Reduced expression of phosphorylated ataxia-telangiectasia mutated gene is related to poor prognosis and gemcitabine chemoresistance in pancreatic cancer

Reduced expression of phosphorylated ataxia-telangiectasia mutated gene is related to poor prognosis and gemcitabine chemoresistance in pancreatic cancer

Abstract Background Loss of expression of the gene ataxia-telangiectasia mutated (ATM), occurring in patients with multiple primary malignancies, including pancreatic cancer, is associated with poor prognosis. In this study, we investigated the detailed molecular mechanism through which ATM expressi...

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Main Authors: Jingyu Xun, Hideo Ohtsuka, Katsuya Hirose, Daisuke Douchi, Shun Nakayama, Masaharu Ishida, Takayuki Miura, Kyohei Ariake, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Toru Furukawa, Michiaki Unno
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Cancer
Subjects:
Apoptosis
Ataxia telangiectasia
Drug therapy
Pancreatic neoplasms
Prognosis
Online Access:https://doi.org/10.1186/s12885-023-11294-3

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