Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma
N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as transla...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268121002374 |
| _version_ | 1830284202745004032 |
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| author | Yue-fan Wang Chun-mei Ge Hao-zan Yin Zhi-hui Dai Jun-peng Dong Man Ji Fu Yang |
| author_facet | Yue-fan Wang Chun-mei Ge Hao-zan Yin Zhi-hui Dai Jun-peng Dong Man Ji Fu Yang |
| author_sort | Yue-fan Wang |
| collection | DOAJ |
| description | N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as translation, splicing, export and degradation. These processes are catalyzed by three types of prominent enzymes: writers, erasers and readers. Increasing evidence has shown that m6A modification is vital for the regulation of gene expression, carcinogenesis, tumor progression and other abnormal changes, and recent studies have shown that m6A is important in the development of hepatocellular carcinoma (HCC). Herein, we summarize the nature and regulatory mechanisms of m6A modification, including its role in the pathogenesis of HCC and related chronic liver diseases. We also highlight the clinical significance and future strategies involving RNA m6A modifications in HCC. |
| first_indexed | 2024-12-19T03:15:25Z |
| format | Article |
| id | doaj.art-25e7777aa4be42af887a7cf0640d47c8 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-19T03:15:25Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-25e7777aa4be42af887a7cf0640d47c82022-12-21T20:37:54ZengElsevierAnnals of Hepatology1665-26812021-11-0125100538Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinomaYue-fan Wang0Chun-mei Ge1Hao-zan Yin2Zhi-hui Dai3Jun-peng Dong4Man Ji5Fu Yang6The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.Corresponding author at: The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.; The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as translation, splicing, export and degradation. These processes are catalyzed by three types of prominent enzymes: writers, erasers and readers. Increasing evidence has shown that m6A modification is vital for the regulation of gene expression, carcinogenesis, tumor progression and other abnormal changes, and recent studies have shown that m6A is important in the development of hepatocellular carcinoma (HCC). Herein, we summarize the nature and regulatory mechanisms of m6A modification, including its role in the pathogenesis of HCC and related chronic liver diseases. We also highlight the clinical significance and future strategies involving RNA m6A modifications in HCC.http://www.sciencedirect.com/science/article/pii/S1665268121002374N6-methyladenosineRNA m6A modificationChronic liver diseasesHCC |
| spellingShingle | Yue-fan Wang Chun-mei Ge Hao-zan Yin Zhi-hui Dai Jun-peng Dong Man Ji Fu Yang Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma Annals of Hepatology N6-methyladenosine RNA m6A modification Chronic liver diseases HCC |
| title | Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma |
| title_full | Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma |
| title_fullStr | Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma |
| title_full_unstemmed | Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma |
| title_short | Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma |
| title_sort | dysregulated n6 methyladenosine m6a processing in hepatocellular carcinoma |
| topic | N6-methyladenosine RNA m6A modification Chronic liver diseases HCC |
| url | http://www.sciencedirect.com/science/article/pii/S1665268121002374 |
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