Characterization of Novel Dipeptidyl Peptidase-IV Inhibitory Peptides from Soft-Shelled Turtle Yolk Hydrolysate Using Orthogonal Bioassay-Guided Fractionations Coupled with In Vitro and In Silico Study

Characterization of Novel Dipeptidyl Peptidase-IV Inhibitory Peptides from Soft-Shelled Turtle Yolk Hydrolysate Using Orthogonal Bioassay-Guided Fractionations Coupled with In Vitro and In Silico Study

Five novel peptides (LPLF, WLQL, LPSW, VPGLAL, and LVGLPL) bearing dipeptidyl peptidase IV (DPP-IV) inhibitory activities were identified from the gastrointestinal enzymatic hydrolysate of soft-shelled turtle yolk (SSTY) proteins. Peptides were isolated separately using reversed-phase (RP) chromatog...

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Bibliographic Details
Main Authors: Nhung Thi Phuong Nong, Yu-Kuo Chen, Wen-Ling Shih, Jue-Liang Hsu
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceuticals
Subjects:
DPP-IV inhibitory peptides
soft-shelled turtle yolk protein
bioassay-guided fractionation
LC-MS/MS
in silico analysis
Online Access:https://www.mdpi.com/1424-8247/13/10/308

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https://www.mdpi.com/1424-8247/13/10/308

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