Validation of an Italian Questionnaire of Adherence to the Ketogenic Dietary Therapies: iKetoCheck
Ketogenic dietary therapies (KDTs) are an effective and safe non-pharmacological treatment for drug-resistant epilepsy, but adherence can be challenging for both patients and caregivers. In Europe, there are no adequate tools to measure it other than monitoring ketosis. This study aimed to adapt and...
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MDPI AG
2023-08-01
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| Online Access: | https://www.mdpi.com/2304-8158/12/17/3214 |
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| author | Lenycia de Cassya Lopes Neri Monica Guglielmetti Valentina De Giorgis Ludovica Pasca Martina Paola Zanaboni Claudia Trentani Elena Ballante Serena Grumi Cinzia Ferraris Anna Tagliabue on behalf of the KDTs Delphi Validation Study Group |
| author_facet | Lenycia de Cassya Lopes Neri Monica Guglielmetti Valentina De Giorgis Ludovica Pasca Martina Paola Zanaboni Claudia Trentani Elena Ballante Serena Grumi Cinzia Ferraris Anna Tagliabue on behalf of the KDTs Delphi Validation Study Group |
| author_sort | Lenycia de Cassya Lopes Neri |
| collection | DOAJ |
| description | Ketogenic dietary therapies (KDTs) are an effective and safe non-pharmacological treatment for drug-resistant epilepsy, but adherence can be challenging for both patients and caregivers. In Europe, there are no adequate tools to measure it other than monitoring ketosis. This study aimed to adapt and validate the Brazilian adherence questionnaire, Keto-check, into the Italian version: iKetoCheck. Using the Delphi technique, 12 judges validated the contents through agreement rates and the Content Validity Index (CVI). The iKetocheck was self-completed electronically by 61 drug-resistant epilepsy or GLUT1 deficiency patients within an interval of 15 days to measure its reproducibility. The test–retest reliability was evaluated using Pearson’s correlation and relative significance test. Exploratory and confirmatory factorial analyses were made using Factor software version 12.03.02. The final tool, iKetoCheck, consists of 10 questions with 5-point Likert scale answers. It evaluates various aspects such as informing caregivers about the diet, organization of meals, measurement of ketosis, weighing food consumed, diet negligence, use of carbohydrate-free medications, attending follow-up visits, reading food labels, consulting an expert for dietary concerns, and cooking at home. The factorial analysis resulted in three factors: “attention,” “organization,” and “precision,” with satisfactory results for indices in exploratory and confirmatory analyses. Although higher mean values of ketonemia measurement were observed in patients with a higher adherence score, these values were not statistically significant (<i>p</i> = 0.284). In conclusion, despite the small sample size, iKetoCheck is a valid tool for evaluating KDTs’ adherence in Italian drug-resistant epilepsy or GLUT1 deficiency patients. It can provide valuable information to improve patient management and optimize the effectiveness of KDTs. |
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| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T23:23:17Z |
| publishDate | 2023-08-01 |
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| spelling | doaj.art-25e6c72df69b423d89aaf954dbfba3f62023-11-19T08:08:27ZengMDPI AGFoods2304-81582023-08-011217321410.3390/foods12173214Validation of an Italian Questionnaire of Adherence to the Ketogenic Dietary Therapies: iKetoCheckLenycia de Cassya Lopes Neri0Monica Guglielmetti1Valentina De Giorgis2Ludovica Pasca3Martina Paola Zanaboni4Claudia Trentani5Elena Ballante6Serena Grumi7Cinzia Ferraris8Anna Tagliabue9on behalf of the KDTs Delphi Validation Study GroupFaculty of Medicine, Department of Pediatrics, University of São Paulo, São Paulo 05403-000, BrazilKetogenic Metabolic Therapy Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, ItalyChild Neurology and Psychiatry Unit, IRCCS Mondino Foundation, 27100 Pavia, ItalyChild Neurology and Psychiatry Unit, IRCCS Mondino Foundation, 27100 Pavia, ItalyChild Neurology and Psychiatry Unit, IRCCS Mondino Foundation, 27100 Pavia, ItalyKetogenic Metabolic Therapy Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, ItalyBioData Science Unit, Department of Political and Social Sciences, University of Pavia, Mondino Foundation, 27100 Pavia, ItalyLaboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, ItalyKetogenic Metabolic Therapy Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, ItalyKetogenic Metabolic Therapy Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, ItalyKetogenic dietary therapies (KDTs) are an effective and safe non-pharmacological treatment for drug-resistant epilepsy, but adherence can be challenging for both patients and caregivers. In Europe, there are no adequate tools to measure it other than monitoring ketosis. This study aimed to adapt and validate the Brazilian adherence questionnaire, Keto-check, into the Italian version: iKetoCheck. Using the Delphi technique, 12 judges validated the contents through agreement rates and the Content Validity Index (CVI). The iKetocheck was self-completed electronically by 61 drug-resistant epilepsy or GLUT1 deficiency patients within an interval of 15 days to measure its reproducibility. The test–retest reliability was evaluated using Pearson’s correlation and relative significance test. Exploratory and confirmatory factorial analyses were made using Factor software version 12.03.02. The final tool, iKetoCheck, consists of 10 questions with 5-point Likert scale answers. It evaluates various aspects such as informing caregivers about the diet, organization of meals, measurement of ketosis, weighing food consumed, diet negligence, use of carbohydrate-free medications, attending follow-up visits, reading food labels, consulting an expert for dietary concerns, and cooking at home. The factorial analysis resulted in three factors: “attention,” “organization,” and “precision,” with satisfactory results for indices in exploratory and confirmatory analyses. Although higher mean values of ketonemia measurement were observed in patients with a higher adherence score, these values were not statistically significant (<i>p</i> = 0.284). In conclusion, despite the small sample size, iKetoCheck is a valid tool for evaluating KDTs’ adherence in Italian drug-resistant epilepsy or GLUT1 deficiency patients. It can provide valuable information to improve patient management and optimize the effectiveness of KDTs.https://www.mdpi.com/2304-8158/12/17/3214adherencepatient complianceketogenic dietepilepsyGLUT1 deficiencytreatment adherence and compliance |
| spellingShingle | Lenycia de Cassya Lopes Neri Monica Guglielmetti Valentina De Giorgis Ludovica Pasca Martina Paola Zanaboni Claudia Trentani Elena Ballante Serena Grumi Cinzia Ferraris Anna Tagliabue on behalf of the KDTs Delphi Validation Study Group Validation of an Italian Questionnaire of Adherence to the Ketogenic Dietary Therapies: iKetoCheck Foods adherence patient compliance ketogenic diet epilepsy GLUT1 deficiency treatment adherence and compliance |
| title | Validation of an Italian Questionnaire of Adherence to the Ketogenic Dietary Therapies: iKetoCheck |
| title_full | Validation of an Italian Questionnaire of Adherence to the Ketogenic Dietary Therapies: iKetoCheck |
| title_fullStr | Validation of an Italian Questionnaire of Adherence to the Ketogenic Dietary Therapies: iKetoCheck |
| title_full_unstemmed | Validation of an Italian Questionnaire of Adherence to the Ketogenic Dietary Therapies: iKetoCheck |
| title_short | Validation of an Italian Questionnaire of Adherence to the Ketogenic Dietary Therapies: iKetoCheck |
| title_sort | validation of an italian questionnaire of adherence to the ketogenic dietary therapies iketocheck |
| topic | adherence patient compliance ketogenic diet epilepsy GLUT1 deficiency treatment adherence and compliance |
| url | https://www.mdpi.com/2304-8158/12/17/3214 |
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