Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature
Brenner tumors (BTs) are surface-epithelial stromal cell tumors that are categorized by the World Health Organization as benign, borderline, and malignant. Due to the rarity of BTs, the published literature on these tumors is comprised primarily of case reports and small retrospective studies. We pe...
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MDPI AG
2023-02-01
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| Series: | Medical Sciences |
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| Online Access: | https://www.mdpi.com/2076-3271/11/1/18 |
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| author | Ferial Alloush Hisham F. Bahmad Brendan Lutz Robert Poppiti Monica Recine Sarah Alghamdi Larry E. Goldenberg |
| author_facet | Ferial Alloush Hisham F. Bahmad Brendan Lutz Robert Poppiti Monica Recine Sarah Alghamdi Larry E. Goldenberg |
| author_sort | Ferial Alloush |
| collection | DOAJ |
| description | Brenner tumors (BTs) are surface-epithelial stromal cell tumors that are categorized by the World Health Organization as benign, borderline, and malignant. Due to the rarity of BTs, the published literature on these tumors is comprised primarily of case reports and small retrospective studies. We performed a pathology database review spanning the last ten years at our institution revealing nine reported benign BTs. We collected the clinical and pathological data of patients associated with those BTs, describing the clinical presentation and imaging results, and assessing the possible risk factors associated with them. The average age at diagnosis was 58 years. BTs were discovered incidentally in 7/9 cases. The tumor was multifocal and bilateral in 1/9 cases and ranged in size from 0.2 cm to 7.5 cm. Associated Walthard rests were found in 6/9 cases and transitional metaplasia of surface ovarian and/or tubal epithelium was found in 4/9 cases. One patient had an associated mucinous cystadenoma in the ipsilateral ovary. Another patient had an associated mucinous cystadenoma in the contralateral ovary. In conclusion, we found that Walthard rests and transitional metaplasia are common findings in association with BTs. Additionally, pathologists and surgeons need to be aware of the association between mucinous cystadenomas and BTs. |
| first_indexed | 2024-03-11T06:12:05Z |
| format | Article |
| id | doaj.art-25c5f5bca3b14887b87ded466cf1515e |
| institution | Directory Open Access Journal |
| issn | 2076-3271 |
| language | English |
| last_indexed | 2024-03-11T06:12:05Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences |
| spelling | doaj.art-25c5f5bca3b14887b87ded466cf1515e2023-11-17T12:33:51ZengMDPI AGMedical Sciences2076-32712023-02-011111810.3390/medsci11010018Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the LiteratureFerial Alloush0Hisham F. Bahmad1Brendan Lutz2Robert Poppiti3Monica Recine4Sarah Alghamdi5Larry E. Goldenberg6Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USAArkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USADepartment of Obstetrics and Gynecology, Mount Sinai Medical Center, Miami Beach, FL 33140, USAArkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USAArkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USAArkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USADepartment of Obstetrics and Gynecology, Mount Sinai Medical Center, Miami Beach, FL 33140, USABrenner tumors (BTs) are surface-epithelial stromal cell tumors that are categorized by the World Health Organization as benign, borderline, and malignant. Due to the rarity of BTs, the published literature on these tumors is comprised primarily of case reports and small retrospective studies. We performed a pathology database review spanning the last ten years at our institution revealing nine reported benign BTs. We collected the clinical and pathological data of patients associated with those BTs, describing the clinical presentation and imaging results, and assessing the possible risk factors associated with them. The average age at diagnosis was 58 years. BTs were discovered incidentally in 7/9 cases. The tumor was multifocal and bilateral in 1/9 cases and ranged in size from 0.2 cm to 7.5 cm. Associated Walthard rests were found in 6/9 cases and transitional metaplasia of surface ovarian and/or tubal epithelium was found in 4/9 cases. One patient had an associated mucinous cystadenoma in the ipsilateral ovary. Another patient had an associated mucinous cystadenoma in the contralateral ovary. In conclusion, we found that Walthard rests and transitional metaplasia are common findings in association with BTs. Additionally, pathologists and surgeons need to be aware of the association between mucinous cystadenomas and BTs.https://www.mdpi.com/2076-3271/11/1/18Brenner tumorovaryWalthard restsmucinous cystadenomacase series |
| spellingShingle | Ferial Alloush Hisham F. Bahmad Brendan Lutz Robert Poppiti Monica Recine Sarah Alghamdi Larry E. Goldenberg Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature Medical Sciences Brenner tumor ovary Walthard rests mucinous cystadenoma case series |
| title | Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature |
| title_full | Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature |
| title_fullStr | Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature |
| title_full_unstemmed | Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature |
| title_short | Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature |
| title_sort | brenner tumor of the ovary a 10 year single institution experience and comprehensive review of the literature |
| topic | Brenner tumor ovary Walthard rests mucinous cystadenoma case series |
| url | https://www.mdpi.com/2076-3271/11/1/18 |
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