Associations of novel serum lipid index with epithelial ovarian cancer chemoresistance and prognosis
PurposeTo evaluate the relationship between novel serum lipid index and chemoresistance as well as prognosis of epithelial ovarian cancer (EOC).Patients and methodsPatients’ serum lipid profiles of 249 cases diagnosed with epithelial ovarian cancer, including total cholesterol (TC), high-density lip...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1052760/full |
| _version_ | 1811165317244649472 |
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| author | Yuan Li Chunliang Shang Huamao Liang Kun Zhang Yu Wu Hongyan Guo |
| author_facet | Yuan Li Chunliang Shang Huamao Liang Kun Zhang Yu Wu Hongyan Guo |
| author_sort | Yuan Li |
| collection | DOAJ |
| description | PurposeTo evaluate the relationship between novel serum lipid index and chemoresistance as well as prognosis of epithelial ovarian cancer (EOC).Patients and methodsPatients’ serum lipid profiles of 249 cases diagnosed with epithelial ovarian cancer, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) as well as their ratios, the novel indicators HDL-C/TC and HDL-C/LDL-C, and clinicopathologic characteristics were retrospectively collected and calculated from January 2016 to January 2020 and correlation between serum lipid index and clinicopathological features such as chemoresistance as well as prognosis were evaluated.Results249 patients pathologically diagnosed EOC who underwent cytoreductive surgery were included in our cohort. The mean age of these patients was 55.20 ± 11.07 years. Binary logistic regression analyses indicated Federation International of Gynecology and Obstetrics (FIGO(stage and HDL-C/TC ratio had significant association with chemoresistance. Univariate analyses demonstrated pathological type, chemoresistance, FIGO stage, neoadjuvant chemotherapy, maintenance treatment, HDL-C/LDL-C ratio, HDL-C/TC ratio were related to Progression-Free Survival (PFS) and Overall Survival (OS) (P<0. 05). Particularly, multivariate analyses indicated that HDL-C/LDL-C ratio was independent protective factors for both PFS and OS.ConclusionThe complex serum lipid index HDL-C/TC ratio has a significant correlation with chemoresistance. HDL-C/LDL-C ratio is closely related to the clinicopathological characteristics and prognosis of patients with EOC and is an independent protective factor indicating better outcome. |
| first_indexed | 2024-04-10T15:35:18Z |
| format | Article |
| id | doaj.art-25e5f1c592c444569ff627bb54980a1b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T15:35:18Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-25e5f1c592c444569ff627bb54980a1b2023-02-13T05:41:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.10527601052760Associations of novel serum lipid index with epithelial ovarian cancer chemoresistance and prognosisYuan LiChunliang ShangHuamao LiangKun ZhangYu WuHongyan GuoPurposeTo evaluate the relationship between novel serum lipid index and chemoresistance as well as prognosis of epithelial ovarian cancer (EOC).Patients and methodsPatients’ serum lipid profiles of 249 cases diagnosed with epithelial ovarian cancer, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) as well as their ratios, the novel indicators HDL-C/TC and HDL-C/LDL-C, and clinicopathologic characteristics were retrospectively collected and calculated from January 2016 to January 2020 and correlation between serum lipid index and clinicopathological features such as chemoresistance as well as prognosis were evaluated.Results249 patients pathologically diagnosed EOC who underwent cytoreductive surgery were included in our cohort. The mean age of these patients was 55.20 ± 11.07 years. Binary logistic regression analyses indicated Federation International of Gynecology and Obstetrics (FIGO(stage and HDL-C/TC ratio had significant association with chemoresistance. Univariate analyses demonstrated pathological type, chemoresistance, FIGO stage, neoadjuvant chemotherapy, maintenance treatment, HDL-C/LDL-C ratio, HDL-C/TC ratio were related to Progression-Free Survival (PFS) and Overall Survival (OS) (P<0. 05). Particularly, multivariate analyses indicated that HDL-C/LDL-C ratio was independent protective factors for both PFS and OS.ConclusionThe complex serum lipid index HDL-C/TC ratio has a significant correlation with chemoresistance. HDL-C/LDL-C ratio is closely related to the clinicopathological characteristics and prognosis of patients with EOC and is an independent protective factor indicating better outcome.https://www.frontiersin.org/articles/10.3389/fonc.2023.1052760/fullserum lipidsepithelial ovarian cancerchemoresistanceprognosisnovel serum lipid index |
| spellingShingle | Yuan Li Chunliang Shang Huamao Liang Kun Zhang Yu Wu Hongyan Guo Associations of novel serum lipid index with epithelial ovarian cancer chemoresistance and prognosis Frontiers in Oncology serum lipids epithelial ovarian cancer chemoresistance prognosis novel serum lipid index |
| title | Associations of novel serum lipid index with epithelial ovarian cancer chemoresistance and prognosis |
| title_full | Associations of novel serum lipid index with epithelial ovarian cancer chemoresistance and prognosis |
| title_fullStr | Associations of novel serum lipid index with epithelial ovarian cancer chemoresistance and prognosis |
| title_full_unstemmed | Associations of novel serum lipid index with epithelial ovarian cancer chemoresistance and prognosis |
| title_short | Associations of novel serum lipid index with epithelial ovarian cancer chemoresistance and prognosis |
| title_sort | associations of novel serum lipid index with epithelial ovarian cancer chemoresistance and prognosis |
| topic | serum lipids epithelial ovarian cancer chemoresistance prognosis novel serum lipid index |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1052760/full |
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