The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas
Abstract The management of vestibular schwannoma (VS) with residual tumor following incomplete resection remains controversial and little is known regarding postoperative tumor volume changes. The behavior of residual tumors was analyzed for 111 patients who underwent surgery for newly diagnosed VS...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-84319-1 |
| _version_ | 1818721002194993152 |
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| author | Hun Ho Park So Hee Park Hyeong-Cheol Oh Hyun-Ho Jung Jong Hee Chang Kyu-Sung Lee Won Seok Chang Chang-Ki Hong |
| author_facet | Hun Ho Park So Hee Park Hyeong-Cheol Oh Hyun-Ho Jung Jong Hee Chang Kyu-Sung Lee Won Seok Chang Chang-Ki Hong |
| author_sort | Hun Ho Park |
| collection | DOAJ |
| description | Abstract The management of vestibular schwannoma (VS) with residual tumor following incomplete resection remains controversial and little is known regarding postoperative tumor volume changes. The behavior of residual tumors was analyzed for 111 patients who underwent surgery for newly diagnosed VS between September 2006 and July 2017. The postoperative tumor volume changes were assessed during a mean follow-up of 69 months (range 36–147 months). Fifty-three patients underwent imaging surveillance following incomplete resection. There was no residual tumor growth in 44 patients (83%). A significant regression of residual tumor volume was noted in the no growth group at postoperative 1 year (p = 0.028), 2 years (p = 0.012), but not from 3 years onwards. Significant predictors of regrowth were immediate postoperative tumor volume ≥ 0.7 cm3 (HR 10.5, p = 0.020) and residual tumor location other than the internal auditory canal (IAC) (HR 6.2, p = 0.026). The mean time to regrowth was 33 months (range 5–127 months). The 2-, 5-, and 10-year regrowth-free survival rates were 90.6%, 86.8%, and 83%, respectively. In conclusion, significant residual tumor regression could occur within 2 years for a VS with an immediate postoperative tumor volume less than 0.7 cm3 or residual tumor in IAC. |
| first_indexed | 2024-12-17T20:31:48Z |
| format | Article |
| id | doaj.art-25dbbc403cc74094bb3049d2f17f90c3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T20:31:48Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-25dbbc403cc74094bb3049d2f17f90c32022-12-21T21:33:34ZengNature PortfolioScientific Reports2045-23222021-02-0111111110.1038/s41598-021-84319-1The behavior of residual tumors following incomplete surgical resection for vestibular schwannomasHun Ho Park0So Hee Park1Hyeong-Cheol Oh2Hyun-Ho Jung3Jong Hee Chang4Kyu-Sung Lee5Won Seok Chang6Chang-Ki Hong7Department of Neurosurgery, Gangnam Severance Hospital, Yonsei University Health SystemDepartment of Neurosurgery, Severance Hospital, Yonsei University Health SystemDepartment of Neurosurgery, Gangnam Severance Hospital, Yonsei University Health SystemDepartment of Neurosurgery, Severance Hospital, Yonsei University Health SystemDepartment of Neurosurgery, Severance Hospital, Yonsei University Health SystemDepartment of Neurosurgery, Gangnam Severance Hospital, Yonsei University Health SystemDepartment of Neurosurgery, Severance Hospital, Yonsei University Health SystemDepartment of Neurosurgery, Gangnam Severance Hospital, Yonsei University Health SystemAbstract The management of vestibular schwannoma (VS) with residual tumor following incomplete resection remains controversial and little is known regarding postoperative tumor volume changes. The behavior of residual tumors was analyzed for 111 patients who underwent surgery for newly diagnosed VS between September 2006 and July 2017. The postoperative tumor volume changes were assessed during a mean follow-up of 69 months (range 36–147 months). Fifty-three patients underwent imaging surveillance following incomplete resection. There was no residual tumor growth in 44 patients (83%). A significant regression of residual tumor volume was noted in the no growth group at postoperative 1 year (p = 0.028), 2 years (p = 0.012), but not from 3 years onwards. Significant predictors of regrowth were immediate postoperative tumor volume ≥ 0.7 cm3 (HR 10.5, p = 0.020) and residual tumor location other than the internal auditory canal (IAC) (HR 6.2, p = 0.026). The mean time to regrowth was 33 months (range 5–127 months). The 2-, 5-, and 10-year regrowth-free survival rates were 90.6%, 86.8%, and 83%, respectively. In conclusion, significant residual tumor regression could occur within 2 years for a VS with an immediate postoperative tumor volume less than 0.7 cm3 or residual tumor in IAC.https://doi.org/10.1038/s41598-021-84319-1 |
| spellingShingle | Hun Ho Park So Hee Park Hyeong-Cheol Oh Hyun-Ho Jung Jong Hee Chang Kyu-Sung Lee Won Seok Chang Chang-Ki Hong The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas Scientific Reports |
| title | The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
| title_full | The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
| title_fullStr | The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
| title_full_unstemmed | The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
| title_short | The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
| title_sort | behavior of residual tumors following incomplete surgical resection for vestibular schwannomas |
| url | https://doi.org/10.1038/s41598-021-84319-1 |
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