No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
Abstract Experimental evidence suggests a crucial role of the autonomic nervous system in whole body metabolism with major regulatory effects of the parasympathetic branch in postprandial adaptation. However, the relative contribution of this mechanism is still not fully clear in humans. We therefor...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-11-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-77430-2 |
| _version_ | 1818346681923534848 |
|---|---|
| author | Andreas Vosseler Dongxing Zhao Louise Fritsche Rainer Lehmann Konstantinos Kantartzis Dana M. Small Andreas Peter Hans-Ulrich Häring Andreas L. Birkenfeld Andreas Fritsche Robert Wagner Hubert Preißl Stephanie Kullmann Martin Heni |
| author_facet | Andreas Vosseler Dongxing Zhao Louise Fritsche Rainer Lehmann Konstantinos Kantartzis Dana M. Small Andreas Peter Hans-Ulrich Häring Andreas L. Birkenfeld Andreas Fritsche Robert Wagner Hubert Preißl Stephanie Kullmann Martin Heni |
| author_sort | Andreas Vosseler |
| collection | DOAJ |
| description | Abstract Experimental evidence suggests a crucial role of the autonomic nervous system in whole body metabolism with major regulatory effects of the parasympathetic branch in postprandial adaptation. However, the relative contribution of this mechanism is still not fully clear in humans. We therefore compared the effects of transcutaneous auricular vagus nerve stimulation (taVNS, Cerbomed Nemos) with sham stimulation during an oral glucose tolerance test in a randomized, single-blind, cross-over design in 15 healthy lean men. Stimulation was performed for 150 min, 30 min before and during the entire oral glucose tolerance test with stimulation cycles of 30 s of on-phase and 30 s of off-phase and a 25 Hz impulse. Heart rate variability and plasma catecholamine levels were assessed as proxies of autonomic tone in the periphery. Neither analyzed heart rate variability parameters nor plasma catecholamine levels were significantly different between the two conditions. Plasma glucose, insulin sensitivity and insulin secretion were also comparable between conditions. Thus, the applied taVNS device or protocol was unable to achieve significant effects on autonomic innervation in peripheral organs. Accordingly, glucose metabolism remained unaltered. Therefore, alternative approaches are necessary to investigate the importance of the autonomic nervous system in postprandial human metabolism. |
| first_indexed | 2024-12-13T17:22:08Z |
| format | Article |
| id | doaj.art-25dc3cfb712440ad8931b977976f2e65 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T17:22:08Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-25dc3cfb712440ad8931b977976f2e652022-12-21T23:37:17ZengNature PortfolioScientific Reports2045-23222020-11-011011910.1038/s41598-020-77430-2No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy menAndreas Vosseler0Dongxing Zhao1Louise Fritsche2Rainer Lehmann3Konstantinos Kantartzis4Dana M. Small5Andreas Peter6Hans-Ulrich Häring7Andreas L. Birkenfeld8Andreas Fritsche9Robert Wagner10Hubert Preißl11Stephanie Kullmann12Martin Heni13Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, University Hospital TübingenInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of TübingenDepartment of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, University Hospital TübingenInstitute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital TübingenDepartment of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, University Hospital TübingenModern Diet and Physiology Research Center, Department of Psychiatry, Yale UniversityGerman Center for Diabetes Research (DZD e.V.)Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, University Hospital TübingenDepartment of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, University Hospital TübingenDepartment of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, University Hospital TübingenDepartment of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, University Hospital TübingenInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of TübingenInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of TübingenDepartment of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, University Hospital TübingenAbstract Experimental evidence suggests a crucial role of the autonomic nervous system in whole body metabolism with major regulatory effects of the parasympathetic branch in postprandial adaptation. However, the relative contribution of this mechanism is still not fully clear in humans. We therefore compared the effects of transcutaneous auricular vagus nerve stimulation (taVNS, Cerbomed Nemos) with sham stimulation during an oral glucose tolerance test in a randomized, single-blind, cross-over design in 15 healthy lean men. Stimulation was performed for 150 min, 30 min before and during the entire oral glucose tolerance test with stimulation cycles of 30 s of on-phase and 30 s of off-phase and a 25 Hz impulse. Heart rate variability and plasma catecholamine levels were assessed as proxies of autonomic tone in the periphery. Neither analyzed heart rate variability parameters nor plasma catecholamine levels were significantly different between the two conditions. Plasma glucose, insulin sensitivity and insulin secretion were also comparable between conditions. Thus, the applied taVNS device or protocol was unable to achieve significant effects on autonomic innervation in peripheral organs. Accordingly, glucose metabolism remained unaltered. Therefore, alternative approaches are necessary to investigate the importance of the autonomic nervous system in postprandial human metabolism.https://doi.org/10.1038/s41598-020-77430-2 |
| spellingShingle | Andreas Vosseler Dongxing Zhao Louise Fritsche Rainer Lehmann Konstantinos Kantartzis Dana M. Small Andreas Peter Hans-Ulrich Häring Andreas L. Birkenfeld Andreas Fritsche Robert Wagner Hubert Preißl Stephanie Kullmann Martin Heni No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men Scientific Reports |
| title | No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men |
| title_full | No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men |
| title_fullStr | No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men |
| title_full_unstemmed | No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men |
| title_short | No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men |
| title_sort | no modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation a cross over study in 15 healthy men |
| url | https://doi.org/10.1038/s41598-020-77430-2 |
| work_keys_str_mv | AT andreasvosseler nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT dongxingzhao nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT louisefritsche nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT rainerlehmann nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT konstantinoskantartzis nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT danamsmall nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT andreaspeter nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT hansulrichharing nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT andreaslbirkenfeld nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT andreasfritsche nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT robertwagner nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT hubertpreißl nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT stephaniekullmann nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen AT martinheni nomodulationofpostprandialmetabolismbytranscutaneousauricularvagusnervestimulationacrossoverstudyin15healthymen |