MRI Volumetric Analysis of the Thalamus and Hypothalamus in Amyotrophic Lateral Sclerosis
Background: Increasing evidence has shown that amyotrophic lateral sclerosis (ALS) can result in abnormal energy metabolism and sleep disorders, even before motor dysfunction. Although the hypothalamus and thalamus are important structures in these processes, few ALS studies have reported abnormal M...
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| Format: | Article |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.610332/full |
| _version_ | 1819173994771775488 |
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| author | Shan Ye Shan Ye Yishan Luo Yishan Luo Pingping Jin Pingping Jin Yajun Wang Yajun Wang Nan Zhang Nan Zhang Gan Zhang Gan Zhang Lu Chen Lu Chen Lin Shi Lin Shi Dongsheng Fan Dongsheng Fan |
| author_facet | Shan Ye Shan Ye Yishan Luo Yishan Luo Pingping Jin Pingping Jin Yajun Wang Yajun Wang Nan Zhang Nan Zhang Gan Zhang Gan Zhang Lu Chen Lu Chen Lin Shi Lin Shi Dongsheng Fan Dongsheng Fan |
| author_sort | Shan Ye |
| collection | DOAJ |
| description | Background: Increasing evidence has shown that amyotrophic lateral sclerosis (ALS) can result in abnormal energy metabolism and sleep disorders, even before motor dysfunction. Although the hypothalamus and thalamus are important structures in these processes, few ALS studies have reported abnormal MRI structural findings in the hypothalamus and thalamus.Purpose: We aimed to investigate volumetric changes in the thalamus and hypothalamus by using the automatic brain structure volumetry tool AccuBrain®.Methods: 3D T1-weighted magnetization-prepared gradient echo imaging (MPRAGE) scans were acquired from 16 patients with ALS with normal cognitive scores and 16 age-, sex- and education-matched healthy controls. Brain tissue and structure volumes were automatically calculated using AccuBrain®.Results: There were no significant differences in bilateral thalamic (F = 1.31, p = 0.287) or hypothalamic volumes (F = 1.65, p = 0.213) between the ALS and control groups by multivariate analysis of covariance (MANCOVA). Left and right hypothalamic volumes were correlated with whole-brain volume in patients with ALS (t = 3.19, p = 0.036; t = 3.03, p = 0.044), while the correlation between age and bilateral thalamic volumes tended to be significant after Bonferroni correction (t = 2.76, p = 0.068; t = 2.83, p = 0.06). In the control group, left and right thalamic volumes were correlated with whole-brain volume (t = 4.26, p = 0.004; t = 4.52, p = 0.004).Conclusion: Thalamic and hypothalamic volumes did not show differences between patients with normal frontotemporal function ALS and healthy controls, but further studies are still needed. |
| first_indexed | 2024-12-22T20:31:55Z |
| format | Article |
| id | doaj.art-25d439e2169948299dd0cbdf90fd05e5 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-22T20:31:55Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-25d439e2169948299dd0cbdf90fd05e52022-12-21T18:13:34ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-01-011310.3389/fnagi.2021.610332610332MRI Volumetric Analysis of the Thalamus and Hypothalamus in Amyotrophic Lateral SclerosisShan Ye0Shan Ye1Yishan Luo2Yishan Luo3Pingping Jin4Pingping Jin5Yajun Wang6Yajun Wang7Nan Zhang8Nan Zhang9Gan Zhang10Gan Zhang11Lu Chen12Lu Chen13Lin Shi14Lin Shi15Dongsheng Fan16Dongsheng Fan17Department of Neurology, Peking University Third Hospital, Beijing, ChinaBeijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, ChinaBrain Research Institute, Shenzhen, ChinaDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaBeijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaBeijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaBeijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaBeijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaBeijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, ChinaBrain Research Institute, Shenzhen, ChinaDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaDepartment of Neurology, Peking University Third Hospital, Beijing, ChinaBeijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, ChinaBackground: Increasing evidence has shown that amyotrophic lateral sclerosis (ALS) can result in abnormal energy metabolism and sleep disorders, even before motor dysfunction. Although the hypothalamus and thalamus are important structures in these processes, few ALS studies have reported abnormal MRI structural findings in the hypothalamus and thalamus.Purpose: We aimed to investigate volumetric changes in the thalamus and hypothalamus by using the automatic brain structure volumetry tool AccuBrain®.Methods: 3D T1-weighted magnetization-prepared gradient echo imaging (MPRAGE) scans were acquired from 16 patients with ALS with normal cognitive scores and 16 age-, sex- and education-matched healthy controls. Brain tissue and structure volumes were automatically calculated using AccuBrain®.Results: There were no significant differences in bilateral thalamic (F = 1.31, p = 0.287) or hypothalamic volumes (F = 1.65, p = 0.213) between the ALS and control groups by multivariate analysis of covariance (MANCOVA). Left and right hypothalamic volumes were correlated with whole-brain volume in patients with ALS (t = 3.19, p = 0.036; t = 3.03, p = 0.044), while the correlation between age and bilateral thalamic volumes tended to be significant after Bonferroni correction (t = 2.76, p = 0.068; t = 2.83, p = 0.06). In the control group, left and right thalamic volumes were correlated with whole-brain volume (t = 4.26, p = 0.004; t = 4.52, p = 0.004).Conclusion: Thalamic and hypothalamic volumes did not show differences between patients with normal frontotemporal function ALS and healthy controls, but further studies are still needed.https://www.frontiersin.org/articles/10.3389/fnagi.2021.610332/fullamyotrophic lateral sclerosisthalamushypothalamusvolumetric analysisMRI |
| spellingShingle | Shan Ye Shan Ye Yishan Luo Yishan Luo Pingping Jin Pingping Jin Yajun Wang Yajun Wang Nan Zhang Nan Zhang Gan Zhang Gan Zhang Lu Chen Lu Chen Lin Shi Lin Shi Dongsheng Fan Dongsheng Fan MRI Volumetric Analysis of the Thalamus and Hypothalamus in Amyotrophic Lateral Sclerosis Frontiers in Aging Neuroscience amyotrophic lateral sclerosis thalamus hypothalamus volumetric analysis MRI |
| title | MRI Volumetric Analysis of the Thalamus and Hypothalamus in Amyotrophic Lateral Sclerosis |
| title_full | MRI Volumetric Analysis of the Thalamus and Hypothalamus in Amyotrophic Lateral Sclerosis |
| title_fullStr | MRI Volumetric Analysis of the Thalamus and Hypothalamus in Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | MRI Volumetric Analysis of the Thalamus and Hypothalamus in Amyotrophic Lateral Sclerosis |
| title_short | MRI Volumetric Analysis of the Thalamus and Hypothalamus in Amyotrophic Lateral Sclerosis |
| title_sort | mri volumetric analysis of the thalamus and hypothalamus in amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis thalamus hypothalamus volumetric analysis MRI |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.610332/full |
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