Hyperbaric oxygen in children with cerebral palsy: A systematic review of effectiveness and safety.
<h4>Purpose</h4>To report current evidence regarding the effectiveness of hyperbaric oxygen therapy (HBOT) on the impairments presented by children with cerebral palsy (CP), and its safety.<h4>Materials and methods</h4>PUBMED, The Cochrane Library, Google Scholar, and the Und...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0276126 |
| _version_ | 1797990774798811136 |
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| author | Justine Laureau Christelle Pons Guy Letellier Raphaël Gross |
| author_facet | Justine Laureau Christelle Pons Guy Letellier Raphaël Gross |
| author_sort | Justine Laureau |
| collection | DOAJ |
| description | <h4>Purpose</h4>To report current evidence regarding the effectiveness of hyperbaric oxygen therapy (HBOT) on the impairments presented by children with cerebral palsy (CP), and its safety.<h4>Materials and methods</h4>PUBMED, The Cochrane Library, Google Scholar, and the Undersea and Hyperbaric Medical Society database were searched by two reviewers. Methodological quality was graded independently by 2 reviewers using the Physiotherapy Evidence Database assessment scale for randomized controlled trials (RCTs) and the modified Downs and Black (m-DB) evaluation tool for non RCTs. A meta-analysis was performed where applicable for RCTs.<h4>Results</h4>Five RCTs were identified. Four had a high level of evidence. Seven other studies were observational studies of low quality. All RCTs used 100% O2, 1.5 to 1.75 ATA, as the treatment intervention. Pressurized air was the control intervention in 3 RCTs, and physical therapy in 2. In all but one RCTs, similar improvements were observed regarding motor and/or cognitive functions, in the HBOT and control groups. Adverse events were mostly of mild severity, the most common being middle ear barotrauma (up to 50% of children).<h4>Conclusion</h4>There is high-level evidence that HBOT is ineffective in improving motor and cognitive functions, in children with CP. There is moderate-level evidence that HBOT is associated with a higher rate of adverse events than pressurized air in children. |
| first_indexed | 2024-04-11T08:41:45Z |
| format | Article |
| id | doaj.art-25d23c52bb2f406e8b3bc47a61fbde38 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T08:41:45Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-25d23c52bb2f406e8b3bc47a61fbde382022-12-22T04:34:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011710e027612610.1371/journal.pone.0276126Hyperbaric oxygen in children with cerebral palsy: A systematic review of effectiveness and safety.Justine LaureauChristelle PonsGuy LetellierRaphaël Gross<h4>Purpose</h4>To report current evidence regarding the effectiveness of hyperbaric oxygen therapy (HBOT) on the impairments presented by children with cerebral palsy (CP), and its safety.<h4>Materials and methods</h4>PUBMED, The Cochrane Library, Google Scholar, and the Undersea and Hyperbaric Medical Society database were searched by two reviewers. Methodological quality was graded independently by 2 reviewers using the Physiotherapy Evidence Database assessment scale for randomized controlled trials (RCTs) and the modified Downs and Black (m-DB) evaluation tool for non RCTs. A meta-analysis was performed where applicable for RCTs.<h4>Results</h4>Five RCTs were identified. Four had a high level of evidence. Seven other studies were observational studies of low quality. All RCTs used 100% O2, 1.5 to 1.75 ATA, as the treatment intervention. Pressurized air was the control intervention in 3 RCTs, and physical therapy in 2. In all but one RCTs, similar improvements were observed regarding motor and/or cognitive functions, in the HBOT and control groups. Adverse events were mostly of mild severity, the most common being middle ear barotrauma (up to 50% of children).<h4>Conclusion</h4>There is high-level evidence that HBOT is ineffective in improving motor and cognitive functions, in children with CP. There is moderate-level evidence that HBOT is associated with a higher rate of adverse events than pressurized air in children.https://doi.org/10.1371/journal.pone.0276126 |
| spellingShingle | Justine Laureau Christelle Pons Guy Letellier Raphaël Gross Hyperbaric oxygen in children with cerebral palsy: A systematic review of effectiveness and safety. PLoS ONE |
| title | Hyperbaric oxygen in children with cerebral palsy: A systematic review of effectiveness and safety. |
| title_full | Hyperbaric oxygen in children with cerebral palsy: A systematic review of effectiveness and safety. |
| title_fullStr | Hyperbaric oxygen in children with cerebral palsy: A systematic review of effectiveness and safety. |
| title_full_unstemmed | Hyperbaric oxygen in children with cerebral palsy: A systematic review of effectiveness and safety. |
| title_short | Hyperbaric oxygen in children with cerebral palsy: A systematic review of effectiveness and safety. |
| title_sort | hyperbaric oxygen in children with cerebral palsy a systematic review of effectiveness and safety |
| url | https://doi.org/10.1371/journal.pone.0276126 |
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