Napsin A and Thyroid Transcription Factor-1-Positive Cerebellar Tumor with Epidermal Growth Factor Receptor Mutation
We present a very rare case of cerebellar metastasis of unknown origin, in which a primary lung adenocarcinoma was diagnosed by pathological examination of a cerebellar metastatic tumor, using immunohistochemical markers and epidermal growth factor receptor (EGFR) mutation of primary lung cancer. A...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2011-12-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/334925 |
| _version_ | 1811197944667308032 |
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| author | Taiji Kuwata Teruo Iwata Takashi Iwanami |
| author_facet | Taiji Kuwata Teruo Iwata Takashi Iwanami |
| author_sort | Taiji Kuwata |
| collection | DOAJ |
| description | We present a very rare case of cerebellar metastasis of unknown origin, in which a primary lung adenocarcinoma was diagnosed by pathological examination of a cerebellar metastatic tumor, using immunohistochemical markers and epidermal growth factor receptor (EGFR) mutation of primary lung cancer. A 69-year-old woman was admitted to our hospital because of a hemorrhagic cerebellar tumor and multiple small brain tumors. She underwent cerebellar tumor resection. On pathological examination, the tumor was diagnosed as adenocarcinoma. However, the primary tumor site was unidentifiable even with several imaging inspections. On immunohistochemical analysis, the resected tumor was positive for napsin A and thyroid transcription factor-1. In addition, an EGFR mutation was detected in the tumor. Therefore, primary lung cancer was diagnosed and the patient was started on gefitinib (250 mg/day) therapy. |
| first_indexed | 2024-04-12T01:22:56Z |
| format | Article |
| id | doaj.art-25ccd1ced53f456eafdef3f2b0457aee |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-12T01:22:56Z |
| publishDate | 2011-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-25ccd1ced53f456eafdef3f2b0457aee2022-12-22T03:53:43ZengKarger PublishersCase Reports in Oncology1662-65752011-12-014356456810.1159/000334925334925Napsin A and Thyroid Transcription Factor-1-Positive Cerebellar Tumor with Epidermal Growth Factor Receptor MutationTaiji KuwataTeruo IwataTakashi IwanamiWe present a very rare case of cerebellar metastasis of unknown origin, in which a primary lung adenocarcinoma was diagnosed by pathological examination of a cerebellar metastatic tumor, using immunohistochemical markers and epidermal growth factor receptor (EGFR) mutation of primary lung cancer. A 69-year-old woman was admitted to our hospital because of a hemorrhagic cerebellar tumor and multiple small brain tumors. She underwent cerebellar tumor resection. On pathological examination, the tumor was diagnosed as adenocarcinoma. However, the primary tumor site was unidentifiable even with several imaging inspections. On immunohistochemical analysis, the resected tumor was positive for napsin A and thyroid transcription factor-1. In addition, an EGFR mutation was detected in the tumor. Therefore, primary lung cancer was diagnosed and the patient was started on gefitinib (250 mg/day) therapy.http://www.karger.com/Article/FullText/334925Cerebral metastasesLung adenocarcinomaEpidermal growth factor receptor mutation |
| spellingShingle | Taiji Kuwata Teruo Iwata Takashi Iwanami Napsin A and Thyroid Transcription Factor-1-Positive Cerebellar Tumor with Epidermal Growth Factor Receptor Mutation Case Reports in Oncology Cerebral metastases Lung adenocarcinoma Epidermal growth factor receptor mutation |
| title | Napsin A and Thyroid Transcription Factor-1-Positive Cerebellar Tumor with Epidermal Growth Factor Receptor Mutation |
| title_full | Napsin A and Thyroid Transcription Factor-1-Positive Cerebellar Tumor with Epidermal Growth Factor Receptor Mutation |
| title_fullStr | Napsin A and Thyroid Transcription Factor-1-Positive Cerebellar Tumor with Epidermal Growth Factor Receptor Mutation |
| title_full_unstemmed | Napsin A and Thyroid Transcription Factor-1-Positive Cerebellar Tumor with Epidermal Growth Factor Receptor Mutation |
| title_short | Napsin A and Thyroid Transcription Factor-1-Positive Cerebellar Tumor with Epidermal Growth Factor Receptor Mutation |
| title_sort | napsin a and thyroid transcription factor 1 positive cerebellar tumor with epidermal growth factor receptor mutation |
| topic | Cerebral metastases Lung adenocarcinoma Epidermal growth factor receptor mutation |
| url | http://www.karger.com/Article/FullText/334925 |
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