CARdioimaging in Lung Cancer PatiEnts Undergoing Radical RadioTherapy: CARE-RT Trial
Background: Non-small-cell lung cancer (NSCLC) is a common, steady growing lung tumour that is often discovered when a surgical approach is forbidden. For locally advanced inoperable NSCLC, the clinical approach consists of a combination of chemotherapy and radiotherapy, eventually followed by adjuv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/10/1717 |
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| author | Valerio Nardone Maria Paola Belfiore Marco De Chiara Giuseppina De Marco Vittorio Patanè Giovanni Balestrucci Mauro Buono Maria Salvarezza Gaetano Di Guida Domenico D’Angiolella Roberta Grassi Ida D’Onofrio Giovanni Cimmino Carminia Maria Della Corte Antonio Gambardella Floriana Morgillo Fortunato Ciardiello Alfonso Reginelli Salvatore Cappabianca |
| author_facet | Valerio Nardone Maria Paola Belfiore Marco De Chiara Giuseppina De Marco Vittorio Patanè Giovanni Balestrucci Mauro Buono Maria Salvarezza Gaetano Di Guida Domenico D’Angiolella Roberta Grassi Ida D’Onofrio Giovanni Cimmino Carminia Maria Della Corte Antonio Gambardella Floriana Morgillo Fortunato Ciardiello Alfonso Reginelli Salvatore Cappabianca |
| author_sort | Valerio Nardone |
| collection | DOAJ |
| description | Background: Non-small-cell lung cancer (NSCLC) is a common, steady growing lung tumour that is often discovered when a surgical approach is forbidden. For locally advanced inoperable NSCLC, the clinical approach consists of a combination of chemotherapy and radiotherapy, eventually followed by adjuvant immunotherapy, a treatment that is useful but may cause several mild and severe adverse effect. Chest radiotherapy, specifically, may affect the heart and coronary artery, impairing heart function and causing pathologic changes in myocardial tissues. The aim of this study is to evaluate the damage coming from these therapies with the aid of cardiac imaging. Methods: This is a single-centre, prospective clinical trial. Patients with NSCLC who are enrolled will undergo computed tomography (CT) and magnetic resonance imaging (MRI) before chemotherapy 3 months, 6 months, and 9–12 months after the treatment. We expect to enrol 30 patients in 2 years. Conclusions: Our clinical trial will be an opportunity not only to highlight the timing and the radiation dose needed for pathological cardiac tissue changes to happen but will also provide useful data to set new follow-up schedules and strategies, keeping in mind that, more often than not, patients affected by NSCLC may present other heart- and lung-related pathological conditions. |
| first_indexed | 2024-03-11T03:48:25Z |
| format | Article |
| id | doaj.art-25c5c699e2a4499bafe222fac40a03bb |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T03:48:25Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-25c5c699e2a4499bafe222fac40a03bb2023-11-18T01:04:03ZengMDPI AGDiagnostics2075-44182023-05-011310171710.3390/diagnostics13101717CARdioimaging in Lung Cancer PatiEnts Undergoing Radical RadioTherapy: CARE-RT TrialValerio Nardone0Maria Paola Belfiore1Marco De Chiara2Giuseppina De Marco3Vittorio Patanè4Giovanni Balestrucci5Mauro Buono6Maria Salvarezza7Gaetano Di Guida8Domenico D’Angiolella9Roberta Grassi10Ida D’Onofrio11Giovanni Cimmino12Carminia Maria Della Corte13Antonio Gambardella14Floriana Morgillo15Fortunato Ciardiello16Alfonso Reginelli17Salvatore Cappabianca18Department of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Translational Medical Science, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyBackground: Non-small-cell lung cancer (NSCLC) is a common, steady growing lung tumour that is often discovered when a surgical approach is forbidden. For locally advanced inoperable NSCLC, the clinical approach consists of a combination of chemotherapy and radiotherapy, eventually followed by adjuvant immunotherapy, a treatment that is useful but may cause several mild and severe adverse effect. Chest radiotherapy, specifically, may affect the heart and coronary artery, impairing heart function and causing pathologic changes in myocardial tissues. The aim of this study is to evaluate the damage coming from these therapies with the aid of cardiac imaging. Methods: This is a single-centre, prospective clinical trial. Patients with NSCLC who are enrolled will undergo computed tomography (CT) and magnetic resonance imaging (MRI) before chemotherapy 3 months, 6 months, and 9–12 months after the treatment. We expect to enrol 30 patients in 2 years. Conclusions: Our clinical trial will be an opportunity not only to highlight the timing and the radiation dose needed for pathological cardiac tissue changes to happen but will also provide useful data to set new follow-up schedules and strategies, keeping in mind that, more often than not, patients affected by NSCLC may present other heart- and lung-related pathological conditions.https://www.mdpi.com/2075-4418/13/10/1717NSCLCradiotherapythoracic imagingcardiac MRIcardiac CT |
| spellingShingle | Valerio Nardone Maria Paola Belfiore Marco De Chiara Giuseppina De Marco Vittorio Patanè Giovanni Balestrucci Mauro Buono Maria Salvarezza Gaetano Di Guida Domenico D’Angiolella Roberta Grassi Ida D’Onofrio Giovanni Cimmino Carminia Maria Della Corte Antonio Gambardella Floriana Morgillo Fortunato Ciardiello Alfonso Reginelli Salvatore Cappabianca CARdioimaging in Lung Cancer PatiEnts Undergoing Radical RadioTherapy: CARE-RT Trial Diagnostics NSCLC radiotherapy thoracic imaging cardiac MRI cardiac CT |
| title | CARdioimaging in Lung Cancer PatiEnts Undergoing Radical RadioTherapy: CARE-RT Trial |
| title_full | CARdioimaging in Lung Cancer PatiEnts Undergoing Radical RadioTherapy: CARE-RT Trial |
| title_fullStr | CARdioimaging in Lung Cancer PatiEnts Undergoing Radical RadioTherapy: CARE-RT Trial |
| title_full_unstemmed | CARdioimaging in Lung Cancer PatiEnts Undergoing Radical RadioTherapy: CARE-RT Trial |
| title_short | CARdioimaging in Lung Cancer PatiEnts Undergoing Radical RadioTherapy: CARE-RT Trial |
| title_sort | cardioimaging in lung cancer patients undergoing radical radiotherapy care rt trial |
| topic | NSCLC radiotherapy thoracic imaging cardiac MRI cardiac CT |
| url | https://www.mdpi.com/2075-4418/13/10/1717 |
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