Conformational Changes Induced by S34Y and R98C Variants in the Death Domain of Myd88

Conformational Changes Induced by S34Y and R98C Variants in the Death Domain of Myd88

Myeloid differentiating factor 88 (Myd88) is a universal adaptor protein that plays a critical role in innate immunity by mediating TLR downstream signaling. Myd88 death domain (DD) forms an oligomeric complex by association with other DD-containing proteins such as IRAK4. Despite its universal role...

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Bibliographic Details
Main Authors: Vijayakumar Gosu, KyeongHye Won, Jae-Don Oh, Donghyun Shin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
Myd88
polymorphism
molecular dynamics simulation
principal components
betweenness centrality
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00027/full

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