Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-Analysis
Background:Conflicting findings of the association between serum uric acid (SUA) and atrial fibrillation (AF) have been reported in both men and women. The sex-specific associations between SUA and the risk of AF are unclear, although hyperuricemia is independently associated with the risk of AF. We...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.865036/full |
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| author | Jianhua Xiong Jianhua Xiong Wen Shao Peng Yu Jianyong Ma Menglu Liu Shan Huang Xiao Liu Xiao Liu Kaibo Mei |
| author_facet | Jianhua Xiong Jianhua Xiong Wen Shao Peng Yu Jianyong Ma Menglu Liu Shan Huang Xiao Liu Xiao Liu Kaibo Mei |
| author_sort | Jianhua Xiong |
| collection | DOAJ |
| description | Background:Conflicting findings of the association between serum uric acid (SUA) and atrial fibrillation (AF) have been reported in both men and women. The sex-specific associations between SUA and the risk of AF are unclear, although hyperuricemia is independently associated with the risk of AF. We performed this meta-analysis to assess the sex-specific effect of SUA on the risk of AF.MethodsThe PubMed, EMBASE, and Cochrane Library databases were searched up to October 3, 2021, for studies that reported sex-specific associations of SUA levels with AF. Linear relationships were assessed by the generalized least squares trend estimation. This study was registered with PROSPERO (42020193013).ResultsTen eligible studies with 814,804 participants (415,779 men and 399,025 women) were identified. In the category analysis, high SUA was associated with an increased risk of AF in both men (OR: 1.42; 95% CI, 1.18–1.71, I2 = 34%) and women (OR: 2.02; 95% CI, 1.29–3.16, I2 = 70%). In the dose-response analysis, for each 60 μmol/L (1 mg/dL) increase in the SUA level, the risk of AF increased by 15% (OR: 1.15; 95% CI, 1.07–1.25, I2 = 74%) in men and 35% (OR: 1.35; 95% CI, 1.18–1.53, I2 = 73%) in women. There was a borderline difference in the impact of SUA on the risk of AF between men and women (P for interaction = 0.05). A significant linear relationship between SUA and the risk of AF was observed in men (P for non-linearity = 0.91) and women (P for non-linearity = 0.92).ConclusionsThis study suggested that there was a significant linear relationship between SUA and the risk of AF among men and women, with a higher risk estimate for women. Additional trials are required to assess the effect of reduced SUA therapy on AF incidence.Systematic Review Registrationhttps:www.crd.york.ac.uk/PROSPERO/, identifier: CRD 42020193013. |
| first_indexed | 2024-12-13T22:07:11Z |
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| id | doaj.art-25c6cad8d87a4f638afd701747138d5a |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-13T22:07:11Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-25c6cad8d87a4f638afd701747138d5a2022-12-21T23:29:48ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-04-01910.3389/fcvm.2022.865036865036Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-AnalysisJianhua Xiong0Jianhua Xiong1Wen Shao2Peng Yu3Jianyong Ma4Menglu Liu5Shan Huang6Xiao Liu7Xiao Liu8Kaibo Mei9Department of Cardiology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, ChinaKey Laboratory of Cardiovascular Diseases in Chinese Medicine, Nanchang, ChinaDepartment of Endocrine, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Endocrine, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United StatesDepartment of Cardiology, The Seventh Hospital of Zhengzhou, Zhengzhou, ChinaDepartment of Psychiatry, The Third People's Hospital of Gan Zhou, Ganzhou, ChinaDepartment of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, ChinaGuangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, ChinaDepartment of Anesthesia, The People's Hospital of Shangrao, Shangrao, ChinaBackground:Conflicting findings of the association between serum uric acid (SUA) and atrial fibrillation (AF) have been reported in both men and women. The sex-specific associations between SUA and the risk of AF are unclear, although hyperuricemia is independently associated with the risk of AF. We performed this meta-analysis to assess the sex-specific effect of SUA on the risk of AF.MethodsThe PubMed, EMBASE, and Cochrane Library databases were searched up to October 3, 2021, for studies that reported sex-specific associations of SUA levels with AF. Linear relationships were assessed by the generalized least squares trend estimation. This study was registered with PROSPERO (42020193013).ResultsTen eligible studies with 814,804 participants (415,779 men and 399,025 women) were identified. In the category analysis, high SUA was associated with an increased risk of AF in both men (OR: 1.42; 95% CI, 1.18–1.71, I2 = 34%) and women (OR: 2.02; 95% CI, 1.29–3.16, I2 = 70%). In the dose-response analysis, for each 60 μmol/L (1 mg/dL) increase in the SUA level, the risk of AF increased by 15% (OR: 1.15; 95% CI, 1.07–1.25, I2 = 74%) in men and 35% (OR: 1.35; 95% CI, 1.18–1.53, I2 = 73%) in women. There was a borderline difference in the impact of SUA on the risk of AF between men and women (P for interaction = 0.05). A significant linear relationship between SUA and the risk of AF was observed in men (P for non-linearity = 0.91) and women (P for non-linearity = 0.92).ConclusionsThis study suggested that there was a significant linear relationship between SUA and the risk of AF among men and women, with a higher risk estimate for women. Additional trials are required to assess the effect of reduced SUA therapy on AF incidence.Systematic Review Registrationhttps:www.crd.york.ac.uk/PROSPERO/, identifier: CRD 42020193013.https://www.frontiersin.org/articles/10.3389/fcvm.2022.865036/fullatrial fibrillationserum uric acidsex differencemeta-analysishyperuricemia |
| spellingShingle | Jianhua Xiong Jianhua Xiong Wen Shao Peng Yu Jianyong Ma Menglu Liu Shan Huang Xiao Liu Xiao Liu Kaibo Mei Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-Analysis Frontiers in Cardiovascular Medicine atrial fibrillation serum uric acid sex difference meta-analysis hyperuricemia |
| title | Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-Analysis |
| title_full | Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-Analysis |
| title_fullStr | Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-Analysis |
| title_full_unstemmed | Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-Analysis |
| title_short | Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-Analysis |
| title_sort | hyperuricemia is associated with the risk of atrial fibrillation independent of sex a dose response meta analysis |
| topic | atrial fibrillation serum uric acid sex difference meta-analysis hyperuricemia |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.865036/full |
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