The hypoxia adaptation of small mammals to plateau and underground burrow conditions
Abstract Oxygen is one of the important substances for the survival of most life systems on the earth, and plateau and underground burrow systems are two typical hypoxic environments. Small mammals living in hypoxic environments have evolved different adaptation strategies, which include increased o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-12-01
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| Series: | Animal Models and Experimental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ame2.12183 |
| _version_ | 1819320369789534208 |
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| author | Mengke Li Dan Pan Hong Sun Lei Zhang Han Cheng Tian Shao Zhenlong Wang |
| author_facet | Mengke Li Dan Pan Hong Sun Lei Zhang Han Cheng Tian Shao Zhenlong Wang |
| author_sort | Mengke Li |
| collection | DOAJ |
| description | Abstract Oxygen is one of the important substances for the survival of most life systems on the earth, and plateau and underground burrow systems are two typical hypoxic environments. Small mammals living in hypoxic environments have evolved different adaptation strategies, which include increased oxygen delivery, metabolic regulation of physiological responses and other physiological responses that change tissue oxygen utilization. Multi‐omics predictions have also shown that these animals have evolved different adaptations to extreme environments. In particular, vascular endothelial growth factor (VEGF) and erythropoietin (EPO), which have specific functions in the control of O2 delivery, have evolved adaptively in small mammals in hypoxic environments. Naked mole‐rats and blind mole‐rats are typical hypoxic model animals as they have some resistance to cancer. This review primarily summarizes the main living environment of hypoxia tolerant small mammals, as well as the changes of phenotype, physiochemical characteristics and gene expression mode of their long‐term living in hypoxia environment. |
| first_indexed | 2024-12-24T11:18:29Z |
| format | Article |
| id | doaj.art-25c5fab6979341bcb41b9ea94e67844e |
| institution | Directory Open Access Journal |
| issn | 2576-2095 |
| language | English |
| last_indexed | 2024-12-24T11:18:29Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj.art-25c5fab6979341bcb41b9ea94e67844e2022-12-21T16:58:18ZengWileyAnimal Models and Experimental Medicine2576-20952021-12-014431932810.1002/ame2.12183The hypoxia adaptation of small mammals to plateau and underground burrow conditionsMengke Li0Dan Pan1Hong Sun2Lei Zhang3Han Cheng4Tian Shao5Zhenlong Wang6School of Life Sciences Zhengzhou University Zhengzhou P.R. ChinaSchool of Life Sciences Zhengzhou University Zhengzhou P.R. ChinaSchool of Life Sciences Zhengzhou University Zhengzhou P.R. ChinaSchool of Life Sciences Zhengzhou University Zhengzhou P.R. ChinaSchool of Life Sciences Zhengzhou University Zhengzhou P.R. ChinaSchool of Life Sciences Zhengzhou University Zhengzhou P.R. ChinaSchool of Life Sciences Zhengzhou University Zhengzhou P.R. ChinaAbstract Oxygen is one of the important substances for the survival of most life systems on the earth, and plateau and underground burrow systems are two typical hypoxic environments. Small mammals living in hypoxic environments have evolved different adaptation strategies, which include increased oxygen delivery, metabolic regulation of physiological responses and other physiological responses that change tissue oxygen utilization. Multi‐omics predictions have also shown that these animals have evolved different adaptations to extreme environments. In particular, vascular endothelial growth factor (VEGF) and erythropoietin (EPO), which have specific functions in the control of O2 delivery, have evolved adaptively in small mammals in hypoxic environments. Naked mole‐rats and blind mole‐rats are typical hypoxic model animals as they have some resistance to cancer. This review primarily summarizes the main living environment of hypoxia tolerant small mammals, as well as the changes of phenotype, physiochemical characteristics and gene expression mode of their long‐term living in hypoxia environment.https://doi.org/10.1002/ame2.12183hypoxia adaptationmulti‐omicsplateausmall mammalsunderground burrow systems |
| spellingShingle | Mengke Li Dan Pan Hong Sun Lei Zhang Han Cheng Tian Shao Zhenlong Wang The hypoxia adaptation of small mammals to plateau and underground burrow conditions Animal Models and Experimental Medicine hypoxia adaptation multi‐omics plateau small mammals underground burrow systems |
| title | The hypoxia adaptation of small mammals to plateau and underground burrow conditions |
| title_full | The hypoxia adaptation of small mammals to plateau and underground burrow conditions |
| title_fullStr | The hypoxia adaptation of small mammals to plateau and underground burrow conditions |
| title_full_unstemmed | The hypoxia adaptation of small mammals to plateau and underground burrow conditions |
| title_short | The hypoxia adaptation of small mammals to plateau and underground burrow conditions |
| title_sort | hypoxia adaptation of small mammals to plateau and underground burrow conditions |
| topic | hypoxia adaptation multi‐omics plateau small mammals underground burrow systems |
| url | https://doi.org/10.1002/ame2.12183 |
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