The Role of P53 in Oral Cancer - A Review
P53 is a nuclear phosphoprotein encoded by the tumor suppressor gene p53. This P53 protein plays an important role in the regulation of normal cell proliferation by causing cell cycle arrest. Mutation of p53 gene produces an altered P53 protein leading to loss of cell cycle control. As a result, the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2005-01-01
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| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
| Subjects: | |
| Online Access: | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2005;volume=17;issue=4;spage=153;epage=156;aulast=Poornima;type=0 |
| _version_ | 1818977787767160832 |
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| author | C Poornima P G Agnihotri S Y Rajan B N Padmavathi R Guruprasad |
| author_facet | C Poornima P G Agnihotri S Y Rajan B N Padmavathi R Guruprasad |
| author_sort | C Poornima |
| collection | DOAJ |
| description | P53 is a nuclear phosphoprotein encoded by the tumor suppressor gene p53. This P53 protein plays an important role in the regulation of normal cell proliferation by causing cell cycle arrest. Mutation of p53 gene produces an altered P53 protein leading to loss of cell cycle control. As a result, there is an uncontrolled cell proliferation, which may lead to the development of cancer. Mutation of the p53 gene is one of the commonest genetic changes in human cancers.
This article reviews the basic structure, functions and the role of P53 in oral cancer. |
| first_indexed | 2024-12-20T16:33:18Z |
| format | Article |
| id | doaj.art-25c7c6bd16e440ed8362ca9ee4b9f58a |
| institution | Directory Open Access Journal |
| issn | 0972-1363 0975-1572 |
| language | English |
| last_indexed | 2024-12-20T16:33:18Z |
| publishDate | 2005-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Academy of Oral Medicine and Radiology |
| spelling | doaj.art-25c7c6bd16e440ed8362ca9ee4b9f58a2022-12-21T19:33:12ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13630975-15722005-01-01174153156The Role of P53 in Oral Cancer - A ReviewC PoornimaP G AgnihotriS Y RajanB N PadmavathiR GuruprasadP53 is a nuclear phosphoprotein encoded by the tumor suppressor gene p53. This P53 protein plays an important role in the regulation of normal cell proliferation by causing cell cycle arrest. Mutation of p53 gene produces an altered P53 protein leading to loss of cell cycle control. As a result, there is an uncontrolled cell proliferation, which may lead to the development of cancer. Mutation of the p53 gene is one of the commonest genetic changes in human cancers. This article reviews the basic structure, functions and the role of P53 in oral cancer.http://www.jiaomr.in/article.asp?issn=0972-1363;year=2005;volume=17;issue=4;spage=153;epage=156;aulast=Poornima;type=0Tumor suppressor genep53 geneP53 proteinCell cycle arrestApoptosis |
| spellingShingle | C Poornima P G Agnihotri S Y Rajan B N Padmavathi R Guruprasad The Role of P53 in Oral Cancer - A Review Journal of Indian Academy of Oral Medicine and Radiology Tumor suppressor gene p53 gene P53 protein Cell cycle arrest Apoptosis |
| title | The Role of P53 in Oral Cancer - A Review |
| title_full | The Role of P53 in Oral Cancer - A Review |
| title_fullStr | The Role of P53 in Oral Cancer - A Review |
| title_full_unstemmed | The Role of P53 in Oral Cancer - A Review |
| title_short | The Role of P53 in Oral Cancer - A Review |
| title_sort | role of p53 in oral cancer a review |
| topic | Tumor suppressor gene p53 gene P53 protein Cell cycle arrest Apoptosis |
| url | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2005;volume=17;issue=4;spage=153;epage=156;aulast=Poornima;type=0 |
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