Defensins: Potential Effectors in Autoimmune Rheumatic Disorders
Defensins are small cationic peptides with antimicrobial properties. They constitute a highly conserved innate immune defense mechanism across species. Based on the arrangement of disulfide-bonds, α- and β-defensins are distinguished in humans. Both types of defensin comprise several distinct molecu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-08-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2073-4360/3/3/1268/ |
| _version_ | 1811303242655596544 |
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| author | Stefan Vordenbäumen Matthias Schneider |
| author_facet | Stefan Vordenbäumen Matthias Schneider |
| author_sort | Stefan Vordenbäumen |
| collection | DOAJ |
| description | Defensins are small cationic peptides with antimicrobial properties. They constitute a highly conserved innate immune defense mechanism across species. Based on the arrangement of disulfide-bonds, α- and β-defensins are distinguished in humans. Both types of defensin comprise several distinct molecules that are preferentially expressed at epithelial surfaces and in blood cells. In the last decade, multiple immunomodulatory functions of defensins have been recognized, including chemotactic activity, the promotion of antigen presentation, and modulations of proinflammatory cytokine secretion. These findings suggested a role for defensins not only as a first line of defense, but also as connectors of innate and adaptive immune responses. Recently, increasingly accumulating evidence has indicated that defensins may also be involved in the pathogenesis of autoimmune rheumatic disorders such as systemic lupus erythematosus and rheumatoid arthritis. The current review summarizes the data connecting defensins to autoimmunity. |
| first_indexed | 2024-04-13T07:44:31Z |
| format | Article |
| id | doaj.art-25c7eda49bd04854b2123cdd7bd29f57 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-04-13T07:44:31Z |
| publishDate | 2011-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-25c7eda49bd04854b2123cdd7bd29f572022-12-22T02:55:44ZengMDPI AGPolymers2073-43602011-08-01331268128110.3390/polym3031268Defensins: Potential Effectors in Autoimmune Rheumatic DisordersStefan VordenbäumenMatthias SchneiderDefensins are small cationic peptides with antimicrobial properties. They constitute a highly conserved innate immune defense mechanism across species. Based on the arrangement of disulfide-bonds, α- and β-defensins are distinguished in humans. Both types of defensin comprise several distinct molecules that are preferentially expressed at epithelial surfaces and in blood cells. In the last decade, multiple immunomodulatory functions of defensins have been recognized, including chemotactic activity, the promotion of antigen presentation, and modulations of proinflammatory cytokine secretion. These findings suggested a role for defensins not only as a first line of defense, but also as connectors of innate and adaptive immune responses. Recently, increasingly accumulating evidence has indicated that defensins may also be involved in the pathogenesis of autoimmune rheumatic disorders such as systemic lupus erythematosus and rheumatoid arthritis. The current review summarizes the data connecting defensins to autoimmunity.http://www.mdpi.com/2073-4360/3/3/1268/defensinantimicrobial peptiderheumatologyautoimmune disease |
| spellingShingle | Stefan Vordenbäumen Matthias Schneider Defensins: Potential Effectors in Autoimmune Rheumatic Disorders Polymers defensin antimicrobial peptide rheumatology autoimmune disease |
| title | Defensins: Potential Effectors in Autoimmune Rheumatic Disorders |
| title_full | Defensins: Potential Effectors in Autoimmune Rheumatic Disorders |
| title_fullStr | Defensins: Potential Effectors in Autoimmune Rheumatic Disorders |
| title_full_unstemmed | Defensins: Potential Effectors in Autoimmune Rheumatic Disorders |
| title_short | Defensins: Potential Effectors in Autoimmune Rheumatic Disorders |
| title_sort | defensins potential effectors in autoimmune rheumatic disorders |
| topic | defensin antimicrobial peptide rheumatology autoimmune disease |
| url | http://www.mdpi.com/2073-4360/3/3/1268/ |
| work_keys_str_mv | AT stefanvordenbaumen defensinspotentialeffectorsinautoimmunerheumaticdisorders AT matthiasschneider defensinspotentialeffectorsinautoimmunerheumaticdisorders |