A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique
The primary aim of the study was to prepare narrow sized polymeric nanoparticles by implementing few modifications to the conventional nanoprecipitation technique and to evaluate the effect of various process parameters on prepared polymeric nanoparticles. Eudragit E 100 nanoparticles were prepared...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2013-09-01
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| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v5i3.p107-115 |
| _version_ | 1827082689412333568 |
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| author | Moorthi Chidambaram Kathiresan Krishnasamy |
| author_facet | Moorthi Chidambaram Kathiresan Krishnasamy |
| author_sort | Moorthi Chidambaram |
| collection | DOAJ |
| description | The primary aim of the study was to prepare narrow sized polymeric nanoparticles by implementing few modifications to the conventional nanoprecipitation technique and to evaluate the effect of various process parameters on prepared polymeric nanoparticles. Eudragit E 100 nanoparticles were prepared by modified nanoprecipitation technique and step-by-step optimization was carried out to evaluate the effect of various process parameters such as organic solvent, polymer concentration, percentage of organic solvent, mode of addition of organic solvent in to aqueous phase, volume of aqueous phase, poloxamer 188 concentration, β-cyclodextrin concentration, temperature generated during sonication process, sonication duration, and drug concentration on the particle size, surface area, distribution width and uniformity of the prepared nanoparticles. The optimized process parameters were implemented to fabricate dual drug loaded Eudragit E 100 nanoparticles which were spherical in shape with mean particle size in the range of 118 to 140 nm, polydispersity index in the range of 0.187 to 0.254 and zeta potential in the range of 16.6 to 28.8 mV. Thus developed modified nanoprecipitation method can be used to fabricate narrow sized polymeric nanoparticles. |
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| format | Article |
| id | doaj.art-25dec655eaa440d78c0d4bcdc609443e |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2025-03-20T03:37:14Z |
| publishDate | 2013-09-01 |
| publisher | Tsinghua University Press |
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| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-25dec655eaa440d78c0d4bcdc609443e2024-10-03T06:23:55ZengTsinghua University PressNano Biomedicine and Engineering2150-55782013-09-015310711510.5101/nbe.v5i3.p107-115A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation TechniqueMoorthi Chidambaram0Kathiresan Krishnasamy1Department of Pharmacy, Annamalai University, Annamalai Nagar - 608 002, Chidambaram, Tamil Nadu, IndiaDepartment of Pharmacy, Annamalai University, Annamalai Nagar - 608 002, Chidambaram, Tamil Nadu, IndiaThe primary aim of the study was to prepare narrow sized polymeric nanoparticles by implementing few modifications to the conventional nanoprecipitation technique and to evaluate the effect of various process parameters on prepared polymeric nanoparticles. Eudragit E 100 nanoparticles were prepared by modified nanoprecipitation technique and step-by-step optimization was carried out to evaluate the effect of various process parameters such as organic solvent, polymer concentration, percentage of organic solvent, mode of addition of organic solvent in to aqueous phase, volume of aqueous phase, poloxamer 188 concentration, β-cyclodextrin concentration, temperature generated during sonication process, sonication duration, and drug concentration on the particle size, surface area, distribution width and uniformity of the prepared nanoparticles. The optimized process parameters were implemented to fabricate dual drug loaded Eudragit E 100 nanoparticles which were spherical in shape with mean particle size in the range of 118 to 140 nm, polydispersity index in the range of 0.187 to 0.254 and zeta potential in the range of 16.6 to 28.8 mV. Thus developed modified nanoprecipitation method can be used to fabricate narrow sized polymeric nanoparticles.https://www.sciopen.com/article/10.5101/nbe.v5i3.p107-115dual drug loaded polymeric nanoparticleseudragit e 100modified nanoprecipitation methodstep-by-step optimization |
| spellingShingle | Moorthi Chidambaram Kathiresan Krishnasamy A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique Nano Biomedicine and Engineering dual drug loaded polymeric nanoparticles eudragit e 100 modified nanoprecipitation method step-by-step optimization |
| title | A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique |
| title_full | A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique |
| title_fullStr | A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique |
| title_full_unstemmed | A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique |
| title_short | A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique |
| title_sort | step by step optimization process to fabricate narrow sized dual drug loaded polymeric nanoparticles using modified nanoprecipitation technique |
| topic | dual drug loaded polymeric nanoparticles eudragit e 100 modified nanoprecipitation method step-by-step optimization |
| url | https://www.sciopen.com/article/10.5101/nbe.v5i3.p107-115 |
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