Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis

Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis

Abstract Background Pneumococcal meningitis is associated with high mortality and morbidity rates. Up to 50% of survivors show neurologic sequelae including hearing loss, cognitive impairments and learning disabilities, being particularly detrimental in affected infants and children where adjuvant t...

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Bibliographic Details
Main Authors: Lukas Muri, Denis Grandgirard, Michelle Buri, Michael Perny, Stephen L. Leib
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Pneumococcal meningitis
Brain injury
Neurologic sequelae
Neuroinflammation
Hearing loss
Combined adjuvant therapy
Online Access:http://link.springer.com/article/10.1186/s12974-018-1272-8

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