Morphological and metabolic changes in the nigro-striatal pathway of synthetic proteasome inhibitor (PSI)-treated rats: a MRI and MRS study.

Morphological and metabolic changes in the nigro-striatal pathway of synthetic proteasome inhibitor (PSI)-treated rats: a MRI and MRS study.

Systemic administration of a Synthetic Proteasome Inhibitor (PSI) in rats has been described as able to provide a model of Parkinson's disease (PD), characterized by behavioral and biochemical modifications, including loss of dopaminergic neurons in the substantia nigra (SN), as assessed by pos...

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Main Authors: Stefano Delli Pizzi, Cosmo Rossi, Vincenzo Di Matteo, Ennio Esposito, Simone Guarnieri, Maria Addolorata Mariggiò, Raffaella Franciotti, Massimo Caulo, Astrid Thomas, Marco Onofrj, Armando Tartaro, Laura Bonanni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3576393?pdf=render

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