PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma.

PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma.

Neuroblastoma (NB) is a severe pediatric tumor originating from neural crest derivatives and accounting for 15% of childhood cancer mortality. The heterogeneous and complex genetic etiology has been confirmed with the identification of mutations in two genes, encoding for the receptor tyrosine kinas...

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Main Authors: Tiziana Bachetti, Daniela Di Paolo, Simona Di Lascio, Valentina Mirisola, Chiara Brignole, Marta Bellotti, Irene Caffa, Chiara Ferraris, Michele Fiore, Diego Fornasari, Roberto Chiarle, Silvia Borghini, Ulrich Pfeffer, Mirco Ponzoni, Isabella Ceccherini, Patrizia Perri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20957039/pdf/?tool=EBI

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