Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension
Background: Pregnancy induced hypertension (PIH) contributes greatly to maternal morbidity and mortality. Altered lipid profile and increased lipid peroxidation activate endothelial dysfunction and atherothrombosis leading to PIH. Therefore, estimation of lipid profile with serum malondialdehyde (MD...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-07-01
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| Series: | Journal of Clinical and Scientific Research |
| Subjects: | |
| Online Access: | http://svimstpt.ap.nic.in/jcsr/Jul-Sep15_files/3oa15.pdf |
| _version_ | 1828428426533404672 |
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| author | Saxena S Thimmaraju KV Srivastava PC Mallick AK Das B Sinha N Dalmia K |
| author_facet | Saxena S Thimmaraju KV Srivastava PC Mallick AK Das B Sinha N Dalmia K |
| author_sort | Saxena S |
| collection | DOAJ |
| description | Background: Pregnancy induced hypertension (PIH) contributes greatly to maternal morbidity and mortality. Altered lipid profile and increased lipid peroxidation activate endothelial dysfunction and atherothrombosis leading to PIH. Therefore, estimation of lipid profile with serum malondialdehyde (MDA) in pregnancy may be helpful in predicting the development of PIH and further progression.
Material and methods: In this prospective case-control study, serum lipid profile and MDA were estimated in 70 PIH subjects with gestational hypertension, pre-eclampsia, eclampsia; and 70 normotensive pregnant women aged 18 - 40 years, with gestational age of over 20 weeks.
Results: A statistically significant higher serum total cholesterol, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), TC/HDL-C, LDL-C/HDL-C and MDA, and a significantly lower HDL-C was noted in PIH subjects as compared to control subjects. When compared with the severity of PIH, all the lipoproteins (except HDL-C) along with MDA were found to be higher in women with eclampsia when compared with gestational hypertension, pre-eclampsia and normotensive pregnant women.
Conclusions: An abnormal lipid metabolism along with oxidative stress may add to the promotion of vascular dysfunction leading to PIH. Lipoproteins and MDA alter significantly in eclampsia. Therefore, during pregnancy, early diagnosis and management of dyslipidaemia may prevent lipid peroxidation and progression of PIH thereby preventing obstetric complications. |
| first_indexed | 2024-12-10T17:17:25Z |
| format | Article |
| id | doaj.art-25cfa41c6a4d4b1185043c82f5b57ba0 |
| institution | Directory Open Access Journal |
| issn | 2277-5706 2277-8357 |
| language | English |
| last_indexed | 2024-12-10T17:17:25Z |
| publishDate | 2015-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Scientific Research |
| spelling | doaj.art-25cfa41c6a4d4b1185043c82f5b57ba02022-12-22T01:40:05ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572015-07-0143205212http://dx.doi.org/10.15380/2277-5706.JCSR.14.059Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertensionSaxena S0Thimmaraju KV1Srivastava PC2Mallick AK3Das B4Sinha N5Dalmia K6Rohilkhand Medical College and Hospital, BareillyRohilkhand Medical College and Hospital, BareillyRohilkhand Medical College and Hospital, BareillyRohilkhand Medical College and Hospital, BareillyRohilkhand Medical College and Hospital, BareillyRohilkhand Medical College and Hospital, BareillyRohilkhand Medical College and Hospital, BareillyBackground: Pregnancy induced hypertension (PIH) contributes greatly to maternal morbidity and mortality. Altered lipid profile and increased lipid peroxidation activate endothelial dysfunction and atherothrombosis leading to PIH. Therefore, estimation of lipid profile with serum malondialdehyde (MDA) in pregnancy may be helpful in predicting the development of PIH and further progression. Material and methods: In this prospective case-control study, serum lipid profile and MDA were estimated in 70 PIH subjects with gestational hypertension, pre-eclampsia, eclampsia; and 70 normotensive pregnant women aged 18 - 40 years, with gestational age of over 20 weeks. Results: A statistically significant higher serum total cholesterol, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), TC/HDL-C, LDL-C/HDL-C and MDA, and a significantly lower HDL-C was noted in PIH subjects as compared to control subjects. When compared with the severity of PIH, all the lipoproteins (except HDL-C) along with MDA were found to be higher in women with eclampsia when compared with gestational hypertension, pre-eclampsia and normotensive pregnant women. Conclusions: An abnormal lipid metabolism along with oxidative stress may add to the promotion of vascular dysfunction leading to PIH. Lipoproteins and MDA alter significantly in eclampsia. Therefore, during pregnancy, early diagnosis and management of dyslipidaemia may prevent lipid peroxidation and progression of PIH thereby preventing obstetric complications.http://svimstpt.ap.nic.in/jcsr/Jul-Sep15_files/3oa15.pdfPregnancy Induced HypertensionEclampsiaDyslipidaemiaMalondialdehyde |
| spellingShingle | Saxena S Thimmaraju KV Srivastava PC Mallick AK Das B Sinha N Dalmia K Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension Journal of Clinical and Scientific Research Pregnancy Induced Hypertension Eclampsia Dyslipidaemia Malondialdehyde |
| title | Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension |
| title_full | Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension |
| title_fullStr | Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension |
| title_full_unstemmed | Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension |
| title_short | Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension |
| title_sort | role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension |
| topic | Pregnancy Induced Hypertension Eclampsia Dyslipidaemia Malondialdehyde |
| url | http://svimstpt.ap.nic.in/jcsr/Jul-Sep15_files/3oa15.pdf |
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