A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

Hundreds of human genes are associated with neurological diseases, but translation into tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to investigate genetic contributions to neurological diseases. However, current CRISPR-Cas9 methods are difficult to apply to l...

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Bibliographic Details
Main Authors: François Kroll, Gareth T Powell, Marcus Ghosh, Gaia Gestri, Paride Antinucci, Timothy J Hearn, Hande Tunbak, Sumi Lim, Harvey W Dennis, Joseph M Fernandez, David Whitmore, Elena Dreosti, Stephen W Wilson, Ellen J Hoffman, Jason Rihel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
behaviour
circadian rhythm
sleep
knockout
G0
CRISPR
Online Access:https://elifesciences.org/articles/59683

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