A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases
<p>Abstract</p> <p>Giant cell tumor (GCT) of bone is a locally destructive tumor that occurs predominantly in long bones of post-pubertal adolescents and young adults, where it occurs in the epiphysis. The majority are treated by aggressive curettage or resection. Vascular invasion...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-09-01
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| Series: | Diagnostic Pathology |
| Online Access: | http://www.diagnosticpathology.org/content/5/1/62 |
| _version_ | 1818915466752557056 |
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| author | Gray Robert Mcnickle Allison Yin Suellen M Blank Alan Miller Ira J Gitelis Steven |
| author_facet | Gray Robert Mcnickle Allison Yin Suellen M Blank Alan Miller Ira J Gitelis Steven |
| author_sort | Gray Robert |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Giant cell tumor (GCT) of bone is a locally destructive tumor that occurs predominantly in long bones of post-pubertal adolescents and young adults, where it occurs in the epiphysis. The majority are treated by aggressive curettage or resection. Vascular invasion outside the boundary of the tumor can be seen. Metastasis, with identical morphology to the primary tumor, occurs in a few percent of cases, usually to the lung. On occasion GCTs of bone undergo frank malignant transformation to undifferentiated sarcomas. Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation. Concurrent metastases were found in the lung, but these were non-transformed GCT.</p> |
| first_indexed | 2024-12-20T00:02:44Z |
| format | Article |
| id | doaj.art-25deaf3582af4f1a9167cbafb688ea80 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-20T00:02:44Z |
| publishDate | 2010-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-25deaf3582af4f1a9167cbafb688ea802022-12-21T20:00:45ZengBMCDiagnostic Pathology1746-15962010-09-01516210.1186/1746-1596-5-62A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastasesGray RobertMcnickle AllisonYin Suellen MBlank AlanMiller Ira JGitelis Steven<p>Abstract</p> <p>Giant cell tumor (GCT) of bone is a locally destructive tumor that occurs predominantly in long bones of post-pubertal adolescents and young adults, where it occurs in the epiphysis. The majority are treated by aggressive curettage or resection. Vascular invasion outside the boundary of the tumor can be seen. Metastasis, with identical morphology to the primary tumor, occurs in a few percent of cases, usually to the lung. On occasion GCTs of bone undergo frank malignant transformation to undifferentiated sarcomas. Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation. Concurrent metastases were found in the lung, but these were non-transformed GCT.</p>http://www.diagnosticpathology.org/content/5/1/62 |
| spellingShingle | Gray Robert Mcnickle Allison Yin Suellen M Blank Alan Miller Ira J Gitelis Steven A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases Diagnostic Pathology |
| title | A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases |
| title_full | A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases |
| title_fullStr | A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases |
| title_full_unstemmed | A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases |
| title_short | A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases |
| title_sort | case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases |
| url | http://www.diagnosticpathology.org/content/5/1/62 |
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