ACVIM consensus statement guidelines on diagnosing and distinguishing low‐grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats
Abstract Background Lymphoplasmacytic enteritis (LPE) and low‐grade intestinal T cell lymphoma (LGITL) are common diseases in older cats, but their diagnosis and differentiation remain challenging. Objectives To summarize the current literature on etiopathogenesis and diagnosis of LPE and LGITL in c...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16690 |
| _version_ | 1827938005111799808 |
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| author | Sina Marsilio Valerie Freiche Eric Johnson Chiara Leo Anton W. Langerak Iain Peters Mark R. Ackermann |
| author_facet | Sina Marsilio Valerie Freiche Eric Johnson Chiara Leo Anton W. Langerak Iain Peters Mark R. Ackermann |
| author_sort | Sina Marsilio |
| collection | DOAJ |
| description | Abstract Background Lymphoplasmacytic enteritis (LPE) and low‐grade intestinal T cell lymphoma (LGITL) are common diseases in older cats, but their diagnosis and differentiation remain challenging. Objectives To summarize the current literature on etiopathogenesis and diagnosis of LPE and LGITL in cats and provide guidance on the differentiation between LPE and LGITL in cats. To provide statements established using evidence‐based approaches or where such evidence is lacking, statements based on consensus of experts in the field. Animals None. Methods A panel of 6 experts in the field (2 internists, 1 radiologist, 1 anatomic pathologist, 1 clonality expert, 1 oncologist) with the support of a human medical immunologist, was formed to assess and summarize evidence in the peer‐reviewed literature and complement it with consensus recommendations. Results Despite increasing interest on the topic for clinicians and pathologists, few prospective studies were available, and interpretation of the pertinent literature often was challenging because of the heterogeneity of the cases. Most recommendations by the panel were supported by a moderate or low level of evidence. Several understudied areas were identified, including cellular markers using immunohistochemistry, genomics, and transcriptomic studies. Conclusions and Clinical Importance To date, no single diagnostic criterion or known biomarker reliably differentiates inflammatory lesions from neoplastic lymphoproliferations in the intestinal tract of cats and a diagnosis currently is established by integrating all available clinical and diagnostic data. Histopathology remains the mainstay to better differentiate LPE from LGITL in cats with chronic enteropathy. |
| first_indexed | 2024-03-13T08:33:40Z |
| format | Article |
| id | doaj.art-25e03e6388534b95b5870b0f7a614cfa |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-03-13T08:33:40Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-25e03e6388534b95b5870b0f7a614cfa2023-05-31T01:33:58ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762023-05-0137379481610.1111/jvim.16690ACVIM consensus statement guidelines on diagnosing and distinguishing low‐grade neoplastic from inflammatory lymphocytic chronic enteropathies in catsSina Marsilio0Valerie Freiche1Eric Johnson2Chiara Leo3Anton W. Langerak4Iain Peters5Mark R. Ackermann6Department of Veterinary Medicine and Epidemiology UC Davis School of Veterinary Medicine Davis California USAEcole Nationale Vétérinaire d'Alfort CHUVA, Unité de Médecine Interne Maisons‐Alfort FranceDepartment of Surgical & Radiological Sciences UC Davis School of Veterinary Medicine Davis California USAAnicura Istituto Veterinario Novara Novara ItalyErasmus MC, University Medical Center Rotterdam The NetherlandsVeterinary Pathology Group (VPG) Exeter UKOregon Veterinary Diagnostic Laboratory, Oregon State University Corvallis Oregon USAAbstract Background Lymphoplasmacytic enteritis (LPE) and low‐grade intestinal T cell lymphoma (LGITL) are common diseases in older cats, but their diagnosis and differentiation remain challenging. Objectives To summarize the current literature on etiopathogenesis and diagnosis of LPE and LGITL in cats and provide guidance on the differentiation between LPE and LGITL in cats. To provide statements established using evidence‐based approaches or where such evidence is lacking, statements based on consensus of experts in the field. Animals None. Methods A panel of 6 experts in the field (2 internists, 1 radiologist, 1 anatomic pathologist, 1 clonality expert, 1 oncologist) with the support of a human medical immunologist, was formed to assess and summarize evidence in the peer‐reviewed literature and complement it with consensus recommendations. Results Despite increasing interest on the topic for clinicians and pathologists, few prospective studies were available, and interpretation of the pertinent literature often was challenging because of the heterogeneity of the cases. Most recommendations by the panel were supported by a moderate or low level of evidence. Several understudied areas were identified, including cellular markers using immunohistochemistry, genomics, and transcriptomic studies. Conclusions and Clinical Importance To date, no single diagnostic criterion or known biomarker reliably differentiates inflammatory lesions from neoplastic lymphoproliferations in the intestinal tract of cats and a diagnosis currently is established by integrating all available clinical and diagnostic data. Histopathology remains the mainstay to better differentiate LPE from LGITL in cats with chronic enteropathy.https://doi.org/10.1111/jvim.16690alimentarycatchronic diarrheaendoscopygastrointestinalhistology |
| spellingShingle | Sina Marsilio Valerie Freiche Eric Johnson Chiara Leo Anton W. Langerak Iain Peters Mark R. Ackermann ACVIM consensus statement guidelines on diagnosing and distinguishing low‐grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats Journal of Veterinary Internal Medicine alimentary cat chronic diarrhea endoscopy gastrointestinal histology |
| title | ACVIM consensus statement guidelines on diagnosing and distinguishing low‐grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats |
| title_full | ACVIM consensus statement guidelines on diagnosing and distinguishing low‐grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats |
| title_fullStr | ACVIM consensus statement guidelines on diagnosing and distinguishing low‐grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats |
| title_full_unstemmed | ACVIM consensus statement guidelines on diagnosing and distinguishing low‐grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats |
| title_short | ACVIM consensus statement guidelines on diagnosing and distinguishing low‐grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats |
| title_sort | acvim consensus statement guidelines on diagnosing and distinguishing low grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats |
| topic | alimentary cat chronic diarrhea endoscopy gastrointestinal histology |
| url | https://doi.org/10.1111/jvim.16690 |
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