Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans
Here, Khurana et al. report the results of a phase 4 clinical trial with three FDA approved influenza vaccines and show that repeat influenza vaccination results in reduced antibody affinity maturation to hemagglutinin domain 1 irrespective of vaccine platform.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11296-5 |
| _version_ | 1818992678560333824 |
|---|---|
| author | Surender Khurana Megan Hahn Elizabeth M. Coyle Lisa R. King Tsai-Lien Lin John Treanor Andrea Sant Hana Golding |
| author_facet | Surender Khurana Megan Hahn Elizabeth M. Coyle Lisa R. King Tsai-Lien Lin John Treanor Andrea Sant Hana Golding |
| author_sort | Surender Khurana |
| collection | DOAJ |
| description | Here, Khurana et al. report the results of a phase 4 clinical trial with three FDA approved influenza vaccines and show that repeat influenza vaccination results in reduced antibody affinity maturation to hemagglutinin domain 1 irrespective of vaccine platform. |
| first_indexed | 2024-12-20T20:29:59Z |
| format | Article |
| id | doaj.art-25c5be5b8b3340e9bfab6fabc559795c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:29:59Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-25c5be5b8b3340e9bfab6fabc559795c2022-12-21T19:27:23ZengNature PortfolioNature Communications2041-17232019-07-0110111510.1038/s41467-019-11296-5Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humansSurender Khurana0Megan Hahn1Elizabeth M. Coyle2Lisa R. King3Tsai-Lien Lin4John Treanor5Andrea Sant6Hana Golding7Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDADivision of Biostatistics, Center for Biologics Evaluation and Research (CBER), FDAUniversity of Rochester Medical CenterUniversity of Rochester Medical CenterDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDAHere, Khurana et al. report the results of a phase 4 clinical trial with three FDA approved influenza vaccines and show that repeat influenza vaccination results in reduced antibody affinity maturation to hemagglutinin domain 1 irrespective of vaccine platform.https://doi.org/10.1038/s41467-019-11296-5 |
| spellingShingle | Surender Khurana Megan Hahn Elizabeth M. Coyle Lisa R. King Tsai-Lien Lin John Treanor Andrea Sant Hana Golding Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans Nature Communications |
| title | Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| title_full | Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| title_fullStr | Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| title_full_unstemmed | Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| title_short | Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| title_sort | repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans |
| url | https://doi.org/10.1038/s41467-019-11296-5 |
| work_keys_str_mv | AT surenderkhurana repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT meganhahn repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT elizabethmcoyle repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT lisarking repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT tsailienlin repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT johntreanor repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT andreasant repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans AT hanagolding repeatvaccinationreducesantibodyaffinitymaturationacrossdifferentinfluenzavaccineplatformsinhumans |