DNA minicircles as novel STAT3 decoy oligodeoxynucleotides endowed with anticancer activity in triple-negative breast cancer

DNA minicircles as novel STAT3 decoy oligodeoxynucleotides endowed with anticancer activity in triple-negative breast cancer

Decoy technology is a versatile and specific DNA oligonucleotide-based targeting strategy of pathogenic transcription factors (TFs). Chemical modifications of linear decoy oligonucleotides have been made to decrease nuclease sensitivity because of the presence of free ends but at the cost of new lim...

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Bibliographic Details
Main Authors: Geoffrey Casas, Federico Perche, Patrick Midoux, Chantal Pichon, Jean-Marc Malinge
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
DNA minicircle
therapeutic oligonucleotide
decoy
transcription factor
STAT3
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122001640

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http://www.sciencedirect.com/science/article/pii/S2162253122001640

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