest as well as during motor performance. Manual detection of HFOs was performed by two independent raters following a standardized protocol. Patients were grouped by age into younger (<25 years) and older (>50 years) participants.ResultsNo significant difference of HFO-rates was found between groups [U = 10.5, p = 0.429, r = 0.3].ConclusionsLack of replicability of the age effect of HFOs may be due to the local propagation patterns of age-related HFOs occurring in deep structures. However, limitations such as small sample size, decreased signal-to-noise ratio as compared to invasive recordings, as well as HFO-mimicking artifacts must be considered.https://www.frontiersin.org/articles/10.3389/fneur.2021.722657/fullhigh frequency oscillationelectroencephalogramscalp-EEGHD-EEGepilepsy |
| spellingShingle | Philipp Franz Windhager Adrian V. Marcu Eugen Trinka Eugen Trinka Arne Bathke Yvonne Höller Are High Frequency Oscillations in Scalp EEG Related to Age? Frontiers in Neurology high frequency oscillation electroencephalogram scalp-EEG HD-EEG epilepsy |
| title | Are High Frequency Oscillations in Scalp EEG Related to Age? |
| title_full | Are High Frequency Oscillations in Scalp EEG Related to Age? |
| title_fullStr | Are High Frequency Oscillations in Scalp EEG Related to Age? |
| title_full_unstemmed | Are High Frequency Oscillations in Scalp EEG Related to Age? |
| title_short | Are High Frequency Oscillations in Scalp EEG Related to Age? |
| title_sort | are high frequency oscillations in scalp eeg related to age |
| topic | high frequency oscillation electroencephalogram scalp-EEG HD-EEG epilepsy |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.722657/full |
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