Association between serum vitamin A levels and premature ovarian insufficiency: a case–control, cross-sectional survey study
Abstract Background Although vitamin A is known to play an important role in ovarian function, its association with ovarian insufficiency has not been reported yet. Therefore, the aim of the study was to explore the association between serum vitamin A levels and premature ovarian insufficiency (POI)...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-01003-9 |
| _version_ | 1811290517289304064 |
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| author | Peiqiong Chen Yang Song Wenxian Xu Yizhou Huang Yingxian Jia Chunming Li Yibing Lan Ketan Chu Linjuan Ma Jianhong Zhou |
| author_facet | Peiqiong Chen Yang Song Wenxian Xu Yizhou Huang Yingxian Jia Chunming Li Yibing Lan Ketan Chu Linjuan Ma Jianhong Zhou |
| author_sort | Peiqiong Chen |
| collection | DOAJ |
| description | Abstract Background Although vitamin A is known to play an important role in ovarian function, its association with ovarian insufficiency has not been reported yet. Therefore, the aim of the study was to explore the association between serum vitamin A levels and premature ovarian insufficiency (POI). Methods This cross-sectional survey included women with POI (n = 47) and normo-ovulatory controls (n = 67) who were enrolled between December 2016 and May 2018 in Zhejiang, China. The serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti-Müllerian hormone (AMH), vitamin A, and total cholesterol (TC) were measured for each participant. The association of TC-adjusted vitamin A levels with the risk of POI was assessed using binary logistic regression analysis. Results Serum vitamin A levels appeared to be slightly higher in the POI group than in the control group, but there was no evidence of a statistically significant difference (728.00 ± 176.00 µg/L vs. 503.93 ± 145.64 µg/L, p = 0.13). After adjustment for serum lipid levels, the serum vitamin A/TC ratio was significantly lower in the POI group than in the control group (143.14 ± 35.86 vs. 157.56 ± 35.21 µg/mmol, p = 0.04). Further, the serum vitamin A/TC ratio was significantly and inversely associated with POI risk (unadjusted odds ratio [OR] = 0.988, 95% confidence interval [CI]: 0.977–0.999, p = 0.04). The association remained after adjusting for confounding factors (age, BMI, annual household income, and education) (OR = 0.986, 95% CI: 0.972–0.999, p = 0.04). Conclusions Serum vitamin A/TC ratio was inversely associated with POI risk. Therefore, the serum vitamin A/TC ratio may serve as a predictive factor for POI, and vitamin A supplementation may play help prevent or treat POI. |
| first_indexed | 2024-04-13T04:14:03Z |
| format | Article |
| id | doaj.art-25c780f795aa47bea8847e5f3f680af7 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-13T04:14:03Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-25c780f795aa47bea8847e5f3f680af72022-12-22T03:03:02ZengBMCBMC Endocrine Disorders1472-68232022-04-012211710.1186/s12902-022-01003-9Association between serum vitamin A levels and premature ovarian insufficiency: a case–control, cross-sectional survey studyPeiqiong Chen0Yang Song1Wenxian Xu2Yizhou Huang3Yingxian Jia4Chunming Li5Yibing Lan6Ketan Chu7Linjuan Ma8Jianhong Zhou9Department of Gynecology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecology, Women’s Hospital, Zhejiang University School of MedicineAbstract Background Although vitamin A is known to play an important role in ovarian function, its association with ovarian insufficiency has not been reported yet. Therefore, the aim of the study was to explore the association between serum vitamin A levels and premature ovarian insufficiency (POI). Methods This cross-sectional survey included women with POI (n = 47) and normo-ovulatory controls (n = 67) who were enrolled between December 2016 and May 2018 in Zhejiang, China. The serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti-Müllerian hormone (AMH), vitamin A, and total cholesterol (TC) were measured for each participant. The association of TC-adjusted vitamin A levels with the risk of POI was assessed using binary logistic regression analysis. Results Serum vitamin A levels appeared to be slightly higher in the POI group than in the control group, but there was no evidence of a statistically significant difference (728.00 ± 176.00 µg/L vs. 503.93 ± 145.64 µg/L, p = 0.13). After adjustment for serum lipid levels, the serum vitamin A/TC ratio was significantly lower in the POI group than in the control group (143.14 ± 35.86 vs. 157.56 ± 35.21 µg/mmol, p = 0.04). Further, the serum vitamin A/TC ratio was significantly and inversely associated with POI risk (unadjusted odds ratio [OR] = 0.988, 95% confidence interval [CI]: 0.977–0.999, p = 0.04). The association remained after adjusting for confounding factors (age, BMI, annual household income, and education) (OR = 0.986, 95% CI: 0.972–0.999, p = 0.04). Conclusions Serum vitamin A/TC ratio was inversely associated with POI risk. Therefore, the serum vitamin A/TC ratio may serve as a predictive factor for POI, and vitamin A supplementation may play help prevent or treat POI.https://doi.org/10.1186/s12902-022-01003-9Vitamin ARetinoid signalingPremature ovarian insufficiencyAnti-Müllerian hormone |
| spellingShingle | Peiqiong Chen Yang Song Wenxian Xu Yizhou Huang Yingxian Jia Chunming Li Yibing Lan Ketan Chu Linjuan Ma Jianhong Zhou Association between serum vitamin A levels and premature ovarian insufficiency: a case–control, cross-sectional survey study BMC Endocrine Disorders Vitamin A Retinoid signaling Premature ovarian insufficiency Anti-Müllerian hormone |
| title | Association between serum vitamin A levels and premature ovarian insufficiency: a case–control, cross-sectional survey study |
| title_full | Association between serum vitamin A levels and premature ovarian insufficiency: a case–control, cross-sectional survey study |
| title_fullStr | Association between serum vitamin A levels and premature ovarian insufficiency: a case–control, cross-sectional survey study |
| title_full_unstemmed | Association between serum vitamin A levels and premature ovarian insufficiency: a case–control, cross-sectional survey study |
| title_short | Association between serum vitamin A levels and premature ovarian insufficiency: a case–control, cross-sectional survey study |
| title_sort | association between serum vitamin a levels and premature ovarian insufficiency a case control cross sectional survey study |
| topic | Vitamin A Retinoid signaling Premature ovarian insufficiency Anti-Müllerian hormone |
| url | https://doi.org/10.1186/s12902-022-01003-9 |
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