Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release Systems
In this paper, the synthesis of new montmorillonite nanocomposite hydrogel (MMTNH) based on poly (acrylic acid-co-acrylamide) grafted onto starch, is described. Montmorillonite (MMT) as nanometer base, acrylic acid (AA) and acrylamide (AAm) as monomers, ammonium persulfate (APS) as an initiator, N,N...
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| Format: | Article |
| Language: | English |
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Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
2019-10-01
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| Series: | Iranian Journal of Chemistry & Chemical Engineering |
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| Online Access: | http://www.ijcce.ac.ir/article_32092_82568371c34ce7ce3bcf2f8a27cdd171.pdf |
| _version_ | 1818773443448930304 |
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| author | Shahrbanoo Zarei Ghasem Rezanejade Bardajee Mohamad Sadeghi |
| author_facet | Shahrbanoo Zarei Ghasem Rezanejade Bardajee Mohamad Sadeghi |
| author_sort | Shahrbanoo Zarei |
| collection | DOAJ |
| description | In this paper, the synthesis of new montmorillonite nanocomposite hydrogel (MMTNH) based on poly (acrylic acid-co-acrylamide) grafted onto starch, is described. Montmorillonite (MMT) as nanometer base, acrylic acid (AA) and acrylamide (AAm) as monomers, ammonium persulfate (APS) as an initiator, N,N-methylenebisacrylamide (MBA) as a crosslinker and starch as a biocompatible polymer were prepared in aqueous solution and their amounts were optimized to attain the highest water absorbance. The optimized swelling capacity in distilled water was found to be 810 g/g. A mechanism for hydrogel formation was proposed and the structure of the product was confirmed using a set of techniques including FT-IR spectroscopy, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, atomic force microscopy, and X-ray powder diffraction. Furthermore, the swelling behaviors of the nanocomposite at different pHs, various salt with different concentrations, the mixture of solvents, were investigated. The methylene blue (MB) dye was used as model drugs to assess the loading and release by MMTNH. The pH response of this MMTNH makes it suitable for acting as a controlled delivery system. The results suggest MMTNH may find applications as promising drug delivery vehicles for drug molecules. |
| first_indexed | 2024-12-18T10:25:20Z |
| format | Article |
| id | doaj.art-25e1f66752a2463d89bdfd16b2793c64 |
| institution | Directory Open Access Journal |
| issn | 1021-9986 1021-9986 |
| language | English |
| last_indexed | 2024-12-18T10:25:20Z |
| publishDate | 2019-10-01 |
| publisher | Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR |
| record_format | Article |
| series | Iranian Journal of Chemistry & Chemical Engineering |
| spelling | doaj.art-25e1f66752a2463d89bdfd16b2793c642022-12-21T21:10:59ZengIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRIranian Journal of Chemistry & Chemical Engineering1021-99861021-99862019-10-01385314332092Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release SystemsShahrbanoo Zarei0Ghasem Rezanejade Bardajee1Mohamad Sadeghi2Department of chemistry, Arak Branch, Islamic Azad University, Arak, I.R. IRANDepartment of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, I.R. IRANDepartment of chemistry, Arak Branch, Islamic Azad University, Arak, I.R. IRANIn this paper, the synthesis of new montmorillonite nanocomposite hydrogel (MMTNH) based on poly (acrylic acid-co-acrylamide) grafted onto starch, is described. Montmorillonite (MMT) as nanometer base, acrylic acid (AA) and acrylamide (AAm) as monomers, ammonium persulfate (APS) as an initiator, N,N-methylenebisacrylamide (MBA) as a crosslinker and starch as a biocompatible polymer were prepared in aqueous solution and their amounts were optimized to attain the highest water absorbance. The optimized swelling capacity in distilled water was found to be 810 g/g. A mechanism for hydrogel formation was proposed and the structure of the product was confirmed using a set of techniques including FT-IR spectroscopy, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, atomic force microscopy, and X-ray powder diffraction. Furthermore, the swelling behaviors of the nanocomposite at different pHs, various salt with different concentrations, the mixture of solvents, were investigated. The methylene blue (MB) dye was used as model drugs to assess the loading and release by MMTNH. The pH response of this MMTNH makes it suitable for acting as a controlled delivery system. The results suggest MMTNH may find applications as promising drug delivery vehicles for drug molecules.http://www.ijcce.ac.ir/article_32092_82568371c34ce7ce3bcf2f8a27cdd171.pdfnanocomposite hydrogelmontmorillonitestarchswelling behaviorrelease |
| spellingShingle | Shahrbanoo Zarei Ghasem Rezanejade Bardajee Mohamad Sadeghi Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release Systems Iranian Journal of Chemistry & Chemical Engineering nanocomposite hydrogel montmorillonite starch swelling behavior release |
| title | Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release Systems |
| title_full | Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release Systems |
| title_fullStr | Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release Systems |
| title_full_unstemmed | Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release Systems |
| title_short | Montmorillonite Nanocomposite Hydrogel Based on Poly(acrylicacid-co-acrylamide): Polymer Carrier for Controlled Release Systems |
| title_sort | montmorillonite nanocomposite hydrogel based on poly acrylicacid co acrylamide polymer carrier for controlled release systems |
| topic | nanocomposite hydrogel montmorillonite starch swelling behavior release |
| url | http://www.ijcce.ac.ir/article_32092_82568371c34ce7ce3bcf2f8a27cdd171.pdf |
| work_keys_str_mv | AT shahrbanoozarei montmorillonitenanocompositehydrogelbasedonpolyacrylicacidcoacrylamidepolymercarrierforcontrolledreleasesystems AT ghasemrezanejadebardajee montmorillonitenanocompositehydrogelbasedonpolyacrylicacidcoacrylamidepolymercarrierforcontrolledreleasesystems AT mohamadsadeghi montmorillonitenanocompositehydrogelbasedonpolyacrylicacidcoacrylamidepolymercarrierforcontrolledreleasesystems |