Glyceraldehyde-Derived Pyridinium Evokes Renal Tubular Cell Damage via RAGE Interaction

Glyceraldehyde-Derived Pyridinium Evokes Renal Tubular Cell Damage via RAGE Interaction

Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) contribute to proximal tubulopathy in diabetes. However, what glycer-AGE structure could evoke tubular cell damage remains unknown. We first examined if deleterious effects of glycer-AGEs on reactive oxygen species (ROS) generation...

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Bibliographic Details
Main Authors: Ami Sotokawauchi, Nobutaka Nakamura, Takanori Matsui, Yuichiro Higashimoto, Sho-ichi Yamagishi
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
GLAP
RAGE
diabetic nephropathy
proximal tubular cells
Online Access:https://www.mdpi.com/1422-0067/21/7/2604

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