14-3-3 Activated Bacterial Exotoxins AexT and ExoT Share Actin and the SH2 Domains of CRK Proteins as Targets for ADP-Ribosylation

14-3-3 Activated Bacterial Exotoxins AexT and ExoT Share Actin and the SH2 Domains of CRK Proteins as Targets for ADP-Ribosylation

Bacterial exotoxins with ADP-ribosyltransferase activity can be divided into distinct clades based on their domain organization. Exotoxins from several clades are known to modify actin at Arg177; but of the 14-3-3 dependent exotoxins only <i>Aeromonas salmonicida</i> exoenzyme T (AexT) h...

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Bibliographic Details
Main Authors: Carmen Ebenwaldner, Peter Hornyak, Antonio Ginés García-Saura, Archimede Torretta, Saber Anoosheh, Anders Hofer, Herwig Schüler
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pathogens
Subjects:
14-3-3 activated bacterial exotoxins
actin
ADP-ribosylation
<i>Aeromonas salmonicid</i>
protein refolding
type III secretion system
Online Access:https://www.mdpi.com/2076-0817/11/12/1497

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