The role of leukotrienes in the pathogenesis of systemic sclerosis
Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by widespread vascular injury and progressive fibrosis of the skin and internal organs. SSc-related involvement of the lungs, heart, kidneys and/or the gastrointestinal system accounts for the increased mortality of sclerod...
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| Format: | Article |
| Language: | English |
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Via Medica
2012-07-01
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| Series: | Folia Histochemica et Cytobiologica |
| Subjects: | |
| Online Access: | http://czasopisma.viamedica.pl/fhc/article/view/19348 |
| _version_ | 1819229954928279552 |
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| author | Sylwia Chwieśko-Minarowska Krzysztof Kowal Marek Bielecki Otylia Kowal-Bielecka |
| author_facet | Sylwia Chwieśko-Minarowska Krzysztof Kowal Marek Bielecki Otylia Kowal-Bielecka |
| author_sort | Sylwia Chwieśko-Minarowska |
| collection | DOAJ |
| description | Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by widespread vascular injury and progressive fibrosis of the skin and internal organs. SSc-related involvement of the lungs, heart, kidneys and/or the gastrointestinal system accounts for the increased mortality of scleroderma patients. Despite the progress which has recently been made in this field, the treatment of SSc is still unsatisfactory due to the low efficacy and/or high toxicity of available therapies. Leukotrienes are a family of lipid mediators synthesized from arachidonic acid in a process mediated by 5-lipoxygenase; they include leukotriene B4 and a group of cysteinyl leukotrienes: C4, D4, and E4. Leukotrienes play an important role in the regulation of all the processes vital to the pathogenesis of SSc, namely inflammation, vascular function and connective tissue remodeling. The available data suggests that an excessive synthesis of leukotrienes may contribute to the development and progression of SSc. Accordingly, blockade of leukotriene pathways appears to be a new, promising target for the reatment of SSc. |
| first_indexed | 2024-12-23T11:21:23Z |
| format | Article |
| id | doaj.art-25d4246b9c1d485c943f7137ab645891 |
| institution | Directory Open Access Journal |
| issn | 0239-8508 1897-5631 |
| language | English |
| last_indexed | 2024-12-23T11:21:23Z |
| publishDate | 2012-07-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Folia Histochemica et Cytobiologica |
| spelling | doaj.art-25d4246b9c1d485c943f7137ab6458912022-12-21T17:49:03ZengVia MedicaFolia Histochemica et Cytobiologica0239-85081897-56312012-07-0150210.5603/FHC.2012.0027The role of leukotrienes in the pathogenesis of systemic sclerosisSylwia Chwieśko-MinarowskaKrzysztof KowalMarek BieleckiOtylia Kowal-BieleckaSystemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by widespread vascular injury and progressive fibrosis of the skin and internal organs. SSc-related involvement of the lungs, heart, kidneys and/or the gastrointestinal system accounts for the increased mortality of scleroderma patients. Despite the progress which has recently been made in this field, the treatment of SSc is still unsatisfactory due to the low efficacy and/or high toxicity of available therapies. Leukotrienes are a family of lipid mediators synthesized from arachidonic acid in a process mediated by 5-lipoxygenase; they include leukotriene B4 and a group of cysteinyl leukotrienes: C4, D4, and E4. Leukotrienes play an important role in the regulation of all the processes vital to the pathogenesis of SSc, namely inflammation, vascular function and connective tissue remodeling. The available data suggests that an excessive synthesis of leukotrienes may contribute to the development and progression of SSc. Accordingly, blockade of leukotriene pathways appears to be a new, promising target for the reatment of SSc.http://czasopisma.viamedica.pl/fhc/article/view/19348leukotrienessclerodermaSSc-related insterstitial lung disease |
| spellingShingle | Sylwia Chwieśko-Minarowska Krzysztof Kowal Marek Bielecki Otylia Kowal-Bielecka The role of leukotrienes in the pathogenesis of systemic sclerosis Folia Histochemica et Cytobiologica leukotrienes scleroderma SSc-related insterstitial lung disease |
| title | The role of leukotrienes in the pathogenesis of systemic sclerosis |
| title_full | The role of leukotrienes in the pathogenesis of systemic sclerosis |
| title_fullStr | The role of leukotrienes in the pathogenesis of systemic sclerosis |
| title_full_unstemmed | The role of leukotrienes in the pathogenesis of systemic sclerosis |
| title_short | The role of leukotrienes in the pathogenesis of systemic sclerosis |
| title_sort | role of leukotrienes in the pathogenesis of systemic sclerosis |
| topic | leukotrienes scleroderma SSc-related insterstitial lung disease |
| url | http://czasopisma.viamedica.pl/fhc/article/view/19348 |
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